Results 51 to 60 of about 70,702 (197)

Joint analysis of SNP and gene expression data in genetic association studies of complex diseases [PDF]

, 2014
Genetic association studies have been a popular approach for assessing the association between common Single Nucleotide Polymorphisms (SNPs) and complex diseases.
Huang, Yen-Tsung, Lin, Xihong, VanderWeele, Tyler J.   +2 more
core   +1 more source

Network Mendelian randomization: using genetic variants as instrumental variables to investigate mediation in causal pathways [PDF]

, 2015
Background: Mendelian randomization uses genetic variants, assumed to be instrumental variables for a particular exposure, to estimate the causal effect of that exposure on an outcome.
Burgess, Stephen, Butterworth, Adam S., Daniel, Rhian, the EPIC-InterAct Consortium,, Thompson, Simon G.   +4 more
core   +1 more source

Evaluating the causal relationship of Levo-carnitine and risk of schizophrenia: a bidirectional two-sample mendelian randomization study

BMC Psychiatry
Background Schizophrenia is a debilitating mental disorder affecting about 1% of the global population, characterized by significant cognitive impairments and a strong hereditary component.
Haoyuan Qiu, Zicheng Zhong, Tianxing Wu, Haoran Hu, Meijuan Zhou, Zhijun Feng   +5 more
doaj   +1 more source

The causal relationship between obesity and IgA nephropathy: a Mendelian randomization study

Linchuang shenzangbing zazhi
ObjectiveTo explore the potential causal relationship between obesity and IgA nephropathy through Mendelian randomization. MethodsSummary-level data from genome-wide association studies of obesity-related shapes (body mass index, percentage body fat ...
Peng-tao Dong, Zheng Wang, Xiao-yu Li, Qing Zhang   +3 more
doaj   +1 more source

Mendelian randomization with a binary exposure variable: interpretation and presentation of causal estimates [PDF]

, 2018
Mendelian randomization uses genetic variants to make causal inferences about a modifiable exposure. Subject to a genetic variant satisfying the instrumental variable assumptions, an association between the variant and outcome implies a causal effect of ...
Burgess, S. (Stephen), Labrecque, J.A. (Jeremy A.)   +1 more
core   +2 more sources

Mendelian Randomization and Colocalization Analysis Reveal New Drug Targets for Oral Ulcer: A Mendelian Randomization Analysis

Health Science Reports
ABSTRACTBackground and AimsOral ulcer (OU) is a complex issue with limited effective treatments. This study uses multi‐omics data through summary Mendelian randomization (SMR) and colocalization analysis to identify specific gene associations with OU, aiming to find new therapeutic targets, repurpose existing drugs, and develop new treatment options ...
Xiaoyu Zhang, Hui Fan, Xiaoguang Zhang, Yanni Wang, Guozhong Chen   +4 more
openaire   +3 more sources

Does ankylosing spondylitis exert a bidirectional influence on hypertension? A two-sample Mendelian randomization study

SAGE Open Medicine
Objective: Previous observational studies reported that ankylosing spondylitis is closely related to hypertension. However, it is still controversial whether the association between ankylosing spondylitis and hypertension is causal.
Weiran Hu, Kai Zhang, Guang Yang, Haoxu Wang, Yanzheng Gao   +4 more
doaj   +1 more source

Single-cell transcriptomics and Mendelian randomization reveal LUCAT1’s role in right-sided colorectal cancer risk

Frontiers in Genetics
Background: Colorectal cancer (CRC) is a malignancy with high incidence and mortality rates globally, categorized into left-sided and right-sided CRC, each exhibiting significant differences in molecular characteristics, clinical manifestations, and ...
Zhihao Shang, Zhihao Shang, Songyang Xi, Songyang Xi, Songyang Xi, Yueyang Lai, Yueyang Lai, Haibo Cheng, Haibo Cheng   +8 more
doaj   +1 more source

Blood lipids influence DNA methylation in circulating cells [PDF]

, 2016
Background: Cells can be primed by external stimuli to obtain a long-term epigenetic memory. We hypothesize that long-term exposure to elevated blood lipids can prime circulating immune cells through changes in DNA methylation, a process that may ...
't Hoen, P.A.C. (Peter A.C.), Berg, L.H. (Leonard) van den, Bonder, M.J. (Marc), Boomsma, D.I. (Dorret), Deelen, J. (Joris), Dekkers, K.F. (Koen F.), Dongen, J. (Jenny) van, Duijn, C.M. (Cornelia) van, Franke, L. (Lude), Greevenbroek, M.M. van, Heemst, D. (Diana) van, Heijmans, B.T. (Bastiaan), Hofman, A. (Albert), Hottenga, J.J. (Jouke Jan), Iterson, M. (Maarten) van, Jansen, R., Jukema, J.W. (Jan Wouter), Kallen, C.J. van der, Mei, S. (Shan), Meurs, J.B.J. (Joyce) van, Moed, H. (Heleen), Schalkwijk, C.G. (Casper), Slagboom, P.E. (Eline), Slieker, R. (Roderick), Stehouwer, C.D. (Coen), Tigchelaar, E.F. (Ettje F.), Uitterlinden, A.G. (André), Van Galen, M. (Michiel), Veldink, J.H. (Jan), Wijmenga, C. (Cisca), Willemsen, G.A.H.M. (Gonneke), Zhernakova, A. (Alexandra), Zhernakova, A. (Alexandra), Zwet, E.W. (Erik) van   +33 more
core   +1 more source

Smoking, alcohol consumption, and 24 gastrointestinal diseases: Mendelian randomization analysis

eLife, 2023
Background: Whether the positive associations of smoking and alcohol consumption with gastrointestinal diseases are causal is uncertain. We conducted this Mendelian randomization (MR) to comprehensively examine associations of smoking and alcohol consumption with common gastrointestinal diseases.
Yuan, Shuai, Chen, Jie, Ruan, Xixian, Sun, Yuhao, Zhang, Ke, Wang, Xiaoyan, Li, Xue, Gill, Dipender, Burgess, Stephen, Giovannucci, Edward, Larsson, Susanna C   +10 more
openaire   +4 more sources