Results 231 to 240 of about 23,652,556 (316)

Dystrophia Smolandiensis is characterized by a novel NQO1 variant and a distinct phenotype from COL17A1‐associated epithelial recurrent erosion dystrophy

Acta Ophthalmologica, EarlyView.
Abstract Purpose To determine the molecular cause of the two epithelial recurrent erosion dystrophies, Dystrophia Smolandiensis and Dystrophia Helsinglandica, and to identify phenotypic differences between the two conditions. Methods DNA samples and clinical data from structured interview records were obtained from the Swedish families in which ...
Karl De Geer, Kristina Lagerstedt‐Robinson, Daniel Nilsson, Cilla Söderhäll, Björn Hammar, Erik Björck   +5 more
wiley   +1 more source

Blood pressure and intraocular pressure in the Canadian Longitudinal Study on Aging: a bidirectional Mendelian randomization analysis. [PDF]

Front Genet
Bastasic J, Rakesh M, Freeman EE, Little J, Burkett KM, Roy-Gagnon MH.   +5 more
europepmc   +1 more source

A Two-Sample Mendelian Randomization Analysis of the Oral Microbiome and Oral/Oropharyngeal/Tongue Cancers

A Two-Sample Mendelian Randomization Analysis of the Oral Microbiome and Oral/Oropharyngeal/Tongue Cancers ——Supplementary ...
Zhifa Wang
core  

Higher plasma vitamin D levels are not causally associated with less age‐related macular degeneration

Acta Ophthalmologica, EarlyView.
Abstract Purpose Higher levels of plasma 25‐hydroxyvitamin D have been associated with a lower risk of age‐related macular degeneration (AMD). We investigated observational and potential causal associations of plasma 25‐hydroxyvitamin D with the risk of AMD in two large contemporary population‐based prospective studies and a genetic case–control ...
Sabina O. Beheshti, Michael Larsen, Børge G. Nordestgaard, Shoaib Afzal   +3 more
wiley   +1 more source

Genetic Links Between Cancer and Coronary Atherosclerosis: A Mendelian Randomization Analysis. [PDF]

Hum Mutat
Fan Y, Liu M, Zhang L, Liu F, Dong J, Zhang M, Zhang L, Sun Y, Yao W, Geng W.   +9 more
europepmc   +1 more source

Defining Age to Screen and Real‐World Effectiveness for Early‐Onset Colorectal Cancer

Cancer Science, EarlyView.
Implementation of a RAP‐based risk‐adapted screening strategy enables personalized screening initiation, with benefits comparable to those observed in the current 50–54‐year age group.
Le Wang, Yu Qiu, Xuechen Chen, Weimiao Wu, Chen Zhu, Weiwei Chen, Tingting Pan, Dong Hang, Lingbin Du   +8 more
wiley   +1 more source

The causal relationship between serum metabolites and the development of infertility: A Mendelian randomization analysis. [PDF]

Medicine (Baltimore)
Zhang Y, Ma S, Wang T, Hu J, Gao Y, Yu W, Liu W, Wang Y, Zhang C, Sun Z.   +9 more
europepmc   +1 more source

Triangulating Evidence on Serum Uric Acid and Cancer Risk: Consistent Inverse Associations With Lung Cancer

Cancer Science, EarlyView.
Using both conventional observational and Mendelian randomization (MR) analyses in the same Japanese community‐dwelling population, the evidence consistently supported an inverse association between the serum uric acid level and lung cancer risk. ABSTRACT We examined the association between serum uric acid (UA) levels and cancer incidence through a ...
Takashi Matsunaga, Kenji Wakai, Takashi Tamura, Mako Nagayoshi, Rieko Okada, Itsuki Kageyama, Megumi Hara, Takuma Furukawa, Hiroaki Ikezaki, Yuji Matsumoto, Takeshi Nishiyama, Hiroko Nakagawa‐Senda, Chihaya Koriyama, Shiroh Tanoue, Naoyuki Takashima, Etsuko Ozaki, Katsuyuki Miura, Aya Kadota, Takeshi Watanabe, Masashi Ishizu, Kiyonori Kuriki, Masahiro Nakatochi, Yukihide Momozawa, Issei Imoto, Isao Oze, Keitaro Matsuo, the J‐MICC Study Group   +26 more
wiley   +1 more source

Immune cell phenotypes in the context of diabetic nephropathy: A Mendelian randomization analysis. [PDF]

Medicine (Baltimore)
Tong K, Deng J, Yu Y, Xiang Q, Wu J, Pan W, Huang J.   +6 more
europepmc   +1 more source

Macrophage Lipid Homeostasis Drives IVDD via a Senescence‐Dependent Impairment of Efferocytosis

Cell Proliferation, EarlyView.
Intervertebral disc degeneration (IVDD) has been a leading cause of low back pain and lacks disease‐modifying therapies. Although dysregulated disc lipid metabolism is implicated, its impact on the immune microenvironment, particularly macrophages, remains unknown.
Jinyu Wang, Shiyong Ling, Qi Wang, Xuege Qiao, Jianpeng Xing, Siyang Ji, Linhui Han, Chen Yan, Zhishen Niu, Lei Yuan, Baolian Zhao, Kaiqiang Sun, Jiangang Shi   +12 more
wiley   +1 more source