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Overview of Mendelian Randomization Analysis
Journal of Rheumatic Diseases, 2020 The inference of causality from observational evidence may be problematic, as observational studies frequently include confounding factors or reverse causation for the identification of associations between exposure and outcome. Thus, in observational studies, the association between a risk factor and a disease of interest may not be causal.openaire +2 more sourcesCausal relationship between air pollution, lung function, gastroesophageal reflux disease, and non-alcoholic fatty liver disease: univariate and multivariate Mendelian randomization study
Frontiers in Public HealthBackgroundThe association between air pollution, lung function, gastroesophageal reflux disease, and Non-alcoholic fatty liver disease (NAFLD) remains inconclusive. Previous studies were not convincing due to confounding factors and reverse causality. We Runmin Cao, Honghe Jiang, Yurun Zhang, Ying Guo, Weibin Zhang +4 moredoaj +1 more sourceStratification by Smoking Status Reveals an Association of CHRNA5-A3-B4 Genotype with Body Mass Index in Never Smokers [PDF]
, 2014 We previously used a single nucleotide polymorphism (SNP) in the CHRNA5-A3-B4 gene cluster associated with heaviness of smoking within smokers to confirm the causal effect of smoking in reducing body mass index (BMI) in a Mendelian randomisation analysis.Kumari, Meena, Paternoster, Lavinia, Postmus, Iris, Bjørngaard, Johan Håkon, Frayling Tim, Räikkönen, Katri, Munafò, Marcus R., Caroline Hayward (149856), Power Christine, Ahluwalia, TS, Sorensen, Thorkild I. A., Kirsten Ohm Kyvik (75576), Gabrielsen, Maiken Elvestad, Johan H Bjorngaard, Christiansen, Lene, Meg E. Fluharty (669886), Kyvik, KO, Smith, BH, Sandosh Padmanabhan (238533), Padmanabhan Sandosh, Wannamethee S. Goya, Morris Richard W., Kaprio, Jaakko, Cavadino, Alana, Peter H Whincup, Wannamethee, S. Goya, Whincup, PH, Martin Preisig, Vink, JM, Ford, I, Davey Smith George, Hällfors Jenni, Marioni, Riccardo R., Kyvik, Kirsten Ohm, Marques-Vidal, P, Marques-Vidal Pedro, Davey Smith, George, Cavadino, A, Skaaby, Tea, Vink, J.M., Lawlor, Debbie, Taylor Amy E., Ohm Kyvik, Kirsten; id_orcid, Wannamethee, S Goya, Marika Kaakinen, Taylor, A.E., Lavinia Paternoster (153181), Treur, J., Eriksson, Johan, Ahluwalia, T., Dale, C., Munafò, MR, Iris Postmus, Watt, G, Husemoen, Lise Lotte N., Treur, J.L., J. Wouter Jukema (127361), Jarvelin, Marjo-Riitta, Kisialiou Aliaksei, Nohr, EA, Davey Smith, G., Jukema, JW, Wong, A., Jari Lahti, Hällfors, J., Paternoster, L., Romundstad Pål R., Sattar, N, Smith, GD, Fergusson, D., Aarno Palotie (41342), Palotie, A, Ian Ford, Pål R Romundstad, Martin A Kennedy, Lavinia Paternoster, Dale Caroline, Kaprio Jaakko, Wannamethee, SG, Hyppönen, E., Tim Frayling, Eriksson, J, Linneberg Allan, Naveed Sattar, Ford, Ian, et al., Jenni Hällfors (669893), Dalgård, Christine, Postmus Iris, Fluharty, M.E., Tarunveer S. Ahluwalia (418885), Maiken E Gabrielsen, Linneberg, A., Husemoen, L., Palotie, A., Christine Dalgård, Bjørn Olav Åsvold (669889), Jarvelin Marjo-Riitta, Sorensen, TIA, Kisialiou, A., David M Fergusson, Husemoen, LL, Sørensen, Thorkild I. A., Bjorngaard, J.H., Bjorngaard, Johan H., Andrew Wong (256256), Treur, Jorien L, Ahluwalia, Tarunveer Singh, Alex