Results 101 to 110 of about 22,084,160 (163)

Inflammation and keratoconus: A comprehensive bidirectional Mendelian randomization analysis

Medicine
An increasing body of evidence supports the involvement of inflammation and immune responses in the occurrence and development of keratoconus (KC). However, the causal relationship between inflammatory factors and KC remains unclear. We employed a 2-way Mendelian randomization (MR) approach to investigate the interaction between KC and inflammatory ...
Zhang, Xueyan, Cui, Fenghua, Wang, Qiaoling, Zhang, Chenming   +3 more
openaire   +2 more sources

Causal association of plasminogen activators and their inhibitors with Alzheimer’s disease: a Mendelian randomization study

Archives of Medical Science
Introduction Alzheimer’s disease (AD) is the most common cause of dementia and contributes to a huge burden of disease worldwide. Observational studies have found that tissue plasminogen activator (t-PA) inhibits the development of AD, but little is ...
Xin Guo, Fangyu Gao, Baolong Pan, Feng Gao, Jingsi Zhang, Shanshan Wang, Qiao Niu   +6 more
doaj   +1 more source

Mendelian randomization analysis of female reproductive factors on osteoarthritis

Medicine
Epidemiology shows women have a higher incidence of osteoarthritis (OA) than men. However, there is not enough evidence to suggest a direct correlation between female reproductive factors and OA. Therefore, this study will employ Mendelian randomization (MR) analysis to investigate whether there is a causal relationship between the 2. This study used a
Pang, Liang, Wu, Kai, Su, Pingping, Liao, Zhicheng, Lv, Cunxian   +4 more
openaire   +2 more sources

Evaluation of the Association Between Postpartum Hemorrhage and Antidepressant Use: A Mendelian Randomization Study

Drugs - Real World Outcomes
Background The relationship between antidepressants, depression, and the incidence of postpartum hemorrhage (PPH) has been reported in observational studies, but the causal link between these factors remains unknown.
Zhenzhen Chen, Qingqing Lv, Shiteng Lin, Wanlong Lin, Wei Zhuang   +4 more
doaj   +1 more source

Schematic representation of the Mendelian randomization analysis.

The continuous lines represent the relationships that hold in MR analysis. Broken lines represent associations that violate the assumptions of Mendelian randomization.
Rui Wang (52434), Xu Luo (180879), YunXiang Zhou (18120934), Wen Xie (104834)   +3 more
core   +1 more source

Causality between immunocytes and polymyositis: A Mendelian randomization analysis

Medicine
Polymyositis is a prominent subgroup of idiopathic inflammatory myopathy, considered to have an autoimmune etiology. However, research exploring the condition between immunocytes and polymyositis remains limited, indicating the need for further investigation to unravel these intricate associations. We employed bidirectional Mendelian randomization (MR)
Ni Yang, Chang Li, Ruhui Liu, Xianghua Qi, Xing Qian   +4 more
openaire   +2 more sources

Gut microbiota influences colorectal cancer through immune cell interactions: a Mendelian randomization study

Discover Oncology
Background Colorectal cancer (CRC) is the most prevalent malignant tumor of the digestive system globally, posing a significant threat to human health and quality of life.
Linyi Zheng, Yuqiang Li, Cenap Güngör, Heming Ge   +3 more
doaj   +1 more source

Juvenile idiopathic arthritis and primary ovarian failure: a two-sample Mendelian randomization analysis in a mixed-gender cohort

Frontiers in Endocrinology
BackgroundThe causal relationship between juvenile idiopathic arthritis (JIA) and primary ovarian failure (POF) remains uncertain. To elucidate this relationship, we employed a two-sample Mendelian randomization analysis.MethodsThe single nucleotide ...
Yuanhang Mo, Anquan Shang, Guoguo Wei, Donghui Xu, Yuxi Hou, Xiaowen Shao, Chaoyan Yue   +6 more
doaj   +1 more source

Mendelian randomization analysis of druggable gene expression in liver cancer risk and autoimmune hepatitis

Discover Oncology
Background Liver cancer remains one of the most prevalent and lethal malignancies worldwide, while autoimmune hepatitis is an immune-mediated inflammatory liver disease characterized by circulating autoantibodies and distinctive histopathological ...
Mingming Lian, Jun Yao
doaj   +1 more source

Dietary factors and risk for endometriosis: a Mendelian randomization analysis

Nutrition & Metabolism
Abstract Aims Observational studies have reported an association between dietary factors and endometriosis, but the causality remains unknown. The study aimed to evaluate the potential causal effect of dietary factors on endometriosis. Methods We performed a two-sample Mendelian randomization (MR) analysis to investigate the effects of 18 diet ...
Zhang, Xia, Zheng, Qiaomei, Chen, Lihong
openaire   +2 more sources