Results 71 to 80 of about 70,702 (197)

Instrumental Variables Estimation with Some Invalid Instruments and its Application to Mendelian Randomization

, 2014
Instrumental variables have been widely used for estimating the causal effect between exposure and outcome. Conventional estimation methods require complete knowledge about all the instruments' validity; a valid instrument must not have a direct effect ...
Cai, T. Tony, Kang, Hyunseung, Small, Dylan S., Zhang, Anru   +3 more
core   +2 more sources

Revealing the link between gut microbiota and brain tumor risk: a new perspective from Mendelian randomization

Frontiers in Cellular and Infection Microbiology
BackgroundRecent studies have shown that gut microbiota may be related to the occurrence of brain tumors, but direct evidence is lacking. This study used the Mendelian randomization study (MR) method to explore the potential causal link between gut ...
Jianyu Yang, Jietao Lu, Yuhan Dong, Youdong Wei, Michael Christian, Junmeng Huang, Haiyan Kuang, Du Cao   +7 more
doaj   +1 more source

Causal Mediation Analysis: A Summary‐Data Mendelian Randomization Approach

Statistics in Medicine
ABSTRACTSummary‐data Mendelian randomization (MR), a widely used approach in causal inference, has recently attracted attention for improving causal mediation analysis. Two existing methods corresponding to the difference method and product method of linear mediation analysis have been developed to perform MR‐based mediation analysis using the inverse ...
Shu‐Chin Lin, Sheng‐Hsuan Lin, Tian Ge, Chia‐Yen Chen, Yen‐Feng Lin   +4 more
openaire   +3 more sources

Addressing the credibility crisis in Mendelian randomization

BMC Medicine
Background Genome-wide association studies have enabled Mendelian randomization analyses to be performed at an industrial scale. Two-sample summary data Mendelian randomization analyses can be performed using publicly available data by anyone who has ...
Stephen Burgess, Benjamin Woolf, Amy M. Mason, Mika Ala-Korpela, Dipender Gill   +4 more
doaj   +1 more source

Associations of 35 Serum and Urine Biomarkers With Vascular Dementia—A Mendelian Randomization Study

Brain and Behavior
Background The relationship between serum and urine biomarkers with vascular dementia (VD) has been increasingly highlighted by observational studies. Yet, the causal nature underlying these associations remains elusive.
Xiaomin Zhu, Yanan Hu, Jieshuang Lin, Guifeng Zhuo, Yingrui Huang, Yulan Fu, Ying Zhang, Lin Wu, Wei Chen   +8 more
doaj   +1 more source

Neuroticism and posttraumatic stress disorder: A Mendelian randomization analysis

Brain and Behavior
AbstractObjectiveEpidemiological studies revealed an unestablished association between neuroticism and posttraumatic stress disorder (PTSD) and we conducted mendelian randomization (MR) analyses to examine whether neuroticism clusters of worry, depressed affect, and sensitivity to environmental stress and adversity (SESA) were involved in the ...
Zifan You, Shanshan Chen, Jinsong Tang
openaire   +3 more sources

Identifying atheroprotective fruits and vegetables by Mendelian Randomization analysis

Frontiers in Nutrition
BackgroundFruits and vegetables (FVs) are widely believed to mitigate the risk of atherosclerosis (AS). However, the causal relationships between specific FVs and AS risk factors remain unclear.MethodsThis study performed two-sample Mendelian Randomization (MR) analysis to infer the causality of the intake of 28 kinds of FVs with AS, as well as its ...
Shenji Yang, Zhikang Cao, Huidong Liu, Zhipeng Li, Shaoping Nie, Mingyong Xie   +5 more
openaire   +3 more sources

A bidirectional Mendelian randomization study integrating genome-wide association studies, expression quantitative trait locus, and methylation quantitative trait locus data revealed causal relationship between heavy cigarette dependence and Barrett’s esophagus

SAGE Open Medicine
Background: The association between smoking dependence and the risk of developing Barrett’s esophagus remains unclear. This study aimed to investigate whether a causal relationship exists between smoking dependence and Barrett’s esophagus, using ...
Zhou An, Meichun Zeng, Xianhua Wang
doaj   +1 more source

Assessment of relationships between epigenetic age acceleration and multiple sclerosis: a bidirectional mendelian randomization study

Epigenetics & Chromatin
Background The DNA methylation-based epigenetic clocks are increasingly recognized for their precision in predicting aging and its health implications. Although prior research has identified connections between accelerated epigenetic aging and multiple ...
Hongwei Liu, Hanqing Zhang, Zhaoxu Yin, Miaomiao Hou   +3 more
doaj   +1 more source

Mendelian randomization studies of risk and protective factors for osteoporosis: a systematic review and meta-analysis

Frontiers in Endocrinology
BackgroundMendelian randomization is believed to attenuate the biases inherent in observational studies, yet a meta-analysis of Mendelian randomization studies in osteoporosis has not been conducted thus far.
Wenhao Ji, Wenhao Ji, Bin Pan, Bin Pan, Xin Chen, Xin Chen, Zhaobai Lao, Zhaobai Lao, Wanlei Yang, Wanlei Yang, Yu Qian, Yu Qian   +11 more
doaj   +1 more source