McConnachie, Fergusson, DM, Ahluwalia, Tarunveer S, Lene Christiansen, Sørensen, Thorkild I.A., George Davey Smith, Sørensen, T.I.A., Hyppönen, Elina, Graham Watt (246706), Borodulin, Katja, Ohm Kyvik Kirsten, Ohm Kyvik, K., Campbell, A., Kuh, D., Kumari Meena, Andrew Wong, Borodulin Katja, Wong, A, Jari Lahti (149903), Husemoen, LLN, Fergusson, D, Frayling, Tim, Richard W Morris, Eriksson Johan, Asvold, B.O., Räikkönen Katri, Ellen A. Nohr (162402), Elina Hyppönen (163747), Männistö, Satu, McConnachie, A, Johan Eriksson, Alana Cavadino (448066), Smith, B.H., Martin Preisig (111534), Elina Hyppönen, Johan Eriksson (131534), Lene Christiansen (158189), Lahti, J., Marioni, R, Kaakinen Marika, Jukema, J.W., Fergusson David M., Whincup, P.H., Preisig, M, Gabrielsen, Maiken E., Pål R. Romundstad (420886), Power, C, Tyrrell, Jessica, Katja Borodulin, Archie Campbell (669891), Taylor, Amy E., McConnachie Alex, Kivimaki Mika, Smith, Blair H., Meg E Fluharty, Tea Skaaby (292885), Ben-Shlomo, Y., Preisig, Martin, Marjo-Riitta Jarvelin (110290), Marioni, R., Borodulin, K., Kumari, M., Jarvelin, MR, Hällfors, J, Sørensen, TI, Kennedy, M.A., Fluharty, ME, Fluharty, M., Alex McConnachie (104022), Vink Jacqueline M., Ben-Shlomo, Y, Nohr, Ellen A, Ian Ford (30666), Dalgård Christine, John Horwood (669895), Nohr Ellen A., Nohr, Ellen A., Smith, Blair H.; id_orcid, Munafo, M.R., Tarunveer S Ahluwalia, Satu Männistö, Taylor, Amy E, Romundstad, P.R., Marika Kaakinen (116620), Kisialiou, A, Marcus R Munafò, Männistö, S, Vink, Jacqueline M, Kennedy Martin A., Kivimaki, M., Tyrrell, J, Horwood, J., Postmus, I, Bjorngaard, Johan H, Hayward, C, Asvold, Bjørn Olav, Sørensen, Thorkild I A, Amy E. Taylor (111604), Horwood, John, Linneberg, A, Lawlor, D, Aliaksei Kisialiou (267828), Jessica Tyrrell (482364), Debbie Lawlor, Kivimaki, M, Jacqueline M Vink, Ohm Kyvik, K, Christine Power, Whincup, Peter H., Marjo-Riitta Jarvelin, Munafò Marcus R., Asvold, Bjorn Olav, Watt, G., Hyppönen Elina, Marioni, Riccardo, Ford Ian, Sørensen Thorkild I. A., Romundstad, PR, Yoav Ben-Shlomo, Watt, Graham, Åsvold Bjørn Olav, Kumari, M, Pedro Marques-Vidal, Jaakko Kaprio (43154), Frayling, T, Fergusson, D.M., Ellen A Nohr, Palotie Aarno, Satu Männistö (201550), Kaakinen, M, Maiken E. Gabrielsen (669890), Sorensen, T.I.A., Pedro Marques-Vidal (58558), Allan Linneberg, Martin A. Kennedy (278135), Katja Borodulin (669897), Sørensen, Thorkild IA, Jessica Tyrrell, Kaakinen, Marika, Bjorngaard, J., Hayward, C., Åsvold, BO, Kivimaki, Mika, Jukema, J. Wouter, Christiansen, L., Jorien L Treur, Jukema, J Wouter, Fluharty, Meg E, Sattar Naveed, Marques-Vidal, Pedro, Power, Christine, Horwood John, Bjorngaard, JH, Archie Campbell, Kuh, Diana, Campbell, A, Naveed Sattar (8785), Dorret I Boomsma, Gonneke Willemsen (75573), Räikkönen, K, Blair H. Smith (625812), Whincup, Peter H, J Wouter Jukema, Sattar, Naveed, Diana Kuh, Palotie, Aarno, Kaprio, J., Christine Power (448073), Dorret I. Boomsma (109746), Dale, C, Kirsten Ohm Kyvik, Thorkild I. A. Sørensen (37671), Ahluwalia, Tarun Veer Singh, Mika Kivimaki (2222011), S Goya Wannamethee, Kuh Diana, Cavadino Alana, George Davey Smith (82619), Smith, G.D., Husemoen, Lise Lotte N, Hyppönen, E, Nohr, Ellen A; id_orcid, Frayling, T., Dale, Caroline, Kennedy, MA, Boomsma Dorret I., Eriksson, J., Morris, R., Richard W. Morris (351802), Power, C., Lahti, Jari, Åsvold, B., Tyrrell