Results 21 to 30 of about 22,084,160 (163)

Unraveling the directional link between adiposity and inflammation: a bidirectional mendelian randomization approach [PDF]

, 2010
<b>Context</b>: Associations between adiposity and circulating inflammation markers are assumed to be causal, although the direction of the relationship has not been proven. <b>Objective</b>: The aim of the study was to explore
Jukema, J.W., Schaefer, E., Welsh, P., Westendorp, R.G.J., Jahn, S., Packard, C.J., Craen, A.J.M. de, de Craen, A.J.M., Sattar, N., Smith, G.D., Hingorani, A.D., Ford, I., Polisecki, E., Smith, G.Y., Robertson, M., Buckley, B.M., Macfarlane, P.W., Stott, D.J., Shepherd, J., Sattar, N.A.   +19 more
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Clustered environments and randomized genes: a fundamental distinction between conventional and genetic epidemiology. [PDF]

, 2007
BACKGROUND: In conventional epidemiology confounding of the exposure of interest with lifestyle or socioeconomic factors, and reverse causation whereby disease status influences exposure rather than vice versa, may invalidate causal interpretations of ...
Timpson, NJ, Timpson, Nic, Harbord, RM, Day, Ian, Timpson Nic, Lawlor, D, Smith George Davey, Smith, George Davey, Lawlor, Debbie A, Ebrahim, S, Harbord, Roger, Day Ian, Debbie A Lawlor, Nic Timpson, George Davey Smith, Ian Day, Shah Ebrahim, Roger Harbord, Lawlor Debbie A, Day, INM, Davey Smith, G, Ebrahim, Shah, Harbord Roger, Ebrahim Shah   +23 more
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Mendelian Randomization Analysis in Observational Epidemiology

Journal of Lipid and Atherosclerosis, 2019
Mendelian randomization (MR) in epidemiology is the use of genetic variants as instrumental variables (IVs) in non-experimental design to make causality of a modifiable exposure on an outcome or disease. It assesses the causal effect between risk factor and a clinical outcome.
Kwan Lee, Chi-Yeon Lim
openaire   +2 more sources

Blood lipids and prostate cancer: a Mendelian randomization analysis [PDF]

Cancer Medicine, 2016
AbstractGenetic risk scores were used as unconfounded instruments for specific lipid traits (Mendelian randomization) to assess whether circulating lipids causally influence prostate cancer risk. Data from 22,249 prostate cancer cases and 22,133 controls from 22 studies within the international PRACTICAL consortium were analyzed. Allele scores based on
Bull, Caroline J, Bonilla, Carolina, Holly, Jeff MP, Perks, Claire M, Davies, Neil, Haycock, Philip, Yu, Oriana Hoi Yun, Richards, J Brent, Eeles, Rosalind, Easton, Doug, Kote-Jarai, Zsofia, Amin Al Olama, Ali, Benlloch, Sara, Muir, Kenneth, Giles, Graham G, MacInnis, Robert J, Wiklund, Fredrik, Gronberg, Henrik, Haiman, Christopher A, Schleutker, Johanna, Nordestgaard, Børge G, Travis, Ruth C, Neal, David, Pashayan, Nora, Khaw, Kay-Tee, Stanford, Janet L, Blot, William J, Thibodeau, Stephen, Maier, Christiane, Kibel, Adam S, Cybulski, Cezary, Cannon-Albright, Lisa, Brenner, Hermann, Park, Jong, Kaneva, Radka, Batra, Jyotsna, Teixeira, Manuel R, Micheal, Agnieszka, Pandha, Hardev, Smith, George Davey, Lewis, Sarah J, Martin, Richard M, PRACTICAL Consortium   +42 more
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Mendelian randomization studies do not support a role for raised circulating triglyceride levels influencing type 2 diabetes, glucose levels, or insulin resistance. [PDF]

