Results 91 to 100 of about 20,003 (228)

Extracellular calcium reduction strongly increases the lytic capacity of pneumolysin from streptococcus pneumoniae in brain tissue [PDF]

, 2011
Background. Streptococcus pneumoniae causes serious diseases such as pneumonia and meningitis. Its major pathogenic factor is the cholesterol-dependent cytolysin pneumolysin, which produces lytic pores at high concentrations.
Elke Maier, Fortsch, C., Mitchell, T.J., Benz, Roland, Ma, Jiangtao, Christina Förtsch, Sabrina Hupp, Jiangtao Ma, Timothy J. Mitchell, Iliev, A. I., Maier, Elke, Förtsch, Christina, Maier, E., Hupp, Sabrina, Asparouh I. Iliev, Hupp, S., Mitchell, Timothy J, Roland Benz, Wippel, C., Benz, R., Ma, J., Wippel, Carolin, Iliev, Asparouh I, Carolin Wippel   +23 more
core   +1 more source

Splenectomy in β‐thalassemia patients: Practices and risks in a nationwide study

HemaSphere, Volume 10, Issue 5, May 2026.
Audrey Benoit, Justine Pages, Sarah Szepetowski, Imane Agouti, Isabelle Thuret, Enora Le Roux, Catherine Badens, Valentine Brousse, NaThalY Network, Catherine Mathey, Louisa Bey, Marie‐Josée Lucchini, Valérie Li Thio Te, Reda Garidi, Loïc Garcon, Corentin Orvain, Jean‐François Brasme, Claire Reynes, Marie Belloy, Julie Durin, Oula Alhindy, Lara Sabbagh, Borhane Slama, Anthony Sanchez, Alice Moulin, Danielle Belgodere, Lise Benjemia, Pauline Simon, Eric Oziol, Nathalie Aladjidi, Yoann Huguenin, Charlotte Jubert, Edouard Forcade, Pierre Duffau, Abdallah Maakaroun, Florence Lachenal, Charline Pegon, Marie‐Helene Odievre, Charlotte Petitdidier, Sai Atmani, Florence Raqbi, Corinne Pondarre, Jenny Youn, Annie Kamdem, Dora Bachir, Pablo Bartolucci, Gonzalo De Luna, Anoosha Habibi, Elena Fois, Antoine Leblanc, Pierre‐Yves Dides, Caroline Makowski, Corinne Armari, Narcisse Elenga, Christelle Chantalat‐Auger, Françoise Driss, Ferielle Zenchri, Corinne Guitton, Mathilde Jehanne, Cecile Stoven, Axel Chaminade, Stephanie Gourdon, Yves Reguerre, Edouard Randriamalala, Véronique Paumier‐Bonjour, Anne Besancon‐Bergelin, Anne Lambilliotte, Benedicte Bruno, Fanny Gonzales, Melissa Barbati, Benjamin Carpentier, Christophe Piguet, Mohamed Touati, Arnaud Hot, Fiorenza Barraco, Giovanna Cannas, Emilie Virot, Romain Fort, Grégoire Ducoux, Hélène Desmurs Clavel, Kamila Kebaili, Nathalie Garnier, Cécile Renard, Yves Bertrand, Anne‐Laure Peugnet, Carine Halfon‐Domenech, Judith Diakiesse, Kokou‐Placide Agbo‐Kpati, Nathalie Ravet, Isabelle Thuret, Sarah Szepetowski, Estelle Jean, Benjamin De Sainte Marie, Benoit Meunier, Benoit Faucher, Matias Muszlak, Abdourahim Chamouine, Alain Garou, Caroline Masserot‐Lureau, Jean‐Marc Schneider, Veronique Dorvaux, Philippe Carassou, Honorat Andriamihaja, Muriel Lalande, Perrine Mahe, Anne Sirvent, Patricia Aguilar Martinez, Ivan Bertchansky, Jean‐Claude Eisenmann, Agathe Masseau, Marie‐Laure Couec, Fanny Rialland, Pierre‐Simon Rohrlich, Sandrine Baron‐Joly, Mohamed Conde, Antoine Dossier, Valentine Brousse, Karima Yakouben, Malika Benkerrou, Ghislaine Ithier, Florence Missud, Jean‐Hugues Dalle, Bérengène Koehl, Laurent Holvoet, Jean‐Antoine Ribeil, Laure Joseph, Marina Cavazzana, Marianne De Montalembert, Benedicte Neven, Despina Moshous, Mélissa Taylor, Slimane Allali, Bruno Varet, Gerard Socie, Alienor Xhaard, Régis Peffault De La Tour, Thierry Leblanc, Nicolas Boissel, Marie Robin, Nathalie Dhedin, Robert Girot, Sarah Mattioni, François Lionnet, Jean Donadieu, Guy Leverger, Sylvie Fasola, Jean‐Benoit Arlet, Corina Manoli, Maryse Etienne‐Julan, Emmanuelle Bernit, Justine Gellen‐Dautremer, Stéphanie Eyssette, Gilles Blondin, Claire Pluchart, Stanislas Nimubona, Jacinthe Bonneau, Sophie Bayart, Sophie Pertuisel, Benedicte Collet, Laurence Detourmignies, Julie Machin, Mathieu Wemeau, Laurence De Tourmigni, Jean‐Pierre Vannier, Bruno Filhon, Cecile Dumesnil, Agnes Lahary, Pascale Schneider, Stéphanie Ngo, Aurore Malric, Maud Schoeny, Claire Berger, Isabelle Guichard, Aurélie Desbree, Jean‐Louis Stephan, Audrey David, Catherine Paillard, Alexandra Salmon, Shanti Ame, Philippe Gestas, Marianne Besnard, Marie‐Pierre Castex, Geneviève Plat‐Wilson, Pierre Cougoul, Marlène Pasquet, Jill Serre, Marion Yvert, Jean‐Baptiste Valentin, Francis Duchene, Suzanne Mathieu, Marie Drouilly, Marie Detrait, Cécile Pochon, Aurélie Phulpin, Sylvie Nathanson   +194 more
wiley   +1 more source

