Results 11 to 20 of about 112,287 (262)

A Skull Bone Marrow‐to‐Brain Axis Links Osteoblastic Activity to Myeloid Cell Trafficking, Cerebral Blood Flow, and Cognition in Alzheimer's Progression

Advanced Science
Patients with Alzheimer's disease (AD) often develop osteoporosis, but the role of bone remodeling in AD remains unclear. We previously showed that osteoblast‐specific expression of APPswe induces bone loss, glial activation, and behavioral deficits ...
Lei Xiong, Dong Sun, Hao‐Han Guo, Daehoon Lee, Zhipeng Liu, Lin Mei, Wen‐Cheng Xiong   +6 more
doaj   +2 more sources

Fibrosarcoma of the meninges

Rare Tumors, 2010
Meningeal fibrosarcomas are rare tumors. Only 41 cases have been reported in the literature to date. Primary central nervous system fibrosarcomas are very aggressive neoplasms and have a poor prognosis. Hence they need to be correctly diagnosed.
Ishwar Chand Premsagar, Minakshi Bhardwaj, Ruchi Chopra   +2 more
doaj   +1 more source

Translationally Relevant Magnetic Resonance Imaging Markers in a Ferret Model of Closed Head Injury

Frontiers in Neuroscience, 2022
Pre-clinical models of traumatic brain injury (TBI) have been the primary experimental tool for understanding the potential mechanisms and cellular alterations that follow brain injury, but the human relevance and translational value of these models are ...
Elizabeth B. Hutchinson, Anakaren Romero-Lozano, Hannah R. Johnson, Andrew K. Knutsen, Andrew K. Knutsen, Asamoah Bosomtwi, Asamoah Bosomtwi, Alexandru Korotcov, Alexandru Korotcov, Anandakumar Shunmugavel, Anandakumar Shunmugavel, Sarah G. King, Susan C. Schwerin, Susan C. Schwerin, Sharon L. Juliano, Sharon L. Juliano, Bernard J. Dardzinski, Bernard J. Dardzinski, Carlo Pierpaoli   +18 more
doaj   +1 more source

Preliminary study on double ⁃ dose icotinib successfully treated leptomeningeal metastasis in lung adenocarcinoma patient with EGFR gene sensitive mutation

Chinese Journal of Contemporary Neurology and Neurosurgery, 2021
Objective To report the diagnosis and treatment of a patient with meningeal metastases from lung adenocarcinoma, and explore the significance of cerebrospinal fluid (CSF) gene detection for clinical treatment and the efficacy and safety of double⁃dose ...
LIU Mei, MU Ning, MA Chun⁃hua, LI Jin⁃duo, LI Lin, JIANG Rong   +5 more
doaj   +1 more source

High Yield of Adult Oligodendrocyte Lineage Cells Obtained from Meningeal Biopsy

Frontiers in Pharmacology, 2017
Oligodendrocyte loss can lead to cognitive and motor deficits. Current remyelinating therapeutic strategies imply either modulation of endogenous oligodendrocyte precursors or transplantation of in vitro expanded oligodendrocytes.
Sissi Dolci, Annachiara Pino, Valeria Berton, Pau Gonzalez, Alice Braga, Marta Fumagalli, Elisabetta Bonfanti, Giorgio Malpeli, Francesca Pari, Stefania Zorzin, Clelia Amoroso, Denny Moscon, Francisco J. Rodriguez, Guido Fumagalli, Francesco Bifari, Ilaria Decimo   +15 more
doaj   +1 more source

Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI

eLife, 2017
Here, we report the existence of meningeal lymphatic vessels in human and nonhuman primates (common marmoset monkeys) and the feasibility of noninvasively imaging and mapping them in vivo with high-resolution, clinical MRI.
Martina Absinta, Seung-Kwon Ha, Govind Nair, Pascal Sati, Nicholas J Luciano, Maryknoll Palisoc, Antoine Louveau, Kareem A Zaghloul, Stefania Pittaluga, Jonathan Kipnis, Daniel S Reich   +10 more
doaj   +1 more source

Cholinergic Nociceptive Mechanisms in Rat Meninges and Trigeminal Ganglia: Potential Implications for Migraine Pain

Frontiers in Neurology, 2017
BackgroundParasympathetic innervation of meninges and ability of carbachol, acetylcholine (ACh) receptor (AChR) agonist, to induce headaches suggests contribution of cholinergic mechanisms to primary headaches.
Rashid Giniatullin, Rashid Giniatullin, Irina Shelukhina, Irina Shelukhina, Nikita Mikhailov, Polina Abushik, Leniz Nurullin, Leniz Nurullin, Evgeny E. Nikolsky, Evgeny E. Nikolsky   +9 more
doaj   +1 more source

A neoplasm associated with the meninges of the spinal canal – a case report

Journal of Education, Health and Sport, 2019
Introduction: Spinal canal neoplasms are a heterogeneous group of diseases including both primary and metastatic tumors, either benign or malignant. These tumors can develop both intraspinally and peripherally.
Marcin Kulczyński, Klaudia Sapko, Michał Marciniec, Kinga Caban   +3 more
doaj   +3 more sources

TRP Channels and Migraine: Recent Developments and New Therapeutic Opportunities

Pharmaceuticals, 2019
Migraine is the second-most disabling disease worldwide, and the second most common neurological disorder. Attacks can last many hours or days, and consist of multiple symptoms including headache, nausea, vomiting, hypersensitivity to stimuli such as ...
Silvia Benemei, Greg Dussor
doaj   +1 more source

Dwellers and Trespassers: Mononuclear Phagocytes at the Borders of the Central Nervous System

Frontiers in Immunology, 2021
The central nervous system (CNS) parenchyma is enclosed and protected by a multilayered system of cellular and acellular barriers, functionally separating glia and neurons from peripheral circulation and blood-borne immune cells. Populating these borders
Daniela C. Ivan, Sabrina Walthert, Kristina Berve, Jasmin Steudler, Giuseppe Locatelli   +4 more
doaj   +1 more source