Results 81 to 90 of about 42,228 (267)

Multi‐Cohort Analysis Reveals Genetic Predispositions to Clonal Hematopoiesis as Mutation‐Specific Risk Factors for Stroke

Advanced Genetics, Volume 6, Issue 1, March 2025.
This study comprehensively evaluated the differential effect of clonal hematopoiesis (CH) mutations on the risk of various stroke subtypes and functional recovery. It shows that TET2 is associated with small vessel stroke possibly via a pro‐inflammatory pathway. Abstract Recent observational studies have found an association between Clonal Hematopoesis
Shuyang Lin, Yang E. Li, Yan Wang
wiley   +1 more source

Can Omega-3 prevent the accidence of stroke: a mendelian randomization study

Hereditas
Background The lipid-lowering effects of Omega-3 fatty acids have been widely reported, yet their impact on ischemic stroke remains controversial. Reports on the protective effects of unsaturated fatty acids, such as Omega-6 and Omega-7, as well as ...
Chongcheng Xi, Jie Zhang, Haihui Liu, Sian Tao, Ying Xie, Jibin Liu, Changqing Tong, Dong Tian, Hua Ye, Xiaobo Zhang   +9 more
doaj   +1 more source

Research progress of Mendelian randomization analysis for glaucoma etiology

International Journal of Ophthalmology
In recent years, Mendelian randomization (MR) has been increasingly utilized, leveraging genetic variants as instrumental variables. This approach significantly mitigates confounder effects and reverse causation, precisely clarifying the causal links between exposures and outcomes.
Jiao-Man Wang, Yin-Wei Song, Jing-Jing Su, Li-Cheng Fu, Di Gong, Ping Guo, Wei-Hua Yang   +6 more
openaire   +3 more sources

Crosstalk Between Parkinson's Disease and Colorectal Cancer: Genetic Mechanisms, Gut Microbiota, and Therapeutic Insights

Health Care Science, EarlyView.
This review elucidates the crosstalk between Parkinson's disease and colorectal cancer, driven by shared genetics (PRKN, PINK1, DJ‐1) involving oxidative stress, cell cycle regulation, and inflammation. It identifies the gut microbiota—via functional amyloids and short‐chain fatty acids (SCFAs)—as a mechanistic bridge, offering insights for dual ...
Jiacheng Ying, Zhengyuan Fang, Cheng Zhang, Xu Liu, Jianzhi Cui, Zezhi Li, Jiayin Tang   +6 more
wiley   +1 more source

Genetically predicted ankylosing spondylitis increases the risk of heart failure: a Mendelian randomization study

Frontiers in Cardiovascular Medicine
BackgroundObservational studies have indicated a potential association between ankylosing spondylitis and elevated cardiovascular disease (CVD) risk. However, it remains uncertain whether this association reflects a causal association.
Chennan Liu, Chennan Liu, Laicheng Wang, Mei Lin, Mei Lin, Jing You, Jing You, Xuan Zheng, Xuan Zheng, Ailing Wang, Ailing Wang, Yunchai Lin, Yunchai Lin, Feng Peng, Feng Peng, Dan Hu   +15 more
doaj   +1 more source

Plasma proteins and rheumatoid arthritis: A Mendelian randomization analysis

Medicine
Rheumatoid arthritis (RA) is a chronic, progressive inflammatory systemic autoimmune disease with incompletely understood etiology, causing substantial global disease burden. This study aimed to identify plasma proteins associated with RA using Mendelian randomization (MR) of large-scale plasma proteomics, providing potential ...
Chuan Lu, Xiao-Xiao Huang, Xin Lu, Ming Huang, Jianwen Xu   +4 more
openaire   +2 more sources

The causal relationship between systemic lupus erythematosus and juvenile myoclonic epilepsy: A Mendelian randomization study and mediation analysis

Ibrain, Volume 11, Issue 1, Page 98-105, Spring 2025.
Mendelian randomization (MR) studies were conducted using the inverse‐variance weighted (IVW) method, MR‐Egger and weighted median on juvenile myoclonic epilepsy (JME), and systemic lupus erythematosus (SLE) data from the Integrative Epidemiology Unit (IEU) Open genome‐wide association study (GWAS) database and the International League Against Epilepsy
Sirui Chen, Ningning Zhang, Ruirui Zhang, Lan Zhang, Dadong Luo, Junqiang Li, Yaqing Liu, Yunan Wang, Xinyue Duan, Xin Tian, Tiancheng Wang   +10 more
wiley   +1 more source

New‐Onset Type 2 Diabetes Mellitus and Cancer Risk: A Matched Cohort Study in China Kadoorie Biobank

International Journal of Cancer, EarlyView.
ABSTRACT The prevalence of type 2 diabetes mellitus (T2DM) is rising rapidly in China and is linked to increased cancer risk, but causality remains unclear due to biases. We examined the causal effect of T2DM on cancer risk using bias‐minimizing methods.
Mengying Wang, Owen Tipping, Bowen Liu, Derrick A. Bennett, Baiyong Shen, Siyi Zou, Shulin Zhao, Richard M. Martin, Matthew Sperrin, Andrew G. Renehan   +9 more
wiley   +1 more source

Causal and mediating effects of lipid and facial aging: association study integrating GWAS, eQTL, mQTL, and pQTL data

Lipids in Health and Disease
Background Increasing evidence suggests a potential causal association between lipid levels and facial aging. The aim of this study was to investigate the relationship between levels of specific lipids and facial aging via Mendelian randomization methods.
Mingjian Zhao, Zhanchen He, Lukuan Liu, Yichen Wang, LinQi Gao, Yuxuan Shang, Mengru Zhu   +6 more
doaj   +1 more source

Proteome‐Wide Mendelian Randomization Identifies Therapeutic Targets for Abdominal Aortic Aneurysm

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The proteome is a key source of therapeutic targets. We conducted a comprehensive Mendelian randomization analysis across the proteome to identify potential protein markers and therapeutic targets for abdominal aortic aneurysm (AAA).
Ka Zhang, Yuan Liu, Aiqin Mao, Changzhu Li, Li Geng, Hao Kan   +5 more
doaj   +1 more source