Results 11 to 20 of about 42,228 (267)
BMC Genomics, 2023 Background Currently, the influence of microbiota on the occurrence, progression, and treatment of cancer is a topic of considerable research interest. Therefore, based on the theory of the gut-brain axis proved by previous studies, our objective was to ...
Chuan Zeng +3 more
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Wellcome Open Research, 2020 The MendelianRandomization package is a software package written for the R software environment that implements methods for Mendelian randomization based on summarized data. In this manuscript, we describe functions that have been added to the package or
Jim R. Broadbent +5 more
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Effects of epigenetic age acceleration on kidney function: a Mendelian randomization study
Clinical Epigenetics, 2023 Background Previous studies have reported cross-sectional associations between measures of epigenetic age acceleration (EAA) and kidney function phenotypes. However, the temporal and potentially causal relationships between these variables remain unclear.
Yang Pan +7 more
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Mendelian Randomization Analysis in Observational Epidemiology
Journal of Lipid and Atherosclerosis, 2019 Mendelian randomization (MR) in epidemiology is the use of genetic variants as instrumental variables (IVs) in non-experimental design to make causality of a modifiable exposure on an outcome or disease. It assesses the causal effect between risk factor and a clinical outcome.
Kwan Lee, Chi-Yeon Lim
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Blood lipids and prostate cancer: a Mendelian randomization analysis [PDF]
Cancer Medicine, 2016 AbstractGenetic risk scores were used as unconfounded instruments for specific lipid traits (Mendelian randomization) to assess whether circulating lipids causally influence prostate cancer risk. Data from 22,249 prostate cancer cases and 22,133 controls from 22 studies within the international PRACTICAL consortium were analyzed. Allele scores based on
Bull, Caroline J +42 more
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Graphical analysis for phenome-wide causal discovery in genotyped population-scale biobanks
Nature Communications, 2021 Mendelian randomization is a popular method to detect causal relationships between traits, but can be confounded by instances of horizontal pleiotropy. Here, the authors present a Mendelian randomization workflow which includes causal discovery analysis ...
David Amar +3 more
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Survivor bias in Mendelian randomization analysis
Biostatistics, 2017 Mendelian randomization studies employ genotypes as experimental handles to infer the effect of genetically modified exposures (e.g. vitamin D exposure) on disease outcomes (e.g. mortality). The statistical analysis of these studies makes use of the standard instrumental variables framework.
Vansteelandt, Stijn +2 more
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Homocysteine and small vessel stroke: A mendelian randomization analysis [PDF]
Annals of Neurology, 2019 ObjectiveTrials of B vitamin therapy to lower blood total homocysteine (tHcy) levels for prevention of stroke are inconclusive. Secondary analyses of trial data and epidemiological studies suggest that tHcy levels may be particularly associated with small vessel stroke (SVS).
Larsson, Susanna C. +2 more
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Can we apply the Mendelian randomization methodology without considering epigenetic effects?
Emerging Themes in Epidemiology, 2009 Introduction Instrumental variable (IV) methods have been used in econometrics for several decades now, but have only recently been introduced into the epidemiologic research frameworks.
Karmaus Wilfried +2 more
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Digital Health, 2023 Objective Inconsistent results were reported on the association of physical activity with ovarian cancer. However, given the limitations of confounders and inverse causation, the validity of the association remained unclear. Therefore, we conducted a two-
Jing Wang +3 more
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