Results 181 to 190 of about 23,652,556 (316)

Causal effects of blood and urinary biomarkers on cancer risk: A Mendelian randomization study

Journal of International Medical Research
Objective Observational studies have linked various serum and urinary biomarkers to cancer risk, but confounding and reverse causation limit causal inference.
Lina Leng, Ying Li
doaj   +1 more source

Mendelian randomization analysis results of simple mode and weighted mode methods.

Mendelian randomization analysis results of simple mode and weighted mode methods.
Puyu Liu (9620576), Lanlan Zhao (13930766), Qingqing Fu (10338083), Yao Chen (149006), Jihang Luo (9620573), Chengfang Li (8539437), Xiaorong Yang (265168), Jieyu Xu (15277931)   +7 more
core   +1 more source

Sickle Cell Disease: Historical Overview and Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide, yet the limited treatment options currently available do not always adequately control the disease and carry significant side effects. At present, the only curative treatment is hematopoietic stem cell (HSC) transplantation, a procedure that carries considerable challenges and numerous ...
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Genome‐Wide NIPT With Fetal‐Fraction Enrichment and BinDel: Clinical Cohort Evaluation of Microdeletion and ‐Duplication Detection

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective To evaluate the analytical and clinical performance of fetal fraction (FF) enriched genome‐wide noninvasive prenatal testing (GW‐NIPT) for the detection of clinically relevant copy number variants (CNVs) down to 1 Mb. Methods We retrospectively analyzed 10,501 singleton pregnancies tested with FF enrichment‐based GW‐NIPT between ...
Karmen Vaiküll, Priit Paluoja, Signe Mölder, Vadym Gryshchenko, Neeme Tõnisson, Andres Salumets, Kaarel Krjutškov   +6 more
wiley   +1 more source

Mendelian randomization analysis of individual SNPS (with cholesterol in small LDL as the outcome).

Mendelian randomization analysis of individual SNPS (with cholesterol in small LDL as the outcome).
Jiayi Zhang (5470265), Wenbo Wang (300277), Yujie Li (294983), Yufeng Zhang (195768), Xin Wang (91924), Fengyi Zhang (805423)   +5 more
core   +1 more source

Atopic dermatitis and attention‐deficit/hyperactivity disorder comorbidity in children and adolescents: Epidemiology, mechanisms, and clinical management

Pediatric Investigation, EarlyView.
This review synthesizes epidemiological evidence linking atopic dermatitis to attention‐deficit/hyperactivity disorder in children, proposes an “inflammation‐itch‐neurobehavioral axis” integrating sleep disruption, neuroendocrine dysregulation, and emerging neuro‐immune circuits, and outlines multidisciplinary management strategies targeting both skin ...
Qingyang Zhao, Yuan Liang, Ying Liu, Chunping Shen, Mutong Zhao, Jing Tian, Lei Jiao, Jing Sun, Ying Gu, Qiong Wu, Shan Wang, Lin Ma   +11 more
wiley   +1 more source

Deciphering argumentation on the regulation of genome‐edited crops in academic publications: A systematic review

PLANTS, PEOPLE, PLANET, EarlyView.
Genome editing technologies such as CRISPR‐Cas are reshaping debates about the future of agriculture, yet disagreement over how these crops should be regulated remains widespread. This study clarifies the range of arguments used in scientific discussions about genome‐edited crops, making underlying assumptions and value judgements more visible.
Philippe Mathys, Marco De Pascali Pepe, Bernice Elger, Bettina M. Zimmermann   +3 more
wiley   +1 more source

Levodopa and Melanoma: Practical Recommendations for Parkinson's Disease—International Parkinson and Movement Disorder Society Scientific Issues Committee Viewpoint

Movement Disorders Clinical Practice, EarlyView.
Giorgia Sciacca, Inas Elsayed, Santiago Perez‐Lloret, Tiago F. Outeiro, Vivek K. Unni, Jeffery H. Kordower, Daniela Berg, Lorraine V. Kalia, on behalf of the MDS Scientific Issues Committee, Jane Alty, Alexander Balck, Daniela Berg, Per Borghammer, Inas Elsayed, Yue Huang, Walaa Kamel Elsayed, Jeffrey Kordower, Alexander Lehn, Michele Matarazzo, Tiago Mestre, Tiago Outeiro, Gian Pal, Santiago Perez Lloret, Roopa Rajan, Sephira Ryman, Giorgia Sciacca, Per Svenningsson, Lorraine Kalia   +27 more
wiley   +1 more source

From prediction to intervention: Causal artificial intelligence as the missing link in precision therapeutics

Precision Medical Sciences, EarlyView.
Predictive multiomics artificial intelligence (AI) identifies risk but does not indicate which intervention will change a patient's outcome; causal AI, anchored in biological mechanism, bridges this gap to enable individualized treatment decisions.
Gedion Mengistu Dejen
wiley   +1 more source

Mendelian randomization analysis of individual SNPS (with concentration of small LDL particles as the outcome).

Mendelian randomization analysis of individual SNPS (with concentration of small LDL particles as the outcome).
Jiayi Zhang (5470265), Wenbo Wang (300277), Yujie Li (294983), Yufeng Zhang (195768), Xin Wang (91924), Fengyi Zhang (805423)   +5 more
core   +1 more source