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Association of ophthalmic diseases with stroke: cohort study and Mendelian randomization analysis. [PDF]

Arch Med Sci
Li C, Chen J, Li K, Zhang S, Zhu S.
europepmc   +1 more source

Bidirectional Mendelian Randomization Analysis Reveals Causal Associations Between Autoimmune Diseases and Colorectal Cancer. [PDF]

World J Oncol
Liu S, Chen K, Wang YQ, Gu XY, He Z, Zhang C, Wu GQ, Luo SS, Jin X.   +8 more
europepmc   +1 more source

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Depression and sarcopenia: a Mendelian randomization analysis

Psychiatric Genetics, 2023
Background The association between depression and sarcopenia has been reported in observational studies but the causality of depression on sarcopenia remained unknown. We aimed to assess the causal effect between major depressive disorder (MDD) and sarcopenia using the two-sample Mendelian randomization (MR) method.
Yehong, Lu, Ruijie, Zhang, Qiang, Zheng
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A General Approach to Sensitivity Analysis for Mendelian Randomization

Statistics in Biosciences, 2020
Mendelian Randomization (MR) represents a class of instrumental variable methods using genetic variants. It has become popular in epidemiological studies to account for the unmeasured confounders when estimating the effect of exposure on outcome. The success of Mendelian Randomization depends on three critical assumptions, which are difficult to verify.
Weiming, Zhang, Debashis, Ghosh
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On Mendelian randomization analysis of case‐control study

Biometrics, 2019
AbstractMendelian randomization (MR) analysis uses genotypes as instruments to estimate the causal effect of an exposure in the presence of unobserved confounders. The existing MR methods focus on the data generated from prospective cohort studies. We develop a procedure for studying binary outcomes under a case‐control design.
Han Zhang, Jing Qin, Sonja I. Berndt, Demetrius Albanes, Lu Deng, Mitchell H. Gail, Kai Yu   +6 more
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Adiposity and cancer: a Mendelian randomization analysis in the UK biobank

International Journal of Obesity, 2021
Observational and Mendelian randomization (MR) studies link obesity and cancer, but it remains unclear whether these depend upon related metabolic abnormalities.We used information from 321,472 participants in the UK biobank, including 30,561 cases of obesity-related cancer.
Muktar Ahmed, Anwar Mulugeta, S. Hong Lee, Ville-Petteri Mäkinen, Terry Boyle, Elina Hyppönen   +5 more
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Daytime sleepiness and risk of stroke: A Mendelian randomization analysis

Clinical Neurology and Neurosurgery, 2021
Daytime sleepiness is known to be related to stroke, but whether daytime sleepiness is a risk factor for stroke remains unclear. We conducted a two-sample Mendelian randomization study to assess the relationship between daytime sleepiness and stroke, ischemic stroke (IS) and IS subtypes.Thirty-six single-nucleotide polymorphisms (SNPs) associated with ...
Yazhou, Ma, Mengmeng, Wang, Xin, Chen, Wang, Ruan, Jianrong, Yao, Xuegan, Lian   +5 more
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