Results 41 to 50 of about 11,289 (180)

De novo or Salvage? Nucleotide Availability as a Driver of Bacterial Adaptation and Virulence

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Bacterial pathogens survive in different host environments by switching between making nucleotides by de novo synthesis and scavenging them from the host. This flexibility supports growth and virulence making nucleotide metabolism an attractive therapeutic target.
Riya Joshi, Alastair G. McEwan, Ulrike Kappler   +2 more
wiley   +1 more source

Central Nervous System Vasculitis for Cryptococcosis in an Immunocompetent Patient

Diseases, 2018
Cryptococcal meningitis is a life-threatening condition caused by a fungal pathogen, Cryptococcus neoformans, that can infect both immunosuppressed and immunocompetent hosts. It is an important cause of morbidity and mortality in severely immunodeficient
Dan Zimelewicz Oberman, Liliana Patrucco, Carolina Cuello Oderiz   +2 more
doaj   +1 more source

Gingival enlargement and dentition loss associated with disseminated Cryptococcus neoformans infection in a dog

Veterinary Record Case Reports, Volume 14, Issue 3, August 2026.
Abstract A 1‐year‐old, female, spayed, mixed‐breed dog was examined by a referring veterinarian for a 1‐week history of sneezing, bilateral mucoid nasal discharge, mild bilateral ocular discharge and stertor. During rhinoscopy, a plant awn foreign body was removed, but upper respiratory signs persisted. Computed tomography of the head revealed findings
Glynn Woods, Allison Volk, Janny Evenhuis, Abbie Metcalfe, Jane E. Sykes   +4 more
wiley   +1 more source

Experiences of diagnosis and treatment of 102 cases with cryptococcal meningitis and/or cryptococcal meningoencephalitis

Chinese Journal of Contemporary Neurology and Neurosurgery, 2014
Objective To summarize the clinical manifestations and diagnostic and therapeutic strategies of 102 cases with cryptococcal meningitis and/or cryptococcal meningoencephalitis, and to improve the diagnosis and treatment of cryptococcal meningitis ...
Yan-yu CHANG, Xue-qiang HU
doaj  

Cryptococcus meningitis mimicking cerebral septic emboli, a case report series demonstrating injection drug use as a risk factor for development of disseminated disease

BMC Infectious Diseases, 2020
Background Clinicians may be less inclined to consider a diagnosis of cryptococcal meningitis in people without HIV infection or transplant-related immunosuppression. This may lead to a delay in diagnosis particularly if disseminated cryptococcal disease
Christopher Polk, Jacqueline Meredith, Alyssa Kuprenas, Michael Leonard   +3 more
doaj   +1 more source

Infection control in the brain and the eye

Acta Ophthalmologica, Volume 104, Issue 5, Page e478-e490, August 2026.
Abstract The Central Nervous System (CNS), comprising the brain and the eye, is considered to have a ‘privileged’ mechanism for dealing with immunological challenge (immune privilege, IP). CNS IP has been revealed through experiments using foreign protein antigens and cell and tissue alloantigens (grafts), but evidence for a role for IP in modulating ...
John V. Forrester, Paul G. McMenamin, Samantha J. Dando   +2 more
wiley   +1 more source

Cryptococcal meningitis among perinatally HIV‐infected adolescents: Case series on presentation and management challenges

Clinical Case Reports, 2023
Diagnosis and management of cryptococcal meningitis in HIV‐infected adolescents is challenging in poor resource settings. A high index of suspicion based on clinical presentation is critical for early identification and treatment.
Peter Puplampu, Isabella Asamoah, Bismark O. Asare, Kofi P. Berko, Oluwakemi Oladele, Emmanuella Amankwa, Frempong Lambert, Antoinette T. Afriyie, Vincent Ganu   +8 more
doaj   +1 more source

Antifungal Activity and Possible Mechanism of Action of the Zn (II) Complex With a Schiff Base Against Fluconazole‐Resistant Strains of Candida spp. and Cryptococcus neoformans

Chemistry &Biodiversity, Volume 23, Issue 7, July 2026.
Addressing the global challenge of antifungal resistance, this work presents a vanillin‐derived Schiff base complexed with zinc (II) (SBZ) with potent activity against fluconazole‐resistant Candida spp. and Cryptococcus neoformans. By activating an apoptotic pathway, ranging from mitochondrial depolarization and oxidative stress to fungal DNA ...
Lívia Gurgel do Amaral Valente Sá, Cecília Rocha da Silva, João Batista de Andrade Neto, Daniel Sampaio Rodrigues, Lara Elloyse Almeida Moreira Gomes, Vitória Pessoa de Farias Cabral, Wildson Max Barbosa da Silva, Solange de Oliveira Pinheiro, Jordana Lima Braga, Bruno Coêlho Cavalcanti, Manoel Odorico de Moraes, Thais Lima Ferreira, Elaine Aires de Lima, Ana Carolina Medeiros de Oliveira, Hélio Vitoriano Nobre Júnior   +14 more
wiley   +1 more source

Central Diabetes Insipidus and Brain Herniation Secondary to Cryptococcal Meningitis in a Dog

Clinical Case Reports, Volume 14, Issue 7, July 2026.
Patient CSF cytology consistent with Cryptococcus fungal infection with eosinophilic inflammation. ABSTRACT Central diabetes insipidus (CDI) should be considered in neurologic patients with persistent polyuria and rising sodium concentrations despite appropriate fluid therapy. Earlier recognition, serial urine concentration monitoring, and desmopressin
Owen Hurst, Alicia Mastrocco, Jennifer Prittie   +2 more
wiley   +1 more source

Extending Trait‐Based Ecology Across Disciplines in the Face of Global Change

Ecology and Evolution, Volume 16, Issue 7, July 2026.
We propose a trait‐based approach, encompassing attributes important to the responsiveness of different systems across disciplines as an effective solution to overcome barriers for cross‐system communication. ABSTRACT Trait‐based ecology has been successful in linking organismal traits to ecological responses under environmental change and to their ...
Thiago Gonçalves‐Souza, Tsun Fung Au, Rose E. Brinkhoff, Morgan R. McPherson, Sarah L. Raubenheimer, Katherine S. Rocci, Yiluan Song, Liting Zheng, Jennifer R. Head, Xinli Chen, Rémi Bardou, Peter B. Reich   +11 more
wiley   +1 more source