Results 21 to 30 of about 23,652,556 (316)

Investigating the causal impact of gut microbiota on glioblastoma: a bidirectional Mendelian randomization study

BMC Genomics, 2023
Background Currently, the influence of microbiota on the occurrence, progression, and treatment of cancer is a topic of considerable research interest. Therefore, based on the theory of the gut-brain axis proved by previous studies, our objective was to ...
Chuan Zeng, Chaolong Zhang, Chunming He, Haimin Song   +3 more
doaj   +1 more source

Schematic representation of multivariable Mendelian randomization analysis.

, 2023
Schematic representation of multivariable Mendelian randomization analysis.
Jiting Zhang (7511933), Yang Sun (132532), Tiecheng Yu (10984662), Yue Li (102191)   +3 more
core   +1 more source

MendelianRandomization v0.5.0: updates to an R package for performing Mendelian randomization analyses using summarized data [version 2; peer review: 1 approved, 2 approved with reservations]

Wellcome Open Research, 2020
The MendelianRandomization package is a software package written for the R software environment that implements methods for Mendelian randomization based on summarized data. In this manuscript, we describe functions that have been added to the package or
Jim R. Broadbent, Christopher N. Foley, Andrew J. Grant, Amy M. Mason, James R. Staley, Stephen Burgess   +5 more
doaj   +1 more source

Unraveling the directional link between adiposity and inflammation: a bidirectional mendelian randomization approach [PDF]

, 2010
<b>Context</b>: Associations between adiposity and circulating inflammation markers are assumed to be causal, although the direction of the relationship has not been proven. <b>Objective</b>: The aim of the study was to explore
Jukema, J.W., Schaefer, E., Welsh, P., Westendorp, R.G.J., Jahn, S., Packard, C.J., Craen, A.J.M. de, de Craen, A.J.M., Sattar, N., Smith, G.D., Hingorani, A.D., Ford, I., Polisecki, E., Smith, G.Y., Robertson, M., Buckley, B.M., Macfarlane, P.W., Stott, D.J., Shepherd, J., Sattar, N.A.   +19 more
core   +1 more source

Effects of epigenetic age acceleration on kidney function: a Mendelian randomization study

Clinical Epigenetics, 2023
Background Previous studies have reported cross-sectional associations between measures of epigenetic age acceleration (EAA) and kidney function phenotypes. However, the temporal and potentially causal relationships between these variables remain unclear.
Yang Pan, Xiao Sun, Zhijie Huang, Ruiyuan Zhang, Changwei Li, Amanda H. Anderson, James P. Lash, Tanika N. Kelly   +7 more
doaj   +1 more source

Results of Mendelian randomization analysis of intelligence on PAS.

, 2023
Results of Mendelian randomization analysis of intelligence on PAS.
Tianmin Zhu (2206318), Furong Zhang (5690462), Yushan Shi (16440272), Zhangmeng Xu (16726372), Guorong Qiu (16726375), Duoduo Yu (16726378), Guogang Dai (9228115)   +6 more
core   +1 more source

Mendelian Randomization Analysis in Observational Epidemiology

Journal of Lipid and Atherosclerosis, 2019
Mendelian randomization (MR) in epidemiology is the use of genetic variants as instrumental variables (IVs) in non-experimental design to make causality of a modifiable exposure on an outcome or disease. It assesses the causal effect between risk factor and a clinical outcome.
Kwan Lee, Chi-Yeon Lim
openaire   +2 more sources

Blood lipids and prostate cancer: a Mendelian randomization analysis [PDF]

Cancer Medicine, 2016
AbstractGenetic risk scores were used as unconfounded instruments for specific lipid traits (Mendelian randomization) to assess whether circulating lipids causally influence prostate cancer risk. Data from 22,249 prostate cancer cases and 22,133 controls from 22 studies within the international PRACTICAL consortium were analyzed. Allele scores based on
Bull, Caroline J, Bonilla, Carolina, Holly, Jeff MP, Perks, Claire M, Davies, Neil, Haycock, Philip, Yu, Oriana Hoi Yun, Richards, J Brent, Eeles, Rosalind, Easton, Doug, Kote-Jarai, Zsofia, Amin Al Olama, Ali, Benlloch, Sara, Muir, Kenneth, Giles, Graham G, MacInnis, Robert J, Wiklund, Fredrik, Gronberg, Henrik, Haiman, Christopher A, Schleutker, Johanna, Nordestgaard, Børge G, Travis, Ruth C, Neal, David, Pashayan, Nora, Khaw, Kay-Tee, Stanford, Janet L, Blot, William J, Thibodeau, Stephen, Maier, Christiane, Kibel, Adam S, Cybulski, Cezary, Cannon-Albright, Lisa, Brenner, Hermann, Park, Jong, Kaneva, Radka, Batra, Jyotsna, Teixeira, Manuel R, Micheal, Agnieszka, Pandha, Hardev, Smith, George Davey, Lewis, Sarah J, Martin, Richard M, PRACTICAL Consortium   +42 more
openaire   +7 more sources

Graphical analysis for phenome-wide causal discovery in genotyped population-scale biobanks

Nature Communications, 2021
Mendelian randomization is a popular method to detect causal relationships between traits, but can be confounded by instances of horizontal pleiotropy. Here, the authors present a Mendelian randomization workflow which includes causal discovery analysis ...
David Amar, Nasa Sinnott-Armstrong, Euan A. Ashley, Manuel A. Rivas   +3 more
doaj   +1 more source

Results of Mendelian randomization analysis of PAS on intelligence.

, 2023
Results of Mendelian randomization analysis of PAS on intelligence.
Tianmin Zhu (2206318), Furong Zhang (5690462), Yushan Shi (16440272), Zhangmeng Xu (16726372), Guorong Qiu (16726375), Duoduo Yu (16726378), Guogang Dai (9228115)   +6 more
core   +1 more source