Results 81 to 90 of about 70,702 (197)

Inflammation and keratoconus: A comprehensive bidirectional Mendelian randomization analysis

Medicine
An increasing body of evidence supports the involvement of inflammation and immune responses in the occurrence and development of keratoconus (KC). However, the causal relationship between inflammatory factors and KC remains unclear. We employed a 2-way Mendelian randomization (MR) approach to investigate the interaction between KC and inflammatory ...
Zhang, Xueyan, Cui, Fenghua, Wang, Qiaoling, Zhang, Chenming   +3 more
openaire   +2 more sources

Can Omega-3 prevent the accidence of stroke: a mendelian randomization study

Hereditas
Background The lipid-lowering effects of Omega-3 fatty acids have been widely reported, yet their impact on ischemic stroke remains controversial. Reports on the protective effects of unsaturated fatty acids, such as Omega-6 and Omega-7, as well as ...
Chongcheng Xi, Jie Zhang, Haihui Liu, Sian Tao, Ying Xie, Jibin Liu, Changqing Tong, Dong Tian, Hua Ye, Xiaobo Zhang   +9 more
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Mendelian randomization analysis

Mendelian randomization ...
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Mendelian randomization analysis of female reproductive factors on osteoarthritis

Medicine
Epidemiology shows women have a higher incidence of osteoarthritis (OA) than men. However, there is not enough evidence to suggest a direct correlation between female reproductive factors and OA. Therefore, this study will employ Mendelian randomization (MR) analysis to investigate whether there is a causal relationship between the 2. This study used a
Pang, Liang, Wu, Kai, Su, Pingping, Liao, Zhicheng, Lv, Cunxian   +4 more
openaire   +2 more sources

Genetically predicted ankylosing spondylitis increases the risk of heart failure: a Mendelian randomization study

Frontiers in Cardiovascular Medicine
BackgroundObservational studies have indicated a potential association between ankylosing spondylitis and elevated cardiovascular disease (CVD) risk. However, it remains uncertain whether this association reflects a causal association.
Chennan Liu, Chennan Liu, Laicheng Wang, Mei Lin, Mei Lin, Jing You, Jing You, Xuan Zheng, Xuan Zheng, Ailing Wang, Ailing Wang, Yunchai Lin, Yunchai Lin, Feng Peng, Feng Peng, Dan Hu   +15 more
doaj   +1 more source

Diet and risk for hernia: a Mendelian randomization analysis

Frontiers in Nutrition
BackgroundThe relationship between dietary factors and hernias is currently unclear.MethodsThe UK Biobank was used to extract dietary factors that were used as exposures, including intake of alcohol, non-oily fish, beef, fresh fruit, oily fish, salad/raw vegetables, dried fruit, coffee, cereal, salt, tea, water, cooked vegetables, cheese, Lamb/mutton ...
Yanjiang Yang, Biao Han, Biao Han, Wenwen Yang   +3 more
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Causality between immunocytes and polymyositis: A Mendelian randomization analysis

Medicine
Polymyositis is a prominent subgroup of idiopathic inflammatory myopathy, considered to have an autoimmune etiology. However, research exploring the condition between immunocytes and polymyositis remains limited, indicating the need for further investigation to unravel these intricate associations. We employed bidirectional Mendelian randomization (MR)
Ni Yang, Chang Li, Ruhui Liu, Xianghua Qi, Xing Qian   +4 more
openaire   +2 more sources

Causal and mediating effects of lipid and facial aging: association study integrating GWAS, eQTL, mQTL, and pQTL data

Lipids in Health and Disease
Background Increasing evidence suggests a potential causal association between lipid levels and facial aging. The aim of this study was to investigate the relationship between levels of specific lipids and facial aging via Mendelian randomization methods.
Mingjian Zhao, Zhanchen He, Lukuan Liu, Yichen Wang, LinQi Gao, Yuxuan Shang, Mengru Zhu   +6 more
doaj   +1 more source

Proteome‐Wide Mendelian Randomization Identifies Therapeutic Targets for Abdominal Aortic Aneurysm

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The proteome is a key source of therapeutic targets. We conducted a comprehensive Mendelian randomization analysis across the proteome to identify potential protein markers and therapeutic targets for abdominal aortic aneurysm (AAA).
Ka Zhang, Yuan Liu, Aiqin Mao, Changzhu Li, Li Geng, Hao Kan   +5 more
doaj   +1 more source

Gut microbiota, blood metabolites, & pan-cancer: a bidirectional Mendelian randomization & mediation analysis

AMB Express
We propose using Mendelian randomization analysis on GWAS data and MetaboAnalyst to model gut microbiota, metabolic pathways, blood metabolites, and cancer risk. We examined 473 gut microbiota, 205 pathways, 1400 metabolites, and 8 cancers.
Biqing Luan, Yang Yang, Qizhi Yang, Zhiqiang Li, Zhihui Xu, Yaqin Chen, Meiting Wang, Wenlin Chen, Fei Ge   +8 more
doaj   +1 more source