Results 171 to 180 of about 42,228 (267)

Causal associations between ankylosing spondylitis and cardiovascular disease: a mendelian randomization analysis. [PDF]

Clinics (Sao Paulo)
Zhou L, Tang Y, Jiang J.
europepmc   +1 more source

Single‐Cell Transcriptomics and Mendelian Randomization Analysis Reveal Key Genes in Atrial Fibrillation

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Background Atrial fibrillation (AF) is one of the most common cardiac arrhythmias. It reduces quality of life and increases the risk of complications such as stroke. Although progress has been made in understanding its pathogenesis, the key cellular subtypes and therapeutic targets remain unclear. Methods We applied single‐cell transcriptomics
Xiangpeng Chen, Hongquan Chen, Shiguang Xu, Shumin Wang, Huishan Wang, Hao Meng   +5 more
wiley   +1 more source

Student–teacher relationships as a mediator of children's education‐linked genetics: results from the Norwegian Mother, Father and Child Cohort Study

Journal of Child Psychology and Psychiatry, EarlyView.
Background Genetic differences are robustly associated with educational outcomes, but how they become linked is poorly understood. A plausible hypothesis, yet to be thoroughly empirically tested, is that the school environment mediates the association. Methods Using structural equation models, we tested whether the student–teacher relationship at age 5
Chloe Austerberry, Elizabeth C. Corfield, Alexandra Havdahl, Dinka Smajlagic, Ragnhild Eek Brandlistuen, Mari Vaage Wang, Laurel Fish, Marialivia Bernardi, Jessica van de Grint‐Stoop, Mona Bekkhus, Pasco Fearon   +10 more
wiley   +1 more source

Gut microbiota may influence Sjögren's syndrome risk through immune cell mediation: A Mendelian randomization analysis. [PDF]

Medicine (Baltimore)
Yang J, Chen J, Huang L, Wang Z, Cheng Y.   +4 more
europepmc   +1 more source

Neuregulin 4‐dependent MAPK amplification mediates urate‐induced β‐cell dysfunction

Journal of Diabetes Investigation, EarlyView.
Hyperuricemia impairs glucose homeostasis by inducing pancreatic β‐cell apoptosis without insulin resistance. In male Uox‐KO mice, urate upregulates Nrg4, which amplifies MAPK signaling and drives β‐cell death. Thus, hyperuricemia disrupts glucose metabolism via the Nrg4‐MAPK axis.
Yunyang Wang, Kun Zhang, Zhiyuan Li, Shuhui Hu, Yiru Zhang, Yulei Zhao, Xiaohan Liu, Jie Lu   +7 more
wiley   +1 more source

Causal Mediation of Immune Cells and Fatty Acids in Coronary Atherosclerosis: Insights From Mendelian Randomization Analysis. [PDF]

Hum Mutat
Zhang Y, Xu J, Deng Z, Long X, Liu J, Jiang L, Liu N, Zhang D, Zhou W, Zhu P.   +9 more
europepmc   +1 more source

Network pharmacology and Mendelian randomization analysis to unravel the mechanism of Qingwen Baidu Decoction in sepsis treatment. [PDF]

Medicine (Baltimore)
Wang W, Ruan Y, Wu X, Li L, Liu N, Li Y.
europepmc   +1 more source

The mediating role of genes in the influence of intestinal flora on type 2 diabetes and the screening of diagnostic markers

Journal of Diabetes Investigation, EarlyView.
Using Mendelian randomization, TWAS/eQTL analysis, machine learning, and single‐cell RNA sequencing, this study identified gut microbiota taxa causally linked to type 2 diabetes, candidate mediator genes, and diagnostic markers (BEND7, BLVRA, C1orf85, and LAMC1).
Yu‐yang Chen, Yi‐fan Shi, Xin‐yue Zhang, Jing‐yue Zhang, Shi‐mao Zhang, Heng‐xia Zhao, De‐liang Liu   +6 more
wiley   +1 more source

Insights into the effects of gut microbiota and circulating metabolites on oral cancer: Mendelian randomization analysis and clinical validation. [PDF]

Front Nutr
Guo J, Guo J, Yang S, Guo Y, Huang J, Li P, Tang Y, Yang Y, Zheng W, He H.   +9 more
europepmc   +1 more source

Cardiac structure and function in psoriasis: A cross‐sectional analysis of the PSOCADIA study

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Individuals with well‐treated psoriasis exhibited a higher burden of myocardial dysfunction (GLS < 16%) compared with controls, independent of cardiometabolic comorbidity. The prevalence was similar across psoriasis severity, highlighting the importance of cardiovascular assessment in all patients with psoriasis. Abstract Background Psoriasis is linked
Maria Dons, Morten Sengeløv, Kristoffer Grundtvig Skaarup, Niklas Dyrby Johansen, Mats C. H. Lassen, Sofie Bøgh‐Sørensen, Filip Soeskov Davidovski, Julie Borchsenius, Peter Schnohr, Gorm Boje Jensen, Rasmus Møgelvang, Christoffer V. Nissen, Peter Riis Hansen, Brittany N. Weber, Claus Zachariae, Lone Skov, Tor Biering‐Sørensen   +16 more
wiley   +1 more source