Results 31 to 40 of about 70,702 (197)

Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase [PDF]

, 2015
Background Statins are first-line therapy for cardiovascular disease prevention, but their systemic effects across lipoprotein subclasses, fatty acids, and circulating metabolites remain incompletely characterized.
Ala-Korpela, M, Casas, J-P, Chaturvedi, N, Fatemifar, G, Hingorani, AD, Hughes, AD, Jarvelin, M-R, Kahonen, M, Kangas, AJ, Kettunen, J, Kivimaki, M, Lawlor, DA, Lehtimaki, T, Mantyselka, P, Perola, M, Raitakari, OT, Salomaa, V, Sattar, N, Smith, GD, Soininen, P, Tiainen, M, Tillin, T, Tynkkynen, T, Vanhala, M, Wang, Q, Wurtz, P   +25 more
core   +2 more sources

Associations Between Glycemic Traits and Colorectal Cancer: A Mendelian Randomization Analysis [PDF]

JNCI: Journal of the National Cancer Institute, 2022
AbstractBackgroundGlycemic traits—such as hyperinsulinemia, hyperglycemia, and type 2 diabetes—have been associated with higher colorectal cancer risk in observational studies; however, causality of these associations is uncertain. We used Mendelian randomization (MR) to estimate the causal effects of fasting insulin, 2-hour glucose, fasting glucose ...
Murphy, Neil, Song, Mingyang, Papadimitriou, Nikos, Carreras-Torres, Robert, Langenberg, Claudia, Martin, Richard M, Tsilidis, Konstantinos K, Barroso, Inês, Chen, Ji, Frayling, Timothy M, Bull, Caroline J, Vincent, Emma E, Cotterchio, Michelle, Gruber, Stephen B, Pai, Rish K, Newcomb, Polly A, Perez-Cornago, Aurora, Van Duijnhoven, Franzel JB, Van Guelpen, Bethany, Vodicka, Pavel, Wolk, Alicja, Wu, Anna H, Peters, Ulrike, Chan, Andrew T, Gunter, Marc J   +24 more
openaire   +7 more sources

Targeting inflammation to reduce cardiovascular disease risk: a realistic clinical prospect? [PDF]

, 2017
Data from basic science experiments is overwhelmingly supportive of the causal role of immune-inflammatory response(s) at the core of atherosclerosis, and therefore the theoretical potential to manipulate the inflammatory response to prevent ...
Abbas, Agca, Ait-Oufella, Albert, Alexander, Alexander, Alexander, Alexander, Andersen, Aziz, Babelova, Bellosta, Bevilacqua, Bhaskar, Blom, Boekholdt, Boekholdt, Bostrom, Brånén, Bulgarelli, Bulgarelli, Burke, Cai, Cannon, Casas, Collins, Cronstein, Dahlman-Ghozlan, Danesh, Davenport, Davey Smith, Davidson, DeOliveira, Devlin, Dinarello, Duewell, Duivenvoorden, Eisenhardt, Elango, Elhage, Ettehad, Flood, Fraser, Freigang, Fulgoni, Galkina, Galkina, Garlanda, Grassia, Grassia, Greenberg, Hansson, Hauer, Herder, Holmes, Hu, Huang, Huber, Interleukin 1 Genetics Consortium, Ivandic, Kalliolias, Kaptoge, Kimura, Kinlay, Kirii, Kleinman, Koltsova, Kureishi, Kwak, Lee, Leite, Leite, Lewington, Liao, Libby, Libby, Macritchie, Maddaluno, Maeda, Maffia, Makheja, Margaritis, McInnes, Menu, Micha, Mihaylova, Mira, Mohler, Montezano, Mulhaupt, Murad, Myasoedova, Myung, Nakata, Nicholls, O'Donoghue, Ogdie, Ohta, Pauling, Peters, Qiao, Quarck, Rajamäki, Rastogi, Reiss, Rezaie-Majd, Ridker, Ridker, Rincón, Robertson, Romano, Rosenson, Rosenson, Roubille, Ryan, Rössig, Saeed, Sage, Sarwar, Sattar, Scalia, Schett, Schieffer, Schuett, Serruys, Sever, Sever, Shah, Shaposhnik, Singh, Sirtori, Sniderman, Soedamah-Muthu, Solomon, Southan, Souverein, Sprague, Srikakulapu, Strober, Sukovich, Swerdlow, Swirski, Talmud, Tay, Teng, Thompson, Tits, Toedter, Turunen, Tzellos, Walker, Wang, Wang, Watson, Weintraub, Welsh, Welsh, Welsh, Welsh, Weng, Wensley, White, Wilensky, Willeit, Willis, Wong, Woodward, Xanthoulea, Ye, Ye, Yilmaz, Youssef, Zalewski, Zhao   +173 more
core   +2 more sources

