Mendelian randomization analysis

Results 201 to 210 of about 23,652,556 (316)

Fingered Citron Extract Ameliorates Diabetes‐Related Depression via Targeting SRC‐Mediated Insulin Signaling and Neuroinflammation

Phytotherapy Research, EarlyView.
ABSTRACT Diabetes‐related depression (DD) is a challenging comorbidity characterized by self‐reinforcing interactions between metabolic dysfunction and affective disturbance, while conventional antidepressants and glucose‐lowering drugs often yield suboptimal outcomes with adverse effects.
Shun Guo +5 more
wiley +1 more source

Mendelian randomization analysis of inflammatory proteins and lung adenocarcinoma risk. [PDF]

Discov Oncol
Tan H, Ma S, Liu Y.
europepmc +1 more source

Gut microbiota dysbiosis in the inflammatory pathogenesis of diabetic retinopathy

VIEW, EarlyView.
This graphical abstract illustrates how gut dysbiosis drives diabetic retinopathy through the gut‐retina axis, a process unfolding in three interconnected stages. First, in the gut, a decrease in beneficial bacteria and an increase in pro‐inflammatory taxa compromise the intestinal barrier, causing a “leaky gut” that allows LPS to translocate into the ...
Junyan Hu, Jingxiang Zhong
wiley +1 more source

The causal relationship between diabetes mellitus and hashimoto thyroiditis: A two-sample mendelian randomization analysis. [PDF]

Medicine (Baltimore)
Song Y, He Y, Qin L, Liu T.
europepmc +1 more source

Gastritis and age‐related macular degeneration: Potential roles of metabolomic dysregulation and photoreceptor alterations

VIEW, EarlyView.
Abstract Age‐related macular degeneration (AMD) is a degenerative retinal disorder and a leading cause of global visual impairment, yet effective treatments remain limited. While gastritis is a prevalent clinical condition among older populations and has been associated with adverse effects on the central nervous system, its potential association with ...
Jingxin Zhou +5 more
wiley +1 more source

Pharmacovigilance signal detection of rilonacept using FAERS with exploratory Mendelian randomization analysis. [PDF]

Int J Clin Pharm
Liu L, Chi Z, Zhang Z.
europepmc +1 more source

Integrative Analysis of Plasma Proteome and Genome Reveals Novel Drug Targets for Chronic Rhinosinusitis and Nasal Polyps

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) and nasal polyps (NP) are chronic inflammatory conditions with unsatisfactory treatment outcomes due to frequent recurrence of refractory disease. Identifying new therapeutic targets is essential. Methods We conducted a proteome‐wide Mendelian randomization (MR) analysis by integrating genome‐wide ...
En Zhou +4 more
wiley +1 more source

Viral infection and dementia risk: A systematic bidirectional Mendelian randomization analysis. [PDF]

Virus Res
Huang JW +5 more
europepmc +1 more source

Obstructive Sleep Apnea and BMI, Body Fat Percentage in the East Asian Population: A Bidirectional and Multivariate Mendelian Randomization Study

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective To explore the causal relationship between obstructive sleep apnea and body fat percentage and body mass index (BMI) in the East Asian population by using bidirectional Mendelian randomization and multivariate Mendelian randomization.
Rui Fan +5 more
wiley +1 more source

Identification of Novel Protein Biomarkers and Drug Targets for Acne Vulgaris by Integrating Human Plasma Proteome with Genome-Wide Association Data

Journal of Inflammation Research
Dongrui Xu,1,* Xiaoyi Yang,1,* Wenjuan Wu,2 Jiankang Yang1 1School of Basic Medical Sciences, Dali University, Dali, Yunnan, People’s Republic of China; 2Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming,
Xu D, Yang X, Wu W, Yang J
doaj

mendelian randomization
medicine general
gut microbiota

causal inference
causal relationship