Results 241 to 250 of about 23,652,556 (316)

Association of gestational diabetes with other lactation-related disorders: A 2-sample Mendelian randomization analysis of causal effects. [PDF]

Medicine (Baltimore)
Yang C, Song W, Lu K, Dang W, Li J, Wang Y, Zhang M, Cheng X, Wu X.   +8 more
europepmc   +1 more source

MD‐1 Deficiency Mitigates Atherosclerosis by Inhibiting NLRP3 Inflammasome Activation via cGAS‐STING Dependent Pathway in Macrophages

Cell Proliferation, EarlyView.
MD‐1 is induced and activated in macrophages. The activated MD‐1 subsequently promotes the cGAS‐STING‐TBK1‐IRF3 signalling pathway to activate the NLRP3 inflammasome, and subsequently increases pro‐inflammatory macrophage polarisation and decreases plaque stability to accelerate the development of atherosclerosis.
Fang Zhao, Zhili Jin, Zhiwei Cai, Quan Zhang, Tao He, Xiangjie Kong, Ming Chen, Zhibing Lu, Xiaorong Hu, Wen‐Lin Cheng   +9 more
wiley   +1 more source

Genetics‐Informed Pharmacological Intervention in Gestational Diabetes Mellitus: Current Therapeutic Alignment, Emerging Targets and a Translational Roadmap

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Gestational diabetes mellitus (GDM) complicates roughly one in seven pregnancies and predicts later maternal type 2 diabetes mellitus (T2DM). Yet its pharmacological management still rests on a handful of agents (insulin, metformin and glibenclamide), none of them selected on the basis of the disease's molecular genetics.
Wael Osman
wiley   +1 more source

Metformin Use During Pregnancy and Early‐Life Nutritional Status: A Systematic Review of Randomized Clinical Trials

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background and Aims Metformin is increasingly used to treat gestational diabetes mellitus and other insulin‐resistant conditions during pregnancy. Because it crosses the placenta, concerns remain regarding its potential effects on offspring growth and metabolic programming.
Otilia Perichart‐Perera, Larissa Hernández‐Hernández, Ameyalli M. Rodríguez‐Cano   +2 more
wiley   +1 more source

RLIM‐associated neurodevelopmental disorders: From clinical spectrum to molecular mechanisms

The FEBS Journal, EarlyView.
RLIM (RNF12) is an E3 ubiquitin ligase essential for mammalian development. Loss‐of‐function variants cause Tønne–Kalscheuer syndrome, while duplications cause Xq13 duplication syndrome, highlighting RLIM dosage sensitivity. This review summarizes the genetics, clinical features, and molecular mechanisms of RLIM‐associated disorders, integrating ...
Madison Landon, Kyra Swildens, Vera M. Kalscheuer, Cristina Gontan, Francisco Bustos   +4 more
wiley   +1 more source

Preserved B Cell Function in CD23‐Cre Transgenic Mice Allows Reliable Flox‐Only Controls in Mouse Models

Immunology, EarlyView.
Expression of CD23‐Cre does not impair the function of mature B cells or the establishment of the humoral immune response. Therefore, Flox‐only mice are suitable controls in studies using a CD23‐Cre mouse model. This reduces the number of surplus animals generated and supports the 3Rs principle in animal research.
Leonie Steinmetzer, Franziska Rost, Christina B. Brunner, Daniel Ehrenschwender, Theresa Lauterbach, Theresa E. H. Bierling, Chiara Vlad, Michèle Ohnemüller, Hannah Elaine Smid, Daniel Hosp, Dirk Mielenz, Wolfgang Schuh, Katharina Pracht   +12 more
wiley   +1 more source

Evaluating Selection Strategies Based on Inbreeding Load via Simulation

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT Inbreeding load is the fraction of the mutation load that is due to recessive action of mutations. This load is only expressed in individual's inbred offspring. As such, inbreeding load contributes to genetic heterogeneity among individuals and can thus be used as a criterion of selection.
Simona Antonios, Jana Obšteter, Ivan Pocrnic, Gregor Gorjanc, Silvia T. Rodríguez‐Ramilo, Zulma G. Vitezica   +5 more
wiley   +1 more source

A Transformation From Methane Concentration From Sniffers to Methane Production for Implementation in Breeding Programs and Comparison With Tier 2 Equation

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT Reducing methane emissions from dairy cattle has gained considerable attention due to its dual benefits of improving feed efficiency and mitigating climate change. Consequently, phenotyping methane emissions in dairy populations has become increasingly important to enable direct genomic selection for lower methane emissions in breeding ...
O. González‐Recio, E. Teran, J. A. Jiménez‐Montero, C. I. V. Manzanilla‐Pech, B. Gredler‐Grandl   +4 more
wiley   +1 more source

Diagnosed Dental Diseases, Tooth Loss and the Risk of Primary Liver Cancer in a Nationwide Swedish Cohort

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Background and Aim Poor dental health has been shown to increase the risk of several types of cancer, but its association with primary liver cancer (PLC) remains unclear. We aimed to evaluate the association between dental diseases, tooth loss and the risk of PLC.
Qiaofeng Zhong, Zengliang Ruan, Li Yin, Hans‐Olov Adami, Weimin Ye   +4 more
wiley   +1 more source

Puberty timing and cognitive functioning: insights from the Adolescent Brain Cognitive Development (ABCD) study and Mendelian randomization

Journal of Child Psychology and Psychiatry, EarlyView.
Background Early puberty timing is linked to altered neurodevelopment and adverse mental health outcomes, yet its relationship with cognitive functioning remains unclear. We examined the effects of puberty timing across multiple cognitive domains.
Lars Dinkelbach, Bianca Serio, Sofie Valk, Franka Edith Weisner, Luise Margaretha Bläschke, Triinu Peters, Anke Hinney, Börge Schmidt, Raphael Hirtz   +8 more
wiley   +1 more source