Results 61 to 70 of about 70,702 (197)

Causal association between periodontitis and systemic diseases: a systematic review and meta-analysis of mendelian randomization studies

BMC Oral Health
Background Periodontitis has increasingly been recognized for its impact on systemic health. Mendelian Randomization (MR), an emerging causal inference method, effectively overcomes confounding biases in observational studies.
Yanghao Zhao, Churen Zhang, Xiaochi Chang, Jie Zhang, Chang Shu, Cheng Lin, Jianxia Hou   +6 more
doaj   +1 more source

Therapeutic targets for muscle weakness in older adults: proteome-wide Mendelian randomization and colocalization analyses

The Journal of Nutrition, Health and Aging
Background: Recent research highlights the importance of muscular strength as a key factor in physical fitness, a strong indicator of overall mortality risk, and a vital target for preventing chronic diseases.
Shuai-Kang Wang, Qi-Jun Wang, Xuan Zhao, Peng Wang, Xiang-Yu Li, Wei Wang, Shi-Bao Lu   +6 more
doaj   +1 more source

Using molecular genetic information to infer causality in observational data:Mendelian randomisation [PDF]

, 2015
Determining whether associations between lifestyle behaviours and health outcomes are causal is difficult in observational data. However, as genetic variants associated with these behaviours are discovered, this will provide opportunities for testing ...
Gage, Suzanne H., Munafò, Marcus R., Smith, George Davey, Taylor, Amy E., Ware, Jennifer J.   +4 more
core   +2 more sources

Immunocytes do not mediate food intake and the causal relationship with allergic rhinitis: a comprehensive Mendelian randomization

Frontiers in Nutrition
BackgroundObservational studies indicate a correlation between food intake and allergic rhinitis. The potential interplay between the immune system and allergic rhinitis might contribute causally to both food intake and allergic rhinitis, providing ...
Zhi-qiang Zhang, Jing-yang Li, You-wei Bao, Yu-Qi Song, Dong-xu Song, Cheng Wang, Xin-hua Zhu   +6 more
doaj   +1 more source

Power and sample size calculations for Mendelian randomization studies using one genetic instrument [PDF]

, 2013
postprin
Cowling, BJ, Freeman, G, Schooling, CM
core   +1 more source

Genetic Markers as Instrumental Variables:An Application to Child Fat Mass and Academic Achievement [PDF]

The use of genetic markers as instrumental variables (IV) is receiving increasing attention from economists. This paper examines the conditions that need to be met for genetic variants to be used as instruments.
Carol Propper, Debbie A. Lawlor, Frank Windmeijer, George Davey Smith, Stephanie von Hinke Kessler Scholder   +4 more
core   +3 more sources

Psychiatric genetics and the structure of psychopathology [PDF]

, 2018
For over a century, psychiatric disorders have been defined by expert opinion and clinical observation. The modern DSM has relied on a consensus of experts to define categorical syndromes based on clusters of symptoms and signs, and, to some extent ...
Andreassen, Ole A., Edenberg, Howard J., Faraone, Stephen V., Glatt, Stephen J., Kendler, Kenneth S., Smoller, Jordan W.   +5 more
core   +1 more source

Mendelian randomization analyses explore the relationship between cathepsins and lung cancer

Communications Biology, 2023
Lung cancer, a major contributor to cancer-related fatalities worldwide, involves a complex pathogenesis. Cathepsins, lysosomal cysteine proteases, play roles in various physiological and pathological processes, including tumorigenesis.
Jialin Li, Mingbo Tang, Xinliang Gao, Suyan Tian, Wei Liu   +4 more
doaj   +1 more source

Dietary factors and hypertension: A Mendelian randomization analysis

Food Science & Nutrition
AbstractThis research explores the causal link between dietary habits and hypertension through Mendelian randomization, providing distinct perspectives on the role of diet in addressing this worldwide health issue. Utilizing instrumental variables, we applied advanced statistical methods, including the weighted median, inverse variance weighted, and MR‐
Fanfan Li, Wenwen Yang, Shuo Sun, Wenhui He, Shangqing Xu, Biao Han, Minjie Ma   +6 more
openaire   +3 more sources

Maternal central obesity and birth size: a Mendelian randomization analysis [PDF]

Lipids in Health and Disease, 2018
Background: Observational studies have illustrated that maternal central obesity is associated with birth size,including of birth weight, birth length and head circumference, but the causal nature of these associations remains unclear. Objective: To test the causal effect of maternal central obesity on birth size and puberty height ...
Geng, T.-T., Huang, T.
openaire   +4 more sources