Oral Microbiota: Findings, Classification, Clinical Significance, and Therapeutic Interventions for Human Systemic Diseases

iMetaMed, Volume 2, Issue 1, March 2026.
Oral microbiota: findings, classification, clinical significance, and therapeutic interventions for human systemic diseases ABSTRACT The oral microbiota is an ecological community of commensal, symbiotic, and pathogenic microorganisms that colonizes the oral cavity.
Miao Zhang, Meihang Du, Wenjiang Zhang, Renhuan Huang, Wanting Li, Tongqi Li, Junping Bai, Ning Zhang, Jungang Chen, Jing Zhou, Bing Wang, Liwei An, Hideaki Kagami, Yiming Zhang   +13 more
wiley   +1 more source

The alveolar microenvironment of patients infected with human immunodeficiency virus does not modify alveolar macrophage interactions with Streptococcus pneumoniae. [PDF]

, 2013
We tested the hypothesis that HIV infection results in activation of alveolar macrophages and that this might be associated with impaired defense against pneumococcus. We compared alveolar macrophages and lymphocytes in 131 bronchoalveolar lavage samples
Pridmore, Alison, Molyneux, Malcolm E, Molyneux, Malcolm E., Jagoe, R Thomas, Gordon, Stephen, Zijlstra, Eduard E, Jarman, Elizabeth R., North, James C., Read, Robert C., French, Neil, Read, Robert C, Gordon, Stephen B., Musaya, Janelisa, North, James C, Gordon, Stephen B, Jarman, Elizabeth R, Jagoe, R. Thomas, Zijlstra, Eduard E.   +17 more
core   +1 more source

Epidemiologic, clinical and bacteriologic characteristics of pneumococcal meningitis in pediatric patients from Lima, Peru

Revista Peruana de Medicina Experimental y Salud Pública, 2016
Objectives. To describe the clinical characteristics, lethality, antibiotic susceptibility, and serotype distribution of pneumococcal meningitis in pediatric patients in Lima, Peru. Materials and Methods.
Long Davalos, Yessica Terrazas, Ana Quintana, Martha Egoavil, Katherine Sedano, María E. Castillo, Isabel Reyes, Eduardo Chaparro, Wilda Silva, Francisco Campos, Andrés Saenz, Roger Hernandez, Olguita del Águila, Daniel Guillén Pinto, Theresa J. Ochoa   +14 more
doaj   +1 more source

