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Statistical methods for Mendelian randomization in genome-wide association studies: A review
Computational and Structural Biotechnology Journal, 2022 Genome-wide association studies have yielded thousands of associations for many common diseases and disease-related complex traits. The identified associations made it possible to identify the causal risk factors underlying diseases and investigate the ...
Frederick J. Boehm, Xiang Zhou
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Relationship between NAFLD and coronary artery disease: A Mendelian randomization study
Hepatology, EarlyView., 2022 Abstract Background and Aims There is an ongoing debate on whether NAFLD is an active contributor or an innocent bystander in the pathogenesis of coronary artery disease (CAD). The aim of the present study was to assess the causal relationship between NAFLD and CAD.
Zhewen Ren +4 more
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Overview of Mendelian Randomization Analysis
Journal of Rheumatic Diseases, 2020 The inference of causality from observational evidence may be problematic, as observational studies frequently include confounding factors or reverse causation for the identification of associations between exposure and outcome. Thus, in observational studies, the association between a risk factor and a disease of interest may not be causal.
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Causal effects of gut microbiome on hypertension: a Mendelian randomization study
Frontiers in Microbiology, 2023 BackgroundPrevious observational studies have shown that there is an important relationship between gut microbiota and hypertension, we performed a two-sample Mendelian randomization analysis to examine whether the gut microbiota is causally related to ...
Gang He +4 more
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Body Shape and Alzheimer’s Disease: A Mendelian Randomization Analysis [PDF]
Frontiers in Neuroscience, 2019 Obesity has been reported to be related to memory impairment and decline in cognitive function, possibly further leading to the development of Alzheimer's disease (AD). However, observational studies revealed both negative and positive associations between body shape (BS) and AD, thereby making it difficult to confirm causality due to residual ...
Yuchang Zhou, Xiubin Sun, Maigeng Zhou
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HeliyonThis study aimed to investigate whether there is a causal relationship between educational attainment and delirium at the genetic level using the Mendelian randomization method, and provide new evidence for studies in this field.
Xianjie Wan +9 more
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Frontiers in Genetics, 2023 Observational studies have suggested a positive association between gastroesophageal reflux disease and lung cancer, but due to the existence of confounders, it remains undetermined whether gastroesophageal reflux disease (GERD) has a causal association ...
Jing Yang +6 more
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MeRP: a high-throughput pipeline for Mendelian randomization analysis [PDF]
Bioinformatics, 2014 Abstract Summary: We present a Mendelian randomization (MR) pipeline (MeRP) to facilitate rapid, causal inference analysis through automating key steps in developing and analyzing genetic instruments obtained from publicly available data.
Peter Yin, Benjamin Voight
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Frontiers in Public HealthBackgroundThe association between air pollution, lung function, gastroesophageal reflux disease, and Non-alcoholic fatty liver disease (NAFLD) remains inconclusive. Previous studies were not convincing due to confounding factors and reverse causality. We
Runmin Cao +4 more
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Dietary factors and risk for asthma: A Mendelian randomization analysis
Frontiers in Immunology, 2023 BackgroundPrevious research has found a link between dietary factors and asthma. However, few studies have analyzed the relationship between dietary factors and asthma using Mendelian randomization. Methods: The IEU Open GWAS project (https://gwas.mrcieu.ac.uk/) was the source of exposure and outcome datasets.
Wenwen Yang +7 more
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