Results 121 to 130 of about 8,221 (187)

The multiple faces of leukocyte interstitial migration

, 2014
Spatiotemporal control of leukocyte dynamics within tissues is critical for successful innate and adaptive immune responses. Homeostatic trafficking and coordinated infiltration into and within sites of inflammation and infection rely on signaling in ...
Germain, R., Lämmermann, T.
core   +1 more source

Piezo1 agonist restores meningeal lymphatic vessels, drainage, and brain-CSF perfusion in craniosynostosis and aged mice

The Journal of Clinical Investigation
Skull development coincides with the onset of cerebrospinal fluid (CSF) circulation, brain-CSF perfusion, and meningeal lymphangiogenesis, processes essential for brain waste clearance.
Matt J. Matrongolo, Phillip S. Ang, Junbing Wu, Aditya Jain, Joshua K. Thackray, Akash Reddy, Chi Chang Sung, Gaëtan Barbet, Young-Kwon Hong, Max A. Tischfield   +9 more
doaj   +1 more source

Non-invasive modulation of meningeal lymphatics ameliorates ageing and Alzheimer’s disease-associated pathology and cognition in mice

Nature Communications
Meningeal lymphatic vessels (mLVs) have been shown to be involved in amyloid beta (Aβ) clearance, which is considered as a potential therapeutic target for Alzheimer’s disease (AD).
Miao Wang, Congcong Yan, Xi Li, Tianhao Yang, Shengnan Wu, Qian Liu, Qingming Luo, Feifan Zhou   +7 more
doaj   +1 more source

Photoacoustic detecting of brain lymphatic dysfunction in inflammatory models

Journal of Innovative Optical Health Sciences
The brain lymphatic system plays a crucial role in maintaining homeostasis, clearing metabolic waste, and regulating neuroinflammation. Its dysfunction is strongly linked to neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease ...
Meng Wang, Dan Wang, Zhigang Wang, Wenbin Shi, Zhiyang Wang   +4 more
doaj   +1 more source

Meningeal lymphatic function promotes oligodendrocyte survival and brain myelination [PDF]

The precise neurophysiological changes prompted by meningeal lymphatic dysfunction remain unclear. Here, we showed that inducing meningeal lymphatic vessel ablation in adult mice led to gene expression changes in glial cells, followed by reductions in ...
Almeida, Francisco, Barber, Megan J, Cucuzza, Chiara Starvaggi, Da Mesquita, Sandro, das Neves, Sofia P, Delivanoglou, Nickoleta, Faroqi, Ayman H, Irani, Sarosh R, Makuch, Mateusz, McLean, Pamela J, Oliveira, Tiago Gil, Piehl, Fredrik, Rego, Shanon, Ren, Yingxue, Sanchez, Guadalupe, Schrader, Racquelle, Thomas, Jean-Leon   +16 more
core   +2 more sources

Deep brain lymphatic vessels: a new player in brain functions, neurodegenerative diseases and psychiatric disorders

Stress and Brain
The brain was previously believed to be an “immune privileged” organ without an immune system. However, recent discoveries have shown a connection between the peripheral lymphatic system and the brain.
Bingqing Guo, Junzhuang Chang, Nashat Abumaria   +2 more
doaj   +1 more source

Cardiac lymphatic vessels, transport, and healing of the infarcted heart [PDF]

, 2017
Huang, Li-Hao, Lavine, Kory J, Randolph, Gwendalyn J   +2 more
core   +2 more sources

Meningeal lymphatic supporting cells govern the formation and maintenance of zebrafish mural lymphatic endothelial cells

Nature Communications
The meninges are critical for the brain functions, but the diversity of meningeal cell types and intercellular interactions have yet to be thoroughly examined. Here we identify a population of meningeal lymphatic supporting cells (mLSCs) in the zebrafish
Xiang He, Daiqin Xiong, Lei Zhao, Jialong Fu, Lingfei Luo   +4 more
doaj   +1 more source

Structural and functional conservation of non-lumenized lymphatic endothelial cells in the mammalian leptomeninges [PDF]

, 2019
The vertebrate CNS is surrounded by the meninges, a protective barrier comprised of the outer dura mater and the inner leptomeninges, which includes the arachnoid and pial layers.
Barber, M, Benson, BC, Castellan, RFP, Correra, RM, Faro, A, Foti, SC, Goodman, JR, Grieg, A, Hawkins, TA, Iliff, JJ, Lashley, T, Rihel, J, Ruhrberg, C, Shibata-Germanos, S, Trivedi, CA, Weller, RO   +15 more
core  

The Ins and Outs of B Cells in Multiple Sclerosis [PDF]

, 2015
Gregory P. Owens, Jeffrey L. Bennett, Kevin Blauth   +2 more
core   +1 more source