Results 221 to 230 of about 42,228 (267)

How physiology solves the gene‐centric impasse

Experimental Physiology, EarlyView.
Abstract The criteria for distinguishing between association and causation in studies of genes and function are clarified. Genomic association scores alone cannot satisfy those criteria, which is why treatment of common diseases has not benefitted from the cures expected when the Human Genome Project was launched.
Denis Noble, Reine Bourret
wiley   +1 more source

Genetic Evidence Links Gestational Diabetes Mellitus to Increased ER-Negative Breast Cancer Risk Through a Mendelian Randomization Analysis. [PDF]

Int J Endocrinol
Peng W, Huang Z, Zhang M.
europepmc   +1 more source

Calcium‐activated chloride channels in pericytes and their role in regulating organ blood flow

The Journal of Physiology, EarlyView.
Abstract figure legend Pericytes are microvascular mural cells with diverse roles. Contractile pericytes directly regulate local perfusion, while non‐contractile pericytes coordinate upstream vascular contractility via propagating electrical signals.
Paolo Tammaro, Hikaru Hashitani
wiley   +1 more source

Mendelian randomization analysis of immune cell subsets and inflammatory cytokines in aplastic anaemia. [PDF]

Ann Hematol
Hu K, Cheng Y, Xiao G, Shen X, Zhu J, Huang M, Fei Y, Qian S, Shao X.   +8 more
europepmc   +1 more source

Anatomical and functional mapping of vagal nociceptive sensory nerve subsets innervating the mouse lower airways by intersectional genetics

The Journal of Physiology, EarlyView.
Abstract figure legend We used an intersectional approach with recombinase‐expressing mice and adeno‐associated virus to map and modulate distinct nociceptive afferents in the vagal ganglia. TRPV1+P2X2+ neurons resided in the nodose ganglion (N), innervated the lungs (many projected into the alveoli) but not the trachea, and projected to the nucleus ...
Mayur J. Patil, Justin Shane Hooper, Seol‐Hee Kim, Parmvir K. Bahia, Nika Pavelkova, Sanjay S. Nair, Teresa S. Darcey, Karina V. Lurye, Meghana Madaram, Jailene Fiallo, Stephen H. Hadley, Thomas E. Taylor‐Clark   +11 more
wiley   +1 more source

Bidirectional Mendelian randomization analysis of the causal association between obesity and hepatocellular carcinoma in a European population. [PDF]

Medicine (Baltimore)
Ding X, Zhou X, Tang N, Wang X, Jin X, Ma X, Wu B, Wu C, Yang X, Yang J, Wu T, Liang Q, Yin L.   +12 more
europepmc   +1 more source

Derivation and Validation of a Predictive Model for Advanced Colorectal Neoplasia Among Average‐Risk Adults in China

International Journal of Cancer, Volume 159, Issue 6, Page 1455-1463, 15 September 2026.
Efficient pre‐colonoscopy risk stratification tools are needed, especially in China. Using multicenter colorectal cancer screening data from Shandong Province, the authors developed and validated a risk prediction model for advanced colorectal neoplasia in asymptomatic individuals using sociodemographic characteristics, lifestyle factors, and medical ...
Yan Liu, Yanxiu Liu, Yukun Feng, Boyu Liu, Wenxuan Yan, Nan Zhang, Youhua Lu   +6 more
wiley   +1 more source

The influence of unhealthy lifestyle on semen quality: results from a cross-sectional study and Mendelian randomization analysis. [PDF]

Ann Med Surg (Lond)
Lin M, Feng Y, Zhang Y, He Q, Feng N.
europepmc   +1 more source

Exploratory Mendelian randomization analysis: The genetic susceptibility of CT examination preference and the risk of hypertrophic cardiomyopathy. [PDF]

Medicine (Baltimore)
Dong Q, Han B, Wang N.
europepmc   +1 more source

Causal relationship between inflammatory proteins and attention deficit hyperactivity disorder: A serum-metabolites-mediated Mendelian randomization analysis. [PDF]

Medicine (Baltimore)
Zhou K, Zhang Q, Liu M, Yan Y, Wang J.
europepmc   +1 more source