Results 11 to 20 of about 70,702 (197)

Blood lipids and prostate cancer: a Mendelian randomization analysis [PDF]

Cancer Medicine, 2016
Genetic risk scores were used as unconfounded instruments for specific lipid traits (Mendelian randomization) to assess whether circulating lipids causally influence prostate cancer risk. Data from 22,249 prostate cancer cases and 22,133 controls from 22
Amin Al Olama, A, Batra, J, Benlloch, S, Blot, WJ, Bonilla, C, Brenner, H, Bull, CJ, Cannon-Albright, L, Cybulski, C, Davies, N, Easton, D, Eeles, R, Giles, GG, Gronberg, H, Haiman, CA, Haycock, P, Holly, JM, Kaneva, R, Khaw, KT, Kibel, AS, Kote-Jarai, Z, Lewis, SJ, MacInnis, RJ, Maier, C, Martin, RM, Micheal, A, Muir, K, Neal, D, Nordestgaard, BG, Pandha, H, Park, J, Pashayan, N, Perks, CM, PRACTICAL consortium,, Richards, JB, Schleutker, J, Smith, GD, Stanford, JL, Teixeira, MR, Thibodeau, S, Travis, RC, Wiklund, F, Yu, OH   +42 more
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Multivariable Mendelian randomization: the use of pleiotropic genetic variants to estimate causal effects. [PDF]

American Journal of Epidemiology, 2015
A conventional Mendelian randomization analysis assesses the causal effect of a risk factor on an outcome by using genetic variants that are solely associated with the risk factor of interest as instrumental variables. However, in some cases, such as the
Burgess, Stephen, Thompson, Simon G
core   +4 more sources

Selenium and cancer risk: Wide‐angled Mendelian randomization analysis [PDF]

International Journal of Cancer, 2021
AbstractEvidence on the association between selenium and cancer risk is inconclusive. We conducted a Mendelian randomization study to examine the associations of selenium levels with 22 site‐specific cancers and any cancer. Single nucleotide polymorphisms (SNPs) strongly associated with toenail and blood (TAB) and blood selenium levels in mild linkage ...
Yuan, Shuai, Mason, Amy, Carter, Paul, Vithayathil, Mathew, Kar, Siddhartha, Burgess, Stephen, Larsson, Susanna C   +6 more
openaire   +5 more sources

ACLY and CKD: A Mendelian Randomization Analysis

Kidney International Reports, 2022
Adenosine triphosphate-citrate lyase (ACLY) inhibition is a therapeutic strategy under investigation for atherosclerotic cardiovascular disease, nonalcoholic steatohepatitis, and metabolic syndrome. Mouse models suggest that ACLY inhibition could reduce inflammation and kidney fibrosis.
Mohammadi-Shemirani, P, Chong, M, Perrot, N, Pigeyre, M, Steinberg, GR, Paré, G, Krepinsky, JC, Lanktree, MB   +7 more
openaire   +3 more sources

Mendelian randomization analysis with survival outcomes

Genetic Epidemiology, 2020
AbstractMendelian randomization (MR) is an established approach for assessing the causal effects of heritable exposures on outcomes. Outcomes of interest often include binary clinical endpoints, but may also include censored survival times. We explore the implications of both the Cox proportional hazard model and the additive hazard model in the ...
Cho, Youngjoo, Rau, Andrea, Reiner, Alex, Auer, Paul   +3 more
openaire   +4 more sources

Mendelian randomization and pleiotropy analysis

Quantitative Biology, 2021
BackgroundMendelian randomization (MR) analysis has become popular in inferring and estimating the causality of an exposure on an outcome due to the success of genome wide association studies. Many statistical approaches have been developed and each of these methods require specific assumptions.ResultsIn this article, we review the pros and cons of ...
openaire   +3 more sources

Meta‐analysis andMendelianrandomization: A review [PDF]

Research Synthesis Methods, 2019
Mendelian randomization (MR) uses genetic variants as instrumental variables to infer whether a risk factor causally affects a health outcome. Meta‐analysis has been used historically in MR to combine results from separate epidemiological studies, with each study using a small but select group of genetic variants.
Bowden, J, Holmes, MV
openaire   +5 more sources

Mendelian Randomization Analysis in Observational Epidemiology

Journal of Lipid and Atherosclerosis, 2019
Mendelian randomization (MR) in epidemiology is the use of genetic variants as instrumental variables (IVs) in non-experimental design to make causality of a modifiable exposure on an outcome or disease. It assesses the causal effect between risk factor and a clinical outcome.
Kwan Lee, Chi-Yeon Lim
openaire   +2 more sources

Survivor bias in Mendelian randomization analysis

Biostatistics, 2017
Mendelian randomization studies employ genotypes as experimental handles to infer the effect of genetically modified exposures (e.g. vitamin D exposure) on disease outcomes (e.g. mortality). The statistical analysis of these studies makes use of the standard instrumental variables framework.
Vansteelandt, Stijn, Dukes, Oliver, Martinussen, Torben   +2 more
openaire   +3 more sources

Homocysteine and small vessel stroke: A mendelian randomization analysis [PDF]

Annals of Neurology, 2019
ObjectiveTrials of B vitamin therapy to lower blood total homocysteine (tHcy) levels for prevention of stroke are inconclusive. Secondary analyses of trial data and epidemiological studies suggest that tHcy levels may be particularly associated with small vessel stroke (SVS).
Larsson, Susanna C., Traylor, Matthew, Markus, Hugh S.   +2 more
openaire   +3 more sources