Results 281 to 290 of about 72,268 (331)

Breeding 5.0: Artificial intelligence (AI)‐decoded germplasm for accelerated crop innovation

Journal of Integrative Plant Biology, EarlyView.
ABSTRACT Crop breeding technologies are vital for global food security. While traditional methods have improved yield, stress tolerance, and nutrition, rising challenges such as climate instability, land loss, and pest pressure now demand new solutions.
Jiayi Fu, Shouzhi Zheng, Longjiang Fan, Xiaoming Zheng, Qian Qian   +4 more
wiley   +1 more source

Unraveling the causal landscape of intervertebral disc degeneration: A Mendelian randomization analysis of 108 traits. [PDF]

Medicine (Baltimore)
Zeng B, Xu S, Zhou D, Chen R, Ding Y, Wu Z, Zheng Z, Liu M, He B, Li S, Bao M.   +10 more
europepmc   +1 more source

Cyclin‐dependent kinase 13 is indispensable for normal mouse heart development

Journal of Anatomy, Volume 246, Issue 4, Page 616-630, April 2025.
Congenital heart disease (CHD) is the most common defect in live births. The role of cyclin‐dependent kinase (CDK13) in cardiogenesis and CHD was studied using a transgenic mouse model (Cdk13tm1b) carrying deletion of exons 3 and 4, causing loss of function.
Qazi Waheed‐Ullah, Anna Wilsdon, Aseel Abbad, Sophie Rochette, Frances Bu'Lock, Asma Ali Saed, Marc‐Phillip Hitz, J. David Brook, Siobhan Loughna   +8 more
wiley   +1 more source

Glaucoma and cardiovascular disease: a bidirectional two-sample Mendelian randomization analysis. [PDF]

Exp Biol Med (Maywood)
Jin D, Sun J, Zhang W, Zhang M, Li C.
europepmc   +1 more source

A Principled Framework for Mendelian Randomization in Oral Health Research

Journal of Periodontal Research, EarlyView.
This methodological article provides a clear and accessible overview of Mendelian randomization for oral health researchers, emphasizing the core assumptions needed for credible causal inference. Focusing on applications in oral health, particularly periodontitis, it highlights both the strengths and limitations of the study design in order to support ...
Nasir Z. Bashir, Mario Romandini, Moritz Kebschull, Konstantinos K. Tsilidis, Dominique S. Michaud, Stephen Burgess   +5 more
wiley   +1 more source

Genetic Susceptibility to Periodontitis

Journal of Periodontal Research, EarlyView.
Aim: The aim of this narrative review was to identify genes carrying risk alleles associated with an increased risk of periodontitis and to place them in a biological context. Methods: The literature was reviewed based on predefined criteria. Results: The identified genes largely fall into functions linking immune response with tissue repair. The genes
Gesa M. Richter, Arne S. Schaefer
wiley   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Groeger Sabine Elisabeth, Zhou Yuxi, Yong Jiawen, Wang Lei, Ruf Sabine, Meyle Joerg   +5 more
wiley   +1 more source

Sleep and Trajectories of Respiratory and Allergic Symptoms Between 1 and 5.5 Years of Age in the Elfe Birth Cohort

Journal of Sleep Research, EarlyView.
ABSTRACT Sleep troubles and respiratory and allergic health issues are associated in children, but the timeline of their association is overlooked. This study investigates the associations between sleep patterns at age 1 and respiratory and allergic multi‐trajectories (RespA‐MTG) between ages 1 and 5.5, and the associations between these multi ...
Daniele Saade, Rosalie Delvert, Chantal Raherison‐Semjen, Orianne Dumas, Mohammed Sedki, Marie‐Noëlle Dufourg, Blandine de Lauzon‐Guillain, Bénédicte Leynaert, Rachel Nadif, Annabelle Bédard, Sabine Plancoulaine   +10 more
wiley   +1 more source

A PLETHORA3/7 transcription factor shapes cucumber shoot architecture

New Phytologist, EarlyView.
Summary PLETHORA transcription factors (PLTs) are master regulators of plant development. Loss of shoot meristematic PLTs leads to reduced phyllotactic regularity and robustness in Arabidopsis and increased inflorescence branching in tomato. Whether these factors have similar functions in other species is not known.
Merijn Kerstens, Florian Müller, Kelvin Adema, Olga Kulikova, Magdalena Lastdrager, Ben Scheres, Viola Willemsen   +6 more
wiley   +1 more source

A Review of the Effects of Maternal and Paternal Obesity on Neurodevelopmental Disorders and Related Neurobiology in Rodent and Human Offspring

Obesity Reviews, EarlyView.
ABSTRACT Obesity is one of the most prevalent health problems worldwide, and global obesity rates continue to rise. Consequently, rates of obesity in expecting mothers and fathers have also increased. The Developmental Origins of Health and Disease (DOHaD) hypothesis postulates that early‐life exposure to adverse environmental conditions contributes to
Hannah Chadwick, Victorio Bambini Junior, Neil Dawson, Cheryl A. Hawkes   +3 more
wiley   +1 more source