, 2011
OBJECTIVE: The causal nature of associations between circulating triglycerides, insulin resistance, and type 2 diabetes is unclear. We aimed to use Mendelian randomization to test the hypothesis that raised circulating triglyceride levels causally ...
Gaunt, TR, Weedon, Michael N., De Silva, N. Maneka G., Weedon, MN, Luan, Jian'an, Harbord, Roger M., Harbord, Roger M, Ward, Kirsten J, Luan, J, Smith, GD, N. Maneka G. De Silva, Morris, Andrew D, Morris, Andrew D., Gaunt, Tom, Ebrahim, S, Ward, KJ, Claudia Langenberg, Knight, Beatrice A., Donnelly, Louise A, Beverley Shields, McCarthy, Mark I, Shah Ebrahim, De Silva, N. Maneka G, Palmer, Colin N A, Timothy M. Frayling, Ebrahim, Shah, Tom Gaunt, Debbie A. Lawlor, Rachel M. Freathy, Sandhu, MS, Ebrahim, Shah B J, Sandhu, Manjinder S., Hattersley, Andrew T., Harbord, RM, Beatrice A. Knight, Hattersley, Andrew T, Smith, George Davey, Palmer, Colin N. A., Knight, Beatrice A, Lawlor, DA, Louise A. Donnelly, Knight, BA, Langenberg, C, Freathy, RM, Roger M. Harbord, Freathy, Rachel M, Andrew T. Hattersley, Weedon, Michael N, Hattersley, AT, Palmer, CN, McCarthy, MI, Michael N. Weedon, Palmer, Tom M, Sandhu, Manjinder S, Palmer, CNA, Shields, B, Lawlor, Debbie A, Andrew D. Morris, Langenberg, Claudia, Shields, Beverley, De Silva, N Maneka G, Ward, Kirsten J., Mark I. McCarthy, Palmer, Colin NA, Donnelly, LA, De Silva, NM, Davey Smith, G, Frayling, Timothy M., Wareham, N, Tom M. Palmer, Gaunt, T, Nicholas Wareham, Morris, AD, Jian'an Luan, Lawlor, D, Manjinder S. Sandhu, Lawlor, Debbie A., Wareham, Nicholas, McCarthy, Mark I., Freathy, Rachel M., Palmer, TM, Frayling, Timothy M, Kirsten J. Ward, Donnelly, Louise A., George Davey Smith, Palmer, Tom M., De Silva, N M G, Colin N.A. Palmer, Frayling, TM, Palmer, Colin N. A.; id_orcid   +89 more
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Survivor bias in Mendelian randomization analysis

Biostatistics, 2017
Mendelian randomization studies employ genotypes as experimental handles to infer the effect of genetically modified exposures (e.g. vitamin D exposure) on disease outcomes (e.g. mortality). The statistical analysis of these studies makes use of the standard instrumental variables framework.
Vansteelandt, Stijn, Dukes, Oliver, Martinussen, Torben   +2 more
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Homocysteine and small vessel stroke: A mendelian randomization analysis [PDF]

Annals of Neurology, 2019
ObjectiveTrials of B vitamin therapy to lower blood total homocysteine (tHcy) levels for prevention of stroke are inconclusive. Secondary analyses of trial data and epidemiological studies suggest that tHcy levels may be particularly associated with small vessel stroke (SVS).
Larsson, Susanna C., Traylor, Matthew, Markus, Hugh S.   +2 more
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Schematic representation of multivariable Mendelian randomization analysis.

, 2023
Schematic representation of multivariable Mendelian randomization analysis.
Jiting Zhang (7511933), Yang Sun (132532), Tiecheng Yu (10984662), Yue Li (102191)   +3 more
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Body Shape and Alzheimer’s Disease: A Mendelian Randomization Analysis [PDF]

Frontiers in Neuroscience, 2019
Obesity has been reported to be related to memory impairment and decline in cognitive function, possibly further leading to the development of Alzheimer's disease (AD). However, observational studies revealed both negative and positive associations between body shape (BS) and AD, thereby making it difficult to confirm causality due to residual ...
Yuchang Zhou, Xiubin Sun, Maigeng Zhou
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Dietary factors and risk for asthma: A Mendelian randomization analysis

Frontiers in Immunology, 2023
BackgroundPrevious research has found a link between dietary factors and asthma. However, few studies have analyzed the relationship between dietary factors and asthma using Mendelian randomization. Methods: The IEU Open GWAS project (https://gwas.mrcieu.ac.uk/) was the source of exposure and outcome datasets.
Wenwen Yang, Yanjiang Yang, Li He, Min Zhang, Shuo Sun, Feng Wang, Biao Han, Biao Han   +7 more
openaire   +3 more sources