Results 41 to 50 of about 42,228 (267)

Evaluating the causal relationship of Levo-carnitine and risk of schizophrenia: a bidirectional two-sample mendelian randomization study

BMC Psychiatry
Background Schizophrenia is a debilitating mental disorder affecting about 1% of the global population, characterized by significant cognitive impairments and a strong hereditary component.
Haoyuan Qiu, Zicheng Zhong, Tianxing Wu, Haoran Hu, Meijuan Zhou, Zhijun Feng   +5 more
doaj   +1 more source

Single-cell transcriptomics and Mendelian randomization reveal LUCAT1’s role in right-sided colorectal cancer risk

Frontiers in Genetics
Background: Colorectal cancer (CRC) is a malignancy with high incidence and mortality rates globally, categorized into left-sided and right-sided CRC, each exhibiting significant differences in molecular characteristics, clinical manifestations, and ...
Zhihao Shang, Zhihao Shang, Songyang Xi, Songyang Xi, Songyang Xi, Yueyang Lai, Yueyang Lai, Haibo Cheng, Haibo Cheng   +8 more
doaj   +1 more source

Mendelian Randomization and Colocalization Analysis Reveal New Drug Targets for Oral Ulcer: A Mendelian Randomization Analysis

Health Science Reports
ABSTRACTBackground and AimsOral ulcer (OU) is a complex issue with limited effective treatments. This study uses multi‐omics data through summary Mendelian randomization (SMR) and colocalization analysis to identify specific gene associations with OU, aiming to find new therapeutic targets, repurpose existing drugs, and develop new treatment options ...
Xiaoyu Zhang, Hui Fan, Xiaoguang Zhang, Yanni Wang, Guozhong Chen   +4 more
openaire   +3 more sources

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Materials‐Guided Gene‐Ionizable Lipid Nanoparticles to Reverse Iron‐Associated Immune Resistance in Renal Cancer

Advanced Science, EarlyView.
ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin, Yulong Hong, Chengliang Yin, Wanyang Guo, Yaxuan Wang, Ruijiang Zeng, Ruilin Liu, Zexian Ding, Xinlin Liu, Shangqing Ren, Qiyang Liang, Yaohui Wang, Xu Zhang, João Conde, Yuan Li, Xin Ma, Liangyou Gu   +16 more
wiley   +1 more source

Diet and risk for hernia: a Mendelian randomization analysis

Frontiers in Nutrition
BackgroundThe relationship between dietary factors and hernias is currently unclear.MethodsThe UK Biobank was used to extract dietary factors that were used as exposures, including intake of alcohol, non-oily fish, beef, fresh fruit, oily fish, salad/raw vegetables, dried fruit, coffee, cereal, salt, tea, water, cooked vegetables, cheese, Lamb/mutton ...
Yanjiang Yang, Biao Han, Biao Han, Wenwen Yang   +3 more
openaire   +3 more sources

Transposase‐Assisted Donor Tethering Boosts Large‐Fragment HDR in Plants

Advanced Science, EarlyView.
A transposase‐assisted donor tethering strategy is developed to enhance homology‐directed repair in plants. By recruiting donor DNA to double‐strand breaks and synergizing with repair pathway reprogramming and transcription‐coupled donor design, this system markedly improves large‐fragment targeted insertion efficiency, providing a robust platform for ...
Sha Wei, Kai Zhang, Shuke Deng, Jinjie Chen, Xiaomei Huang, Jingfei Guo, Yuqing Wu, Yingjie Guo, Zhen Liang   +8 more
wiley   +1 more source

Causal association between periodontitis and systemic diseases: a systematic review and meta-analysis of mendelian randomization studies

BMC Oral Health
Background Periodontitis has increasingly been recognized for its impact on systemic health. Mendelian Randomization (MR), an emerging causal inference method, effectively overcomes confounding biases in observational studies.
Yanghao Zhao, Churen Zhang, Xiaochi Chang, Jie Zhang, Chang Shu, Cheng Lin, Jianxia Hou   +6 more
doaj   +1 more source

Therapeutic targets for muscle weakness in older adults: proteome-wide Mendelian randomization and colocalization analyses

The Journal of Nutrition, Health and Aging
Background: Recent research highlights the importance of muscular strength as a key factor in physical fitness, a strong indicator of overall mortality risk, and a vital target for preventing chronic diseases.
Shuai-Kang Wang, Qi-Jun Wang, Xuan Zhao, Peng Wang, Xiang-Yu Li, Wei Wang, Shi-Bao Lu   +6 more
doaj   +1 more source

Dietary factors and hypertension: A Mendelian randomization analysis

Food Science & Nutrition
AbstractThis research explores the causal link between dietary habits and hypertension through Mendelian randomization, providing distinct perspectives on the role of diet in addressing this worldwide health issue. Utilizing instrumental variables, we applied advanced statistical methods, including the weighted median, inverse variance weighted, and MR‐
Fanfan Li, Wenwen Yang, Shuo Sun, Wenhui He, Shangqing Xu, Biao Han, Minjie Ma   +6 more
openaire   +2 more sources