Results 151 to 160 of about 23,652,556 (316)

Mendelian Randomization Analysis Supports a Causal Relationship Between Circulating Inflammatory Proteins and Basal Cell Carcinoma [PDF]

Zhi-da Fu,1,2,* Yao Wang,3,* Hong-li Yan,2 Jian-hua Wu1 1Department of Dermatology, Changhai Hospital, Naval Medical University, Shanghai, People’s Republic of China; 2Center for Reproductive Medicine, Changhai Hospital, Naval Medical University,
Yan HL, Fu ZD, Wang Y, Wu JH
core  

DHEA and response to antidepressant treatment: A Mendelian Randomization analysis

Journal of Psychiatric Research
Treatment response is hard to predict and detailed mechanisms unknown. Lower levels of the dehydroepiandrosterone sulphate (DHEA(S)) - a precursor to testosterone and estrogen - have been associated to depression and to response to antidepressant treatment. Previous studies however may have been ridden by confounding and reverse causation.
Souza-Teodoro, LH, Davies, NM, Warren, HR, Andrade, LHSG, Carvalho, LA   +4 more
openaire   +4 more sources

Identification and quality characterization of a putative novel 17x + 8y high‐molecular‐weight glutenin subunit recombination in bread wheat

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND High‐molecular‐weight glutenin subunits (HMW‐GSs) are major determinants of dough rheological behavior and bread‐making quality in bread wheat (Triticum aestivum L.). Among wheat genomes, the Glu‐B1 locus exhibits the highest allelic diversity; however, recombination events between x‐ and y‐type HMW‐GS genes are considered extremely
Nevzat Aydin, Bedrettin Demir, Mehmet Koyuncu, Jan Bocianowski, Aras Türkoğlu   +4 more
wiley   +1 more source

Examining the multivariate genetic architectures of posttraumatic stress disorder and cardiovascular disease phenotypes

Journal of Traumatic Stress, EarlyView.
Abstract Posttraumatic stress disorder (PTSD) is associated with elevated cardiovascular disease (CVD) risk, but the extent of shared inherited liability is unclear. Large genome‐wide association studies (GWAS) allow for multivariate evaluation of common genetic architecture.
Shannon E. Cusack, Nina Adler, Peter B. Barr, Xiang Zhao, Antonia V. Seligowski, Sage E. Hawn, Erika J. Wolf, PGC‐PTSD Physical Health Workgroup, Jennifer A. Sumner, Ananda B. Amstadter   +9 more
wiley   +1 more source

Evaluation of the Association Between Postpartum Hemorrhage and Antidepressant Use: A Mendelian Randomization Study

Drugs - Real World Outcomes
Background The relationship between antidepressants, depression, and the incidence of postpartum hemorrhage (PPH) has been reported in observational studies, but the causal link between these factors remains unknown.
Zhenzhen Chen, Qingqing Lv, Shiteng Lin, Wanlong Lin, Wei Zhuang   +4 more
doaj   +1 more source

Estimated Body Fat Percentage and Triglyceride‐Glucose Index for Identifying MASLD in Lean Asian Adults: A Cross‐Sectional Analysis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) is increasingly prevalent among lean Asian populations, yet effective strategies for identifying high‐risk individuals remain limited. We investigated the associations of body fat percentage (BF%) and the triglyceride‐glucose (TyG) index with lean MASLD and evaluated their ...
Xiang‐Ran Kong, Ya‐Li Chen, Rui Li, Lu‐Xiang Shang, Sha Sha   +4 more
wiley   +1 more source

Gut microbiota influences colorectal cancer through immune cell interactions: a Mendelian randomization study

Discover Oncology
Background Colorectal cancer (CRC) is the most prevalent malignant tumor of the digestive system globally, posing a significant threat to human health and quality of life.
Linyi Zheng, Yuqiang Li, Cenap Güngör, Heming Ge   +3 more
doaj   +1 more source

Association between Lp(a) and T2D: a Mendelian randomization study

Introduction Blood lipoprotein(a) (Lp(a)) levels have been observed to be inversely correlated with type 2 diabetes (T2D). In this Mendelian randomization (MR) study, the causal impact of genetically predicted Lp(a) on T2D was assessed.
Tadeusz Osadnik, Mateusz Lejawa, Jacek Jóźwiak, Marek Gierlotka, Marcin Goławski, Maciej Banach   +5 more
core   +1 more source

Disulfidptosis‐ and Ferroptosis‐Related Gene Signatures in Rheumatoid Arthritis: Association Analysis and Diagnostic Model Construction

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and progressive joint damage. Although ferroptosis has been implicated in RA progression, the role of disulfidptosis and its interaction with ferroptosis remains unclear.
Ting‐Ting Wang, Dong‐Mei Wang, Xue Li, Yuan‐Li Wei, Ping‐Dan Liu, Shi‐Lin Li, Si‐Ying Xiong, Cai‐Zhen Liu, Fan‐Xin Zeng, Jian‐Hong Wu, Lin Tang   +10 more
wiley   +1 more source

Juvenile idiopathic arthritis and primary ovarian failure: a two-sample Mendelian randomization analysis in a mixed-gender cohort

Frontiers in Endocrinology
BackgroundThe causal relationship between juvenile idiopathic arthritis (JIA) and primary ovarian failure (POF) remains uncertain. To elucidate this relationship, we employed a two-sample Mendelian randomization analysis.MethodsThe single nucleotide ...
Yuanhang Mo, Anquan Shang, Guoguo Wei, Donghui Xu, Yuxi Hou, Xiaowen Shao, Chaoyan Yue   +6 more
doaj   +1 more source