MeRP: a high-throughput pipeline for Mendelian randomization analysis [PDF]

Bioinformatics, 2014
Abstract Summary: We present a Mendelian randomization (MR) pipeline (MeRP) to facilitate rapid, causal inference analysis through automating key steps in developing and analyzing genetic instruments obtained from publicly available data.
Peter, Yin, Benjamin F, Voight
openaire   +2 more sources

Relationship between lipids and sleep apnea: Mendelian randomization analysis

World Journal of Clinical Cases, 2022
Lipids increase the risk of sleep apnea; however, the causality between them is still inconclusive.To explore the causal relationship between serum lipids and sleep apnea using two-sample Mendelian randomization (MR) analysis.Single nucleotide polymorphism (SNP) data related to serum lipids were obtained from the Global Lipids Genetics Consortium study,
Zhang, Lian-Peng, Zhang, Xiao-Xia
openaire   +2 more sources

Causal effects of gut microbiome on hypertension: a Mendelian randomization study

Frontiers in Microbiology, 2023
BackgroundPrevious observational studies have shown that there is an important relationship between gut microbiota and hypertension, we performed a two-sample Mendelian randomization analysis to examine whether the gut microbiota is causally related to ...
Gang He, Yu Cao, Houzhao Wang, Houzhao Wang, Xiaoying Lv   +4 more
doaj   +1 more source

Estimating marginal healthcare costs using genetic variants as instrumental variables:Mendelian Randomization in economic evaluation [PDF]

, 2016
Accurate measurement of the marginal healthcare costs associated with different diseases and health conditions is important, especially for increasingly prevalent conditions such as obesity.
Davey Smith, George, Davies, Neil, Dixon, Padraig, Hollingworth, William, von Hinke, Stephanie   +4 more
core   +1 more source

Study on the causal relationship between educational attainment and delirium: A two-sample Mendelian randomization study

Heliyon
This study aimed to investigate whether there is a causal relationship between educational attainment and delirium at the genetic level using the Mendelian randomization method, and provide new evidence for studies in this field.
Xianjie Wan, Hui Yu, Mingyi Yang, Weikun Hou, Jiale Xie, Ke Xu, Yujie Ma, Rui Ma, Fan Wang, Peng Xu   +9 more
doaj   +1 more source

Theoretical impact of insecticide-impregnated school uniforms on dengue incidence in Thai children. [PDF]

, 2013
BACKGROUND: Children carry the main burden of morbidity and mortality caused by dengue. Children spend a considerable amount of their day at school; hence strategies that reduce human-mosquito contact to protect against the day-biting habits of Aedes ...
Amaku, Marcos, Coutinho, Francisco Antonio Bezerra, Kittayapong, Pattamaporn, Massad, Eduardo, Wilder-Smith, Annelies   +4 more
core   +2 more sources

Modifiable factors for migraine prophylaxis: A mendelian randomization analysis

Frontiers in Pharmacology, 2023
Objective: To examine the causal effect of potentially modifiable risk factors contributing to migraine pathogenesis.Methods: We performed Mendelian randomization analyses and acquired data from United Kingdom Biobank, FinnGen Biobank, and the MRC IEU OpenGWAS data infrastructure.
Hui Zheng, Yun-Zhou Shi, Jing-Tao Liang, Liang-Liang Lu, Min Chen   +4 more
openaire   +3 more sources