Results 11 to 20 of about 22,084,160 (163)

Addressing the credibility crisis in Mendelian randomization [PDF]

BMC Medicine
Background Genome-wide association studies have enabled Mendelian randomization analyses to be performed at an industrial scale. Two-sample summary data Mendelian randomization analyses can be performed using publicly available data by anyone who has ...
Stephen Burgess, Benjamin Woolf, Amy M. Mason, Mika Ala-Korpela, Dipender Gill   +4 more
doaj   +2 more sources

ACLY and CKD: A Mendelian Randomization Analysis

Kidney International Reports, 2022
Adenosine triphosphate-citrate lyase (ACLY) inhibition is a therapeutic strategy under investigation for atherosclerotic cardiovascular disease, nonalcoholic steatohepatitis, and metabolic syndrome. Mouse models suggest that ACLY inhibition could reduce inflammation and kidney fibrosis.
Mohammadi-Shemirani, P, Chong, M, Perrot, N, Pigeyre, M, Steinberg, GR, Paré, G, Krepinsky, JC, Lanktree, MB   +7 more
openaire   +3 more sources

Smoking and Heart Failure: A Mendelian Randomization and Mediation Analysis [PDF]

ESC Heart Failure, 2021
Abstract Aims We performed a Mendelian randomization (MR) study to elucidate the associations of ever smoking, lifelong smoking duration, and smoking cessation with heart failure (HF) risk. Methods and results We ...
Yunlong Lu, Zhouming Xu, Marios K. Georgakis, Zhen Wang, Hefeng Lin, Liangrong Zheng   +5 more
openaire   +3 more sources

Selenium and cancer risk: Wide‐angled Mendelian randomization analysis [PDF]

International Journal of Cancer, 2021
AbstractEvidence on the association between selenium and cancer risk is inconclusive. We conducted a Mendelian randomization study to examine the associations of selenium levels with 22 site‐specific cancers and any cancer. Single nucleotide polymorphisms (SNPs) strongly associated with toenail and blood (TAB) and blood selenium levels in mild linkage ...
Yuan, Shuai, Mason, Amy, Carter, Paul, Vithayathil, Mathew, Kar, Siddhartha, Burgess, Stephen, Larsson, Susanna C   +6 more
openaire   +5 more sources

Meta‐analysis andMendelianrandomization: A review [PDF]

Research Synthesis Methods, 2019
Mendelian randomization (MR) uses genetic variants as instrumental variables to infer whether a risk factor causally affects a health outcome. Meta‐analysis has been used historically in MR to combine results from separate epidemiological studies, with each study using a small but select group of genetic variants.
Bowden, J, Holmes, MV
openaire   +5 more sources

Mendelian randomization analysis with survival outcomes

Genetic Epidemiology, 2020
AbstractMendelian randomization (MR) is an established approach for assessing the causal effects of heritable exposures on outcomes. Outcomes of interest often include binary clinical endpoints, but may also include censored survival times. We explore the implications of both the Cox proportional hazard model and the additive hazard model in the ...
Cho, Youngjoo, Rau, Andrea, Reiner, Alex, Auer, Paul   +3 more
openaire   +4 more sources

Mendelian randomization and pleiotropy analysis

Quantitative Biology, 2021
BackgroundMendelian randomization (MR) analysis has become popular in inferring and estimating the causality of an exposure on an outcome due to the success of genome wide association studies. Many statistical approaches have been developed and each of these methods require specific assumptions.ResultsIn this article, we review the pros and cons of ...
openaire   +4 more sources

The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis [PDF]

PLoS Medicine, 2013
The association between adiposity and cardiometabolic traits is well known from epidemiological studies. Whilst the causal relationship is clear for some of these traits, for others it is not. We aimed to determine whether adiposity is causally related to various cardiometabolic traits using the Mendelian randomization approach.We used the adiposity ...
Fall, T, Hägg, S, Mägi, R, Ploner, A, Fischer, K, Horikoshi, M, Sarin, AP, Thorleifsson, G, Ladenvall, C, Kals, M, Kuningas, M, Draisma, HH, Ried, JS, van, Zuydam, NR, Huikari, V, Mangino, M, Sonestedt, E, Benyamin, B, Nelson, CP, Rivera, NV, Kristiansson, K, Shen, HY, Havulinna, AS, Dehghan, A, Donnelly, LA, Kaakinen, M, Nuotio, ML, Robertson, N, de Bruijn, RF, Ikram, MA, Amin, N, Balmforth, AJ, Braund, PS, Doney, AS, Döring, A, Elliott, P, Esko, T, Franco, OH, Gretarsdottir, S, Hartikainen, AL, Heikkilä, K, Herzig, KH, Holm, H, Hottenga, JJ, Hyppönen, E, Illig, T, Isaacs, A, Isomaa, B, Karssen, LC, Kettunen, J, Koenig, W, Kuulasmaa, K, Laatikainen, T, Laitinen, J, Lindgren, C, Lyssenko, V, Läärä, E, Rayner, NW, Männistö, S, Pouta, A, Rathmann, W, Rivadeneira, F, Ruokonen, A, Savolainen, MJ, Sijbrands, EJ, Small, KS, Smit, JH, Steinthorsdottir, V, Syvänen, AC, Taanila, A, Tobin, MD, Uitterlinden, AG, Willems, SM, Willemsen, G, Witteman, J, Perola, M, Evans, A, Ferrières, J, Virtamo, J, Kee, F, Tregouet, DA, Arveiler, D, Amouyel, P, Ferrario, MM, BRAMBILLA, PAOLO, Hall, AS, Heath, AC, Madden, PA, Martin, NG, Montgomery, GW, Whitfield, JB, Jula, A, Knekt, P, Oostra, B, van Duijn, CM, Penninx, BW, Davey Smith, G, Kaprio, J, Samani, NJ, Gieger, C, Peters, A, Wichmann, HE, Boomsma, DI, de Geus, EJ, Tuomi, T, Power, C, Hammond, CJ, Spector, TD, Lind, L, Orho Melander, M, Palmer, CN, Morris, AD, Groop, L, Järvelin, MR, Salomaa, V, Vartiainen, E, Hofman, A, Ripatti, S, Metspalu, A, Thorsteinsdottir, U, Stefansson, K, Pedersen, NL, McCarthy, MI, Ingelsson, E, Prokopenko, I.   +125 more
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Dairy Consumption and Body Mass Index Among Adults: Mendelian Randomization Analysis of 184802 Individuals from 25 Studies [PDF]

, 2018
BACKGROUND—Associations between dairy intake and body mass index (BMI) have been inconsistently observed in epidemiological studies, and the causal relationship remains ill defined.
Mendelian Randomization of Dairy Consumption Working Group
core   +3 more sources

Testing for non-linear causal effects using a binary genotype in a Mendelian randomization study : application to alcohol and cardiovascular traits [PDF]

, 2014
Background: Mendelian randomization studies have so far restricted attention to linear associations relating the genetic instrument to the exposure, and the exposure to the outcome.
Casas, Juan P., Leon, David A., Dudbridge, Frank, Whittaker, John C., Zuccolo, Luisa, Keating, Brendan J, Silverwood, Richard J., Holmes, Michael V, Smith, George Davey, Casas, Juan P, Silverwood, Richard J, Lawlor, Debbie A., Lawlor, Debbie A, Alcohol-ADH1B Consortium, Holmes, Michael V., Whittaker, John C, Leon, David A, Dale, Caroline E., Dale, Caroline E, Palmer, Tom M., Palmer, Tom, Keating, Brendan J.   +21 more
core   +1 more source