Results 241 to 250 of about 42,228 (267)

Obesity and peripheral arterial disease: A Mendelian Randomization analysis

Atherosclerosis, 2016
Observational studies showed that obesity is a major risk factor for peripheral arterial disease (PAD). However, conventional epidemiology studies are vulnerable to residual bias from confounding factors. We aimed to explore the causality of obesity in development of PAD using Mendelian Randomization (MR) approach.A MR analysis was performed in 11,477 ...
Ya, Huang, Min, Xu, Lan, Xie, Tiange, Wang, Xiaolin, Huang, Xiaofei, Lv, Ying, Chen, Lin, Ding, Lin, Lin, Weiqing, Wang, Yufang, Bi, Yimin, Sun, Yifei, Zhang, Guang, Ning   +13 more
openaire   +2 more sources

PM2.5 associates with blood pressure: a Mendelian randomization analysis

International Journal of Environmental Health Research
The relationship between fine particulate matter (PM2.5) and blood pressure (BP) is a controversial issue. We conducted a two-sample Mendelian randomization (MR) analysis and identified 58 genome-wide significant single-nucleotide polymorphisms associated with PM2.5 as instrument variables.
Minghui, Bao, Haotong, Li, Yan, Zhang, Jianping, Li   +3 more
openaire   +2 more sources

Integration of latent factor analysis into multivariable Mendelian randomization

European Journal of Epidemiology
Mendelian randomization has emerged as a powerful tool for exploring causal relationships in observational studies by using genetic variants as instrumental variables. While multivariable Mendelian randomization extends this approach to simultaneously address multiple exposures, it faces significant challenges with highly correlated exposures ...
Yuankai Zhang, Roby Joehanes, Tianxiao Huan, Lukas M. Weber, Qiong Yang, Kathryn L. Lunetta, Daniel Levy, Chunyu Liu   +7 more
openaire   +2 more sources

Apolipoprotein and peripheral artery disease: Mendelian randomization analysis

Vascular
Background The prevalence of peripheral arterial disease (PAD) is on the rise globally, leading to adverse clinical outcomes. Our aim was to investigate the causal relationship between apolipoprotein and PAD, as well as the potential mediating role of smoking, diabetes, hypertension, myocardial infarction, and ...
Chen-Xin Wan, Yu-Shu Gong, Tao Xu
openaire   +2 more sources

Testing and correcting for weak and pleiotropic instruments in two‐sample multivariable Mendelian randomization

Statistics in Medicine, 2021
Eleanor Sanderson, Jack Bowden
exaly  

Dyslipidemia and Risk of Preeclampsia: A Multiancestry Mendelian Randomization Study

Hypertension, 2023
Hillary Hosier, Humaira Rasheed, Andrew Dewan   +2 more
exaly  

Appraising the causal role of smoking in multiple diseases: A systematic review and meta-analysis of Mendelian randomization studies

EBioMedicine, 2022
Stephen Burgess, Susanna C Larsson
exaly  

Two‐Sample Multivariable Mendelian Randomization Analysis Using R

Current Protocols, 2021
Gina Peloso
exaly  

Kidney damage causally affects the brain cortical structure: A Mendelian randomization study

EBioMedicine, 2021
, Xiayao Diao, Tianxin Lin
exaly  

C-Reactive Protein Levels and Risk of Cardiovascular Diseases: A Two-Sample Bidirectional Mendelian Randomization Study

International Journal of Molecular Sciences, 2023
Ahmed Abdel-Latif, Himi Tripathi, Ahmed Al-Darraji   +2 more
exaly