ABSTRACT Aims This study aimed to examine the associations of maternal first‐trimester atherogenic index of plasma (AIP) with gestational diabetes mellitus (GDM) and birth weight outcomes, and the mediating role of second‐trimester blood glucose. Methods This prospective cohort study included 5,706 pregnant women without pre‐existing diabetes or other ...
Doudou Zhao +8 more
wiley +1 more source
Exploring the role of gut microbiota in coronary atherosclerosis through lipoprotein-mediated cholesterol transport and distribution: A Mendelian randomization analysis. [PDF]
Liu X, Shen K, Zhu F, Cheng C, Yu H.
europepmc +1 more source
Cardiac structure and function in psoriasis: A cross‐sectional analysis of the PSOCADIA study
Individuals with well‐treated psoriasis exhibited a higher burden of myocardial dysfunction (GLS < 16%) compared with controls, independent of cardiometabolic comorbidity. The prevalence was similar across psoriasis severity, highlighting the importance of cardiovascular assessment in all patients with psoriasis. Abstract Background Psoriasis is linked
Maria Dons +16 more
wiley +1 more source
Dual-Axis Pattern of Peripheral Immunity in Myasthenia Gravis Susceptibility: A Prospective Cohort Study and Mendelian Randomization Analysis. [PDF]
Lei J, Huang H, Chen J, Huang X, Feng H.
europepmc +1 more source
Modulation of sebocyte function in acne: A pathway‐inclusive review
Acne is multifactorial, with the sebocyte acting as a central immunometabolic hub linking lipogenic, inflammatory, hormonal and barrier pathways. Mapping established and investigational therapies onto this sebocyte‐centred model offers a mechanism‐based framework that complements existing treatment paradigms and may guide more targeted, antibiotic ...
Christos C. Zouboulis +3 more
wiley +1 more source
Unveiling novel drug targets for atherosclerosis: A Mendelian randomization analysis. [PDF]
Du W +6 more
europepmc +1 more source
Pathogenesis of hidradenitis suppurativa: From susceptibility to chronicity
This review describes hidradenitis suppurativa as a heterogeneous disorder in which genetic susceptibility, epithelial dysfunction, environmental exposures, immune activation and microbial ecology converge differently across patients and disease stages.
Kelsey R. van Straalen +5 more
wiley +1 more source
Retraction Note: Real-world data and Mendelian randomization analysis in assessing adverse reactions of rilonacept. [PDF]
Liu L, Chi Z, Zhang Z.
europepmc +1 more source
Obesity‐associated transcriptomic remodelling in hidradenitis suppurativa and treatment response
This review highlights that adiposity systemically primes HS through adipokine dysregulation and insulin resistance, contributing to lesional metabolic reprogramming and perilesional barrier dysfunction. Current evidence indicates that obesity exacerbates disease severity and attenuates responses to biologic therapies, supporting the classification of ...
Sahil Kapur +9 more
wiley +1 more source

