Results 91 to 100 of about 70,702 (197)

Periodontitis and osteoporosis: a two-sample Mendelian randomization analysis

Brazilian Journal of Medical and Biological Research
The incidences of periodontitis and osteoporosis are rising worldwide. Observational studies have shown that periodontitis is associated with increased risk of osteoporosis. We performed a Mendelian randomization (MR) study to genetically investigate the causality of periodontitis on osteoporosis.
Jiale Wu, Lihui Yao, Yuchen Liu, ShuaiShuai Zhang, Kan Wang   +4 more
openaire   +3 more sources

Hypothyroidism correlates with osteoporosis: potential involvement of lipid mediators

Frontiers in Medicine
BackgroundObservational studies have demonstrated a correlation between thyroid dysfunction and osteoporosis (OP); however, the underlying causality has yet to be fully elucidated.MethodsThe necessary dataset was sourced from public databases. Initially,
Pengyuan Leng, Ying Qiu, Mengxue Zhou, Yuhang Zhu, Na Yin, Mingming Zhou, Weili Wu, Min Liu   +7 more
doaj   +1 more source

Relationship Between Migraine and Alzheimer's Disease: A Study of Mendelian Randomization

Brain and Behavior
Background Given inconsistent evidence regarding the migraine‐Alzheimer's disease association, this Mendelian randomization (MR) study examines their potential causal relationship. Methods GWAS summary statistics for migraine and Alzheimer's disease were
Ran Bi, Weimin Zhao, Jiaoxuan Li, Songji Han, Haotian Qi, Jian Liu, Jinpu Wu, Shengxian Xu, Zhongda Sun, Zhenru Liu   +9 more
doaj   +1 more source

Leukemia and risk of stroke: a Mendelian randomization analysis

BMC Neurology
Observational studies suggest an association between leukemia and stroke, but causality remains unclear. Certain leukemia types may increase stroke risk, but variations exist in stroke and mortality rates across leukemia subtypes. This study employed Mendelian randomization (MR) to investigate links between leukemia subtypes and stroke.We conducted a ...
Xiaoyao Yi, Jingrui Zhu, Xiang Zhang, Ning Huang, Yuan Cheng   +4 more
openaire   +3 more sources

An investigation of the progression from Barrett's esophagus to adenocarcinoma [PDF]

, 2016
Barrett's esophagus is a metaplasia of the epithelium of the lower esophagus from a normal squamous appearance to a columnar appearance more typically found in the stomach. It is normally caused by prolonged gastric reflux. While Barrett's esophagus is
Palmese, Scott Joseph
core   +1 more source

Exploration of the causal relationship and mechanisms between serum albumin and venous thrombosis: a bidirectional mendelian randomization analysis and bioinformatics study

Thrombosis Journal
Background To explore the causal relationship between serum albumin and venous thromboembolism (VTE) comprises deep vein thrombosis (DVT) and its consequential condition, pulmonary embolism (PE), through Mendelian randomization (MR) design, seeking to ...
Xuemei Xia, Xin Tie, Maolin Hong, Wanhong Yin   +3 more
doaj   +1 more source

Causal association of plasminogen activators and their inhibitors with Alzheimer’s disease: a Mendelian randomization study

Archives of Medical Science
Introduction Alzheimer’s disease (AD) is the most common cause of dementia and contributes to a huge burden of disease worldwide. Observational studies have found that tissue plasminogen activator (t-PA) inhibits the development of AD, but little is ...
Xin Guo, Fangyu Gao, Baolong Pan, Feng Gao, Jingsi Zhang, Shanshan Wang, Qiao Niu   +6 more
doaj   +1 more source

Child height, health and human capital: evidence using genetic markers [PDF]

Height has long been recognised as associated with better outcomes: the question is whether this association is causal. We use children’s genetic variants as instrumental variables (IV) to deal with possible unobserved confounders and examine the effect ...
Carol Propper, Debbie A. Lawlor, Frank Windmeijer, George Davey Smith, Stephanie von Hinke Kessler Scholder   +4 more
core  

Immunophenotypic variations in syphilis: insights from Mendelian randomization analysis

Frontiers in Immunology
BackgroundInfection with Treponema pallidum instigates complex immune responses. Prior research has suggested that persistent Treponema pallidum infection can manipulate host immune responses and circumvent host defenses. However, the precise role of immune cells in Treponema pallidum infection across different stages remains a contentious issue ...
Qinghui Xie, Yijie Tang, Lingyun Shen, Dandan Yang, Jiaqin Zhang, Qingqiong Luo   +5 more
openaire   +3 more sources

Genetic Markers as Instrumental Variables [PDF]

The use of genetic markers as instrumental variables (IV) is receiving increasing attention from epidemiologists, economists, statisticians and social scientists.
Carol Propper, Debbie A. Lawlor, Frank Windmeijer, George Davey Smith, Stephanie von Hinke Kessler Scholder   +4 more
core