Results 151 to 160 of about 42,235 (304)

Protonentherapie mit "Spot-Scanning" bei Rhabdomyosarkomen im frühen Kindesalter: Erste Erfahrungen am PSI [PDF]

, 2018
Ziel:: Die Durchführbarkeit und Verträglichkeit der Spot-Scanning-Protonentherapie in tiefer Sedierung bei Kindern mit Rhabdomyosarkomen (RMS) sollten geprüft werden. Patienten und Methodik:: Seit 2004 werden junge Kinder am Paul Scherrer Institut (PSI),
Goitein, Gudrun, Lomax, Anthony, Niggli, Felix, Schuck, Andreas, Timmermann, Beate, Weiss, Markus   +5 more
core  

Malignant Neoplasm of the Meninges [PDF]

, 2020
openaire   +1 more source

Organ‐specific low‐dose assessment in pediatric radiotherapy using nanodot OSL and NTCP modeling: Application to medulloblastoma

Journal of Applied Clinical Medical Physics, Volume 27, Issue 1, January 2026.
Abstract Background In pediatric radiotherapy, controlling low‐dose exposure is a major challenge, particularly in the treatment of medulloblastoma, where the long life expectancy of young patients makes optimization of radioprotection crucial. Purpose This study provides a comprehensive and quantitative assessment of low‐dose exposure to normal ...
Meriem Tantaoui, Mustapha Krim, Fatimzahra Chehab, El Mehdi Essaidi, Mohammed Reda Mesradi, Abdelkrim Kartouni, Souha Sahraoui   +6 more
wiley   +1 more source

Macrophages Mediate Mesoscale Brain Mechanical Homeostasis

Advanced Materials, Volume 38, Issue 6, 27 January 2026.
We investigated the role of infiltrating immune cells in sculpting the developing brain. Using Brillouin microscopy and active microrheology, we found microglia actively maintain tissue viscoelasticity. Moreover, colony stimulating factor one receptor (CSF1R)‐driven stromal remodeling alters brain mechanics in vivo. These findings link immune activity,
Woong Young So, Bailey Johnson, Patricia B. Gordon, Kevin S. Bishop, Hyeyeon Gong, Hannah A Burr, Jack Rory Staunton, Chenchen Handler, Khanh Loan Ly, Raman Sood, Giuliano Scarcelli, Kandice Tanner   +11 more
wiley   +1 more source

Analysis of Risk Factors for Meningeal Metastasis in Patients 
with Lung Adenocarcinoma Following Non-surgical Interventions

Chinese Journal of Lung Cancer
Background and objective Meningeal metastasis (MM) is a form of malignant metastasis where tumor cells spread from the primary site to the pia mater, dura mater, arachnoid, subarachnoid space, and other cerebrospinal fluid compartments.
Yi YUE, Yuqing REN, Jianlong LIN, Chunya LU, Nan JIANG, Yanping SU, Jing LI, Yibo WANG, Sihui WANG, Junkai FU, Mengrui KONG, Guojun ZHANG   +11 more
doaj   +1 more source

Mechanical Environment Afforded by Engineered Hydrogel Critically Regulates Survival of Neural Stem Cells Transplanted in the Injured Spinal Cord via Piezo1‐Mediated Mechanotransduction

Advanced Science, Volume 13, Issue 3, 14 January 2026.
Neural stem cell transplantation shows promise for spinal cord repair, but poor graft survival limits therapeutic efficacy. This study demonstrates that increasing hydrogel stiffness from 10% to 16% concentration significantly enhances transplanted neural stem cell survival through Piezo1‐mediated mechanotransduction, revealing mechanical properties as
Hee Hwan Park, Yurim Kim, Byeong Seong Jang, Simay Genişcan, Dong Hoon Hwang, Yeojin Seo, Seung‐Ah Jee, Hyo Gyeong Seo, Hyung Soon Kim, Ariandokht Einisadr, Ho‐Jeong Kim, Seolhee Lee, Sangwoo Kwon, Kyung Sook Kim, Kang In Lee, Jae Young Lee, Joo Min Park, Young‐Min Kim, Soo‐Chang Song, Byung Gon Kim   +19 more
wiley   +1 more source

Morphine Tolerance Gated through EZH2‐Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan, Mengyao Zhang, Haiyue Guo, Yan Xu, Chenjie Xu, Fan Hu, Yinbing Pan, Xian Wang, Wentao Liu, Chun‐Yi Jiang   +9 more
wiley   +1 more source

Stromal Cell‐Mast Cell Communication Orchestrates Anti‐Viral Immunity in the Meninges

Advanced Science, Volume 13, Issue 5, 27 January 2026.
This study delineates the spatial distribution and postnatal maturation of meningeal mast cells and uncovers their essential role in antiviral immunity. Using genetic models, mast cells are shown to promote CD8⁺ T cell infiltration and viral clearance via IL‐33 receptor signaling and synergistic activation by IL‐33 and ATP from infected stromal cells ...
Qingqing Li, Weijia Chen, Mengxue Sun, Xinbo Ni, Qishan Ran, Xiaoyu Hu, Fang Cao, Wenwen Zeng   +7 more
wiley   +1 more source

Astrocyte–vascular interplay in Alzheimer's disease pathology: Novel insights into stage‐specific biomarkers and therapeutic targets

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION We examined how neurovascular and astrocytic response alter cognition in Alzheimer's disease (AD). METHODS Cognitive scores, biomarkers of AD and astrocytic activation, vascular factors, and brain structure data from 693 Alzheimer's Disease Neuroimaging Initiative (ADNI) participants were analyzed using analysis of covariance ...
Zehu Sheng, Yuhao Chen, Ming Chen, Shuyu Liang, Jingyi Wang, Yingxi Chen, Rengui Li, Boyuan Xia, Kangjinyuan Gou, Siyuan Liu, Alzheimer's Disease Neuroimaging Initiative, Weihua Yu, Yang Lü   +12 more
wiley   +1 more source

The Clinical Characteristics and Treatment of Patients With Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy (GFAP‐A): A Retrospective Study of 29 Patients

Brain and Behavior, Volume 16, Issue 1, January 2026.
A retrospective analysis of clinical features, treatment, and outcome of 29 patients with autoimmune glial fibrillary acidic protein astrocytopathy (GFAP‐A). Cerebrospinal fluid (CSF) pressure, CSF nucleated cell count, CSF protein levels, CSF chloride, serum thyroid dysfunction, and abnormal blood cytokine levels correlated with disease severity but ...
Xuewei Yang, Lanling Jin, Chanhong Shi, Hongwei Yue, Hongfei He, Wenli Zhu, Ruili Wei   +6 more
wiley   +1 more source