Results 201 to 210 of about 42,228 (267)

Periodontitis and Diabetes: Mechanistic Evidence of a Circular Relationship

Journal of Periodontal Research, EarlyView.
This narrative review aimed to explore the underlying mechanisms that connect periodontitis to diabetes (and vice versa) and that influence disease susceptibility, progression and response to treatment. ABSTRACT The circular relationship between periodontitis and diabetes mellitus is one of the most established oral‐systemic links.
Philip M. Preshaw, Ren Jie Jacob Chew, Charlene Enhui Goh, Ali A. Abdulkareem, Dana T. Graves   +4 more
wiley   +1 more source

Bidirectional Mendelian randomization analysis of hypertension, coronary artery disease, and gastric cancer with supplementary clinical data. [PDF]

Front Cardiovasc Med
Ma Q, Kong YF, Li AL, Song LN, Tian YM.
europepmc   +1 more source

Viruses, Periodontitis, and Systemic Diseases

Journal of Periodontal Research, EarlyView.
This narrative review aimed to summarize current evidence on the viral involvement in periodontitis and its relevance for systemic diseases. The oral cavity acts as an active viral reservoir and dissemination platform, where virus–microbiome interactions may promote dysbiosis, periodontitis progression, and systemic inflammatory effects, while the ...
Kim Natalie Solte, Yvonne L. Hernandez‐Kapila, Henrik Dommisch   +2 more
wiley   +1 more source

Malignant neoplasm of skin with risk of sepsis: A bidirectional Mendelian randomization analysis. [PDF]

Medicine (Baltimore)
Pan L, Hu J.
europepmc   +1 more source

Causal Inference in Clinical Research: A Primer

Journal of Periodontal Research, EarlyView.
Causal inference helps researchers move beyond describing associations to answering the question: what would happen if an exposure were changed? This article provides an intuitive overview for applied researchers. ABSTRACT The study of causal relationships is central to scientific inquiry. Understanding what disease is, why it arises, and how it can be
Nasir Z. Bashir, Moritz Kebschull, Stephen Burgess, Gustavo G. Nascimento   +3 more
wiley   +1 more source

Integrated transcriptomic, molecular docking, and mendelian randomization analysis reveal a microbial-propionate-JUN pathway in renal ischemia-reperfusion injury. [PDF]

Virulence
Li J, Huang R, Wang X, Zhang Y, Xu Z, Zhang P, Hu H.   +6 more
europepmc   +1 more source

Genomic Evidence on Antihypertensive Drug Targets and Oral Disease Outcomes

Journal of Periodontal Research, EarlyView.
Key Findings Drug‐target Mendelian randomization showed little evidence that genetically proxied on‐target pharmacological actions of most antihypertensive drug classes were associated with chronic periodontitis or dental caries. The diazoxide–periodontitis association requires cautious interpretation, given possible residual pleiotropy at KCNJ11 and ...
Aiswarya Puzhakkara Chennas, Ignacio Leiva‐Escobar, Stefan Lars Reckelkamm, Birte Holtfreter, Thomas Kocher, Sebastian‐Edgar Baumeister, Michael Nolde, Zoheir Alayash   +7 more
wiley   +1 more source

The causality between dietary intake and allergic diseases: A two-sample Mendelian randomization analysis. [PDF]

Medicine (Baltimore)
Liu W, Mao C, Ji H, Cheng F, Li T, Li Q, Zhao C, An Y.   +7 more
europepmc   +1 more source

Sleep Improvement for Metabolic Health: A Feasibility Trial of a Digital Sleep Treatment in People With Insomnia and Non‐Diabetic Hyperglycaemia

Journal of Sleep Research, EarlyView.
ABSTRACT Insomnia may play a causal role in type 2 diabetes (T2D). Addressing insomnia through cognitive behavioural therapy (CBTi) in people with non‐diabetic hyperglycaemia could potentially reduce the risk of progression to T2D. To inform a future randomised trial, we performed a feasibility study of digital CBT (dCBTi) in individuals at increased ...
Rachel Sharman, David Ray, Andrew Farmer, Poppy C. E. Green, Victoria Harris, Fredrik Karpe, Colin A. Espie, Diana Mantripp, Thomas Marjot, Niall M. McGowan, Jeremy W. Tomlinson, Simon D. Kyle   +11 more
wiley   +1 more source