Jessica, Lawlor, D., Willemsen, Gonneke, Jarvelin, M-R, Campbell, Archie, Sorensen, Thorkild, Borodulin, K, Dalgård, C, Jenni Hällfors, Padmanabhan, Sandosh, Katri Räikkönen (149957), Männistö Satu, Lise Lotte N. Husemoen (244333), Fluharty Meg E., Morris, RW, Horwood, L.J., Marioni Riccardo, Kennedy, Martin A., Blair H Smith, Gonneke Willemsen, Romundstad, Pål R., Ahluwalia Tarunveer S., Dalgård, Christine; id_orcid, Ohm Kyvik, Kirsten, Skaaby Tea, Marques-Vidal, P., Davey Smith, G, Kaprio, J, Jukema J. Wouter, Treur, Jorien L., Kuh, D, Watt Graham, Willemsen, G, Caroline Hayward, Boomsma, D.I.; id_orcid, Allan Linneberg (139773), Tea Skaaby, Männistö, S., Morris, R.W., Taylor, AE, Marcus R. Munafò (171830), Boomsma, Dorret I, Fergusson, David M, Riccardo Marioni (669892), Christiansen, L, Cavadino, A., Caroline Dale, Campbell Archie, Lahti, J, Ahluwalia, Tarunveer S., Willemsen, G.; id_orcid, Morris, Richard W., Bjørn Olav Åsvold, Caroline Dale (448065), David M. Fergusson (278134), Munafò, Marcus R, Meena Kumari (95278), Romundstad, Pål R, Graham Watt, Hayward Caroline, Taylor, A., Johan H. Bjorngaard (669888), Postmus, I., Smith, George Davey, Bjorngaard Johan H., Treur Jorien L., Paternoster Lavinia, Nohr, E.A., Boomsma, Dorret I., Husemoen, L.L., Ben-Shlomo, Yoav, Hayward, Caroline, Husemoen, L.L.N., Kaakinen, M., Smith Blair H., Sattar, N., Smith, Blair H, Lawlor, Debbie A, Ford, I., Linneberg, Allan, Romundstad, Pål Richard, Willemsen Gonneke, Alana Cavadino, S. Goya Wannamethee (669283), Lahti Jari, Wong Andrew, Vink, Jacqueline M., Peter H. Whincup (168892), Debbie Lawlor (669896), Kennedy, Martin A, Aarno Palotie, Boomsma, DI, Yoav Ben-Shlomo (95286), Lawlor Debbie, Katri Räikkönen, Padmanabhan, S, Gabrielsen Maiken E., Preisig Martin, Riccardo Marioni, Lise Lotte N Husemoen, Christine Dalgård (323021), Morris, Richard W, Mika Kivimaki, Järvelin, M.R., Treur, JL, Fluharty, Meg E., Amy E Taylor, Wannamethee, S.G., Meena Kumari, Räikkönen, K., Willemsen, G., Preisig, M., Husemoen Lise Lotte N., McConnachie, A., Jacqueline M. Vink (109713), Aliaksei Kisialiou, Padmanabhan, S., Hällfors, Jenni, Ahluwalia, T.S., Tim Frayling (157530), Horwood, J, Jaakko Kaprio, Gabrielsen, Maiken E, McConnachie, Alex, Boomsma, D.I., Fluharty, Meg, Fergusson, David M., Thorkild I A Sørensen, Frayling, T.M., Skaaby, T, Kisialiou, Aliaksei, Gabrielsen, M., Sørensen, T.I., Iris Postmus (312601), Skaaby, T., Christiansen Lene, Kyvik, K.O., Whincup Peter H., Jorien L. Treur (669894), Dalgard, C., Tyrrell, J., Sandosh Padmanabhan, Hayward, Caroline; id_orcid, Gabrielsen, ME, John Horwood, Wong, Andrew, Paternoster, L, Ben-Shlomo Yoav, Gabrielsen, M.E., Diana Kuh (188923) +449 morecore +1 more sourceDiabetes and Risk of Arterial Stiffness: A Mendelian Randomization Analysis [PDF]
Diabetes, 2016 We aimed to explore the causal association between type 2 diabetes (T2D) and increased arterial stiffness. We performed a Mendelian randomization (MR) analysis in 11,385 participants from a well-defined community study in Shanghai during 2011–2013. We genotyped 34 T2D-associated common variants identified in East Asians and created a genetic risk score Min, Xu, Ya, Huang, Lan, Xie, Kui, Peng, Lin, Ding, Lin, Lin, Po, Wang, Mingli, Hao, Yuhong, Chen, Yimin, Sun, Lu, Qi, Weiqing, Wang, Guang, Ning, Yufang, Bi +13 moreopenaire +2 more sources
