Results 91 to 100 of about 22,084,160 (163)

Sleep disturbances and heart failure: observational study and Mendelian randomization study

Introduction Sleep disturbances are prevalent among patients with heart failure (HF) and may trigger acute exacerbations of the condition. However, the causal relationship between sleep disturbances and HF remains uncertain.
Junwen Wang, Ziyi Sun, Xufeng Chen, Yuyang Ye, Yong Peng, Xinru Hu, Yi Zhong   +6 more
core   +1 more source

Periodontitis and osteoporosis: a two-sample Mendelian randomization analysis

Brazilian Journal of Medical and Biological Research
The incidences of periodontitis and osteoporosis are rising worldwide. Observational studies have shown that periodontitis is associated with increased risk of osteoporosis. We performed a Mendelian randomization (MR) study to genetically investigate the causality of periodontitis on osteoporosis.
Jiale Wu, Lihui Yao, Yuchen Liu, ShuaiShuai Zhang, Kan Wang   +4 more
openaire   +4 more sources

Association between type 1 diabetes mellitus and esophageal varices: a Mendelian randomization study

Introduction Esophageal varices (EV) are dilated submucosal veins in the distal esophagus connecting the portal vein to the systemic circulation. Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease associated with a variety of cardiovascular ...
Kai Feng, Jiang Yuan, Min Li, Yanhui Wei
core   +1 more source

Hypothyroidism correlates with osteoporosis: potential involvement of lipid mediators

Frontiers in Medicine
BackgroundObservational studies have demonstrated a correlation between thyroid dysfunction and osteoporosis (OP); however, the underlying causality has yet to be fully elucidated.MethodsThe necessary dataset was sourced from public databases. Initially,
Pengyuan Leng, Ying Qiu, Mengxue Zhou, Yuhang Zhu, Na Yin, Mingming Zhou, Weili Wu, Min Liu   +7 more
doaj   +1 more source

Relationship Between Migraine and Alzheimer's Disease: A Study of Mendelian Randomization

Brain and Behavior
Background Given inconsistent evidence regarding the migraine‐Alzheimer's disease association, this Mendelian randomization (MR) study examines their potential causal relationship. Methods GWAS summary statistics for migraine and Alzheimer's disease were
Ran Bi, Weimin Zhao, Jiaoxuan Li, Songji Han, Haotian Qi, Jian Liu, Jinpu Wu, Shengxian Xu, Zhongda Sun, Zhenru Liu   +9 more
doaj   +1 more source

Mendelian Randomization Analysis Identifies Causal Effects of Multi-Site Chronic Pain on Obstructive Sleep Apnea [PDF]

Zuxing Wang,1,* Lili Chen,1,* Ruishi Kang,2,* Zhuowei Li,2 Jiangang Fan,2 Yi Peng,3,* Yunqi He,4,5 Xiaolong Zhao2 1Sichuan Provincial Center for Mental Health, Sichuan Provincial People’s Hospital, School of Medicine, University of ...
Peng Y, Li Z, Kang R, He Y, Fan J, Chen L, Wang Z, Zhao X   +7 more
core  

An overview of this Mendelian randomization analysis.

IVW, inverse variance weighted; WM, weighted median; LOO analysis, leave-one-out analysis; MVMR, multivariable Mendelian randomization analysis; SNPs, single nucleotide polymorphisms.
Shaohua Ding (2534323), Luzhou Xu (14304938), Min Liang (363007), Xinyi Dai (1436044), Xiaohe Sun (7403538), Yanna Dai (18297648)   +5 more
core   +1 more source

Two-Sample Bidirectional Mendelian Randomization Analysis of the Causal Relationship Between Immune Cell Phenotypes and Systemic Lupus Erythematosus [PDF]

Weilu Niu, Jianwei Li, Huangchao Jia, Liyun Wang, Mengyue Xu, Xuewei Liu Department of Dermatology, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, People’s Republic of ChinaCorrespondence: Xuewei Liu, Email ...
Liu X, Li J, Xu M, Jia H, Niu W, Wang L
core  

DHEA and response to antidepressant treatment: A Mendelian Randomization analysis

Journal of Psychiatric Research
Treatment response is hard to predict and detailed mechanisms unknown. Lower levels of the dehydroepiandrosterone sulphate (DHEA(S)) - a precursor to testosterone and estrogen - have been associated to depression and to response to antidepressant treatment. Previous studies however may have been ridden by confounding and reverse causation.
Souza-Teodoro, LH, Davies, NM, Warren, HR, Andrade, LHSG, Carvalho, LA   +4 more
openaire   +4 more sources

Exploration of the causal relationship and mechanisms between serum albumin and venous thrombosis: a bidirectional mendelian randomization analysis and bioinformatics study

Thrombosis Journal
Background To explore the causal relationship between serum albumin and venous thromboembolism (VTE) comprises deep vein thrombosis (DVT) and its consequential condition, pulmonary embolism (PE), through Mendelian randomization (MR) design, seeking to ...
Xuemei Xia, Xin Tie, Maolin Hong, Wanhong Yin   +3 more
doaj   +1 more source