Results 151 to 160 of about 327,511 (299)

Persistence of quantal synaptic vesicle recycling in virtual absence of dynamins

The Journal of Physiology, EarlyView.
Abstract figure legend Figure depicts the key finding from this study. While loss of all dynamins severely debilitates synaptic vesicle retrieval following repetitive activity, retrieval and recycling of individual synaptic vesicles following spontaneous fusion or sparse stimulation are minimally affected.
Olusoji A. T. Afuwape, Natali L. Chanaday, Merve Kasap, Lisa M. Monteggia, Ege T. Kavalali   +4 more
wiley   +1 more source

Analysis of Risk Factors for Meningeal Metastasis in Patients 
with Lung Adenocarcinoma Following Non-surgical Interventions

Chinese Journal of Lung Cancer
Background and objective Meningeal metastasis (MM) is a form of malignant metastasis where tumor cells spread from the primary site to the pia mater, dura mater, arachnoid, subarachnoid space, and other cerebrospinal fluid compartments.
Yi YUE, Yuqing REN, Jianlong LIN, Chunya LU, Nan JIANG, Yanping SU, Jing LI, Yibo WANG, Sihui WANG, Junkai FU, Mengrui KONG, Guojun ZHANG   +11 more
doaj   +1 more source

Protonentherapie mit "Spot-Scanning" bei Rhabdomyosarkomen im frühen Kindesalter: Erste Erfahrungen am PSI [PDF]

, 2018
Ziel:: Die Durchführbarkeit und Verträglichkeit der Spot-Scanning-Protonentherapie in tiefer Sedierung bei Kindern mit Rhabdomyosarkomen (RMS) sollten geprüft werden. Patienten und Methodik:: Seit 2004 werden junge Kinder am Paul Scherrer Institut (PSI),
Goitein, Gudrun, Lomax, Anthony, Niggli, Felix, Schuck, Andreas, Timmermann, Beate, Weiss, Markus   +5 more
core  

Managing hydrocephalus in patients with leptomeningeal disease: A multicenter retrospective analysis

International Journal of Cancer, Volume 157, Issue 8, Page 1613-1624, 15 October 2025.
What's New? Leptomeningeal disease is a highly palliative condition of tumor cell seeding that can cause symptomatic hydrocephalus. This multi‐center retrospective study of patients with leptomeningeal disease‐associated hydrocephalus compared the placement of ventriculoperitoneal shunts and Rickham reservoirs for cerebrospinal fluid drainage.
Obada T. Alhalabi, Lukas Klein, David Wasilewski, Amine Mellal, Carmen Büsken, Clara Buszello, Giulia Cossu, Ilker Y. Eyüpoglu, Andreas W. Unterberg, Peter Vajkoczy, Gabriele Schackert, Mahmoud Messerer, Martin Misch, Tobias Kessler, Wolfgang Wick, Christine Jungk, Ahmed El Damaty, Sandro M. Krieg, Tareq A. Juratli, Alexander Younsi   +19 more
wiley   +1 more source

Metastases in Meckel's Cave: A Challenge of Differential Diagnosis [PDF]

, 2018
Metastases in Meckel's cave are a rare tumor entity and should be considered as important differential diagnosis, especially if the patient presents with trigeminal neuralgia and suffers from a known primary malignancy. We present three cases of patients
Kollias, Spyros, Krayenbühl, Niklaus, Scheffel, Hans, Theuer, Susanne, Yonekawa, Yasuhiro   +4 more
core  

Clinical Features and Therapeutic Evaluation of Central Nervous System Involvement in Pediatric Anaplastic Large Cell Lymphoma

Pediatric Blood &Cancer, Volume 72, Issue 10, October 2025.
ABSTRACT Background This study analyzed the clinical features of central nervous system involvement (CNS3) in pediatric anaplastic large cell lymphoma (ALCL) and evaluated the CNCL‐ALCL‐2017 treatment protocol efficacy. Methods The clinical data of 215 pediatric ALCL patients aged ≤18 years, including 16 with CNS3, treated following the CNCL‐ALCL‐2017 ...
Xiaomei Yang, Jing Yang, Shuang Huang, Yanlong Duan, Ling Jin, Lian Du, Luping Ding, Mincui Zheng, Pan Wu, Ying Liu, Bo Hu, Yunpeng Dai, Guotao Guan, Ansheng Liu, Shuang Qin, Leping Zhang, Yueping Jia, Lirong Sun, Jian Jiang, Jian Wang, Lijun Qu, Xiaojun Yuan, Yushuang Dong, Wei Liu, Jianwen Zhou, Baoxi Zhang, Chunju Zhou, Zifen Gao, Fu Li, Yonghong Zhang   +29 more
wiley   +1 more source

Histologically verified penile lichen sclerosus—Incidence in Denmark over 26 years and long‐term risk of penile and non‐penile cancer

International Journal of Cancer, Volume 157, Issue 6, Page 1086-1093, 15 September 2025.
What's new? About half of penile squamous cell carcinomas are causally associated with inflammatory conditions such as lichen sclerosus (LSc), but few large‐scale studies have assessed the risk of penile cancer in men with LSc. Here, the authors conducted a large nationwide study in Denmark to estimate the risk of penile and non‐penile cancer in men ...
Marianne Gardar Stærk, Emma L. Kaderly Rasmussen, Charlotte Gerd Hannibal, Rasmus Hertzum‐Larsen, Louise Baandrup, Susanne K. Kjær   +5 more
wiley   +1 more source

Stroke Mimicry: Unmasking a Brainstem Tuberculoma in a Young Patient

Clinical Case Reports, Volume 13, Issue 9, September 2025.
A young male presented with stroke‐like symptoms ‐ progressive hemiparesis and cranial nerve palsies. MRI brain revealed a ring‐enhancing intrapontine lesion with perilesional edema, suggestive of tuberculoma. Early initiation of anti‐tubercular therapy led to complete recovery.
Nithish Nanda Palanisamy, Dhiran Sivasubramanian, Virushnee Senthilkumar, Smrti Aravind, Sathwik Sanil, Karthick Balasubramanian   +5 more
wiley   +1 more source

Spatiotemporal Dynamics of Central Nervous System Diseases: Advancing Translational Neuropathology via Single‐Cell and Spatial Multiomics

MedComm, Volume 6, Issue 9, September 2025.
Central nervous system (CNS) diseases are driven by spatiotemporally dynamic molecular networks. Single‐cell and spatial multiomics technologies dissect cellular heterogeneity, microenvironmental remodeling, and intercellular crosstalk. Integration of transcriptomic, epigenomic, proteomic, and metabolomic layers reveals disease‐associated regulatory ...
Mingkai Xia, Quan Liu, Wenli Zhang, Jinwen Ge, Zhigang Mei   +4 more
wiley   +1 more source

Activity and Heterogeneity of Astrocytes in Neurological Diseases: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 6, Issue 9, September 2025.
Astrocytes display heterogeneity in various neurological disorders and behavioral neuropsychiatric disorders. Astrocytes influence the progression of neurological diseases through neuroinflammation, oxidative stress, metabolic abnormalities, intercellular interactions, and a spectrum of other pathophysiological processes.
Shijie Mao, Rui Qiao, Qi Wang, Ling Shen, Daxing Li, Xinchen Huo, Jindou Wang, Kunxuan Liu, Wenjing Chen, Tianhao Zhu, Beicheng Zhang, Shuo Leng, Ying Bai   +12 more
wiley   +1 more source