Meningococcal Serogroup Y Meningitis Reveals Inborn Factor B Deficiency

European Journal of Immunology, Volume 56, Issue 2, February 2026.
We report a novel case of complete complement Factor B deficiency revealed by invasive meningococcal disease. Using combined functional and genetic analyses, we demonstrate that loss of Factor B abolishes alternative pathway activity despite detectable protein levels. These findings provide a mechanistic framework relevant to complement diagnostics and
Camille Bougeard, Eléonore Eskander, Paula Vieira Martins, Joan Bitan, Julia Roquigny, Christèle Kyheng, Tamazoust Guiddir, Véronique Frémeaux‐Bacchi, Cécile Gonnin, Carine ElSissy   +9 more
wiley   +1 more source

The ZNF148‐ZEB1‐AS1‐IGF2BP2‐NOD2 Axis Drives Microglial Antipneumococcal Immunity in Bacterial Meningitis

Glia, Volume 74, Issue 2, February 2026.
ZNF148 upregulates ZEB1‐AS1, which scaffolds IGF2BP2 to stabilize NOD2 mRNA, enhancing microglial anti‐pneumococcal immunity via cytokine production and bacterial clearance in bacterial meningitis. ABSTRACT Streptococcus pneumoniae (Spn) meningitis remains a lethal central nervous system (CNS) infection with limited therapies. This study identifies the
Xiufu Hu, Fang Jiang, Xinjie Liu, Ling Li, Ruimei Hu, Meng Dong, Aihua Cao   +6 more
wiley   +1 more source

Pneumococcal Gene Complex Involved in Resistance to Extracellular Oxidative Stress [PDF]

, 2012
Streptococcus pneumoniae is a Gram-positive bacterium which is a member of the normal human nasopharyngeal flora but can also cause serious disease such as pneumonia, bacteremia, and meningitis. Throughout its life cycle, S.
Cecilia A. Hinojosa, Jong, Anne de,, de Jong, Anne; id_orcid, Jetta J. E. Bijlsma, Anne de Jong, Kuipers, Oscar P.; id_orcid, Kuipers, Oscar P., Oscar P. Kuipers, de Jong, Anne, Orihuela, Carlos J.,, Farshchi Andisi, Vahid,, Bijlsma, Jetta J.E.,, Hinojosa, Cecilia A.,, Vahid Farshchi Andisi, Kuipers, Oscar P.,, Carlos J. Orihuela, Farshchi Andisi, Vahid, Bijlsma, Jetta J. E., Hinojosa, Cecilia A., Orihuela, Carlos J.   +19 more
core   +1 more source

Complement factor H contributes to mortality in humans and mice with bacterial meningitis

Journal of Neuroinflammation, 2019
Background The complement system is a vital component of the inflammatory response occurring during bacterial meningitis. Blocking the complement system was shown to improve the outcome of experimental pneumococcal meningitis. Complement factor H (FH) is
E. Soemirien Kasanmoentalib, Mercedes Valls Serón, Joo Yeon Engelen-Lee, Michael W. Tanck, Richard B. Pouw, Gerard van Mierlo, Diana Wouters, Matthew C. Pickering, Arie van der Ende, Taco W. Kuijpers, Matthijs C. Brouwer, Diederik van de Beek   +11 more
doaj   +1 more source

Clinical presentation, treatment, and outcome of children with primary intestinal lymphangiectasia: A national retrospective study

Journal of Pediatric Gastroenterology and Nutrition, Volume 82, Issue 2, Page 398-406, February 2026.
Abstract Objectives Primary intestinal lymphangiectasia (PIL) is a very rare disease responsible for protein‐losing enteropathy. There is little published data about treatments efficacy and outcomes. Our main objective was to describe the clinical profile, response to therapy, and outcomes of children with PIL.
Noémie Goret, Cécile Lambe, Emmanuelle Ecochard‐Dugelay, Alexandre Fabre, Alain