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PM2.5 associates with blood pressure: a Mendelian randomization analysis
International Journal of Environmental Health ResearchThe relationship between fine particulate matter (PM2.5) and blood pressure (BP) is a controversial issue. We conducted a two-sample Mendelian randomization (MR) analysis and identified 58 genome-wide significant single-nucleotide polymorphisms associated with PM2.5 as instrument variables.
Minghui, Bao +3 more
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Integration of latent factor analysis into multivariable Mendelian randomization
European Journal of EpidemiologyMendelian randomization has emerged as a powerful tool for exploring causal relationships in observational studies by using genetic variants as instrumental variables. While multivariable Mendelian randomization extends this approach to simultaneously address multiple exposures, it faces significant challenges with highly correlated exposures ...
Yuankai Zhang +7 more
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Apolipoprotein and peripheral artery disease: Mendelian randomization analysis
VascularBackground The prevalence of peripheral arterial disease (PAD) is on the rise globally, leading to adverse clinical outcomes. Our aim was to investigate the causal relationship between apolipoprotein and PAD, as well as the potential mediating role of smoking, diabetes, hypertension, myocardial infarction, and ...
Chen-Xin Wan, Yu-Shu Gong, Tao Xu
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Dyslipidemia and Risk of Preeclampsia: A Multiancestry Mendelian Randomization Study
Hypertension, 2023Hillary Hosier +2 more
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Two-Sample Multivariable Mendelian Randomization Analysis Using R
Current Protocols, 2021Danielle Rasooly, Gina M Peloso
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