Mendelian randomization analysis

Results 131 to 140 of about 23,652,556 (316)

Mendelian randomization analysis of MASLD-related diseases and cognitive performance.

Mendelian randomization analysis of MASLD-related diseases and cognitive performance.
Jing-Na Lin (2634634) +7 more
core +1 more source

Shared and Distinguishing Features of Late‐Onset Rheumatic Diseases Fulfilling Polymyalgia Rheumatica Classification Criteria

Arthritis &Rheumatology, EarlyView.
Kerem Abacar +5 more
wiley +1 more source

Chronic Prostatitis/Chronic Pelvic Pain Syndrome: Research Progress and Precision Diagnosis‐Therapy Under the Integrated Neuro–Immune–Metabolic–Microbiota Axis Framework

iMetaMed, EarlyView.
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is increasingly recognized as a systemic disorder rather than a purely local prostate disease. The diagram illustrates the transition from the traditional local prostate‐centered model to a multi‐axis systemic framework involving clinical heterogeneity, local prostatic inflammation, systemic ...
Kun Wang +10 more
wiley +1 more source

Gut microbiota, blood metabolites, & pan-cancer: a bidirectional Mendelian randomization & mediation analysis

AMB Express
We propose using Mendelian randomization analysis on GWAS data and MetaboAnalyst to model gut microbiota, metabolic pathways, blood metabolites, and cancer risk. We examined 473 gut microbiota, 205 pathways, 1400 metabolites, and 8 cancers.
Biqing Luan +8 more
doaj +1 more source

Overview of the data used in the mendelian randomization analysis.

Overview of the data used in the mendelian randomization analysis.
Jing-Na Lin (2634634) +7 more
core +1 more source

Artificial intelligence‐driven bioinformatics: From analytical pipelines to model‐centered biological discovery

iMetaOmics, EarlyView.
AI‐driven bioinformatics is best viewed as an emerging model‐centered discovery framework in which learned representations increasingly support prediction, intervention design, and workflow orchestration, while classical pipelines remain essential for validation and reproducibility.
Songming Chen +10 more
wiley +1 more source

Mendelian randomization analysis of MASLD-related diseases and any dementia.

Mendelian randomization analysis of MASLD-related diseases and any dementia.
Jing-Na Lin (2634634) +7 more
core +1 more source

Identifying atheroprotective fruits and vegetables by Mendelian Randomization analysis

Frontiers in Nutrition
BackgroundFruits and vegetables (FVs) are widely believed to mitigate the risk of atherosclerosis (AS). However, the causal relationships between specific FVs and AS risk factors remain unclear.MethodsThis study performed two-sample Mendelian Randomization (MR) analysis to infer the causality of the intake of 28 kinds of FVs with AS, as well as its ...
Shenji Yang +5 more
openaire +3 more sources

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang +5 more
wiley +1 more source

Hypothyroidism correlates with osteoporosis: potential involvement of lipid mediators

Frontiers in Medicine
BackgroundObservational studies have demonstrated a correlation between thyroid dysfunction and osteoporosis (OP); however, the underlying causality has yet to be fully elucidated.MethodsThe necessary dataset was sourced from public databases. Initially,
Pengyuan Leng +7 more
doaj +1 more source

mendelian randomization
medicine general
gut microbiota

causal inference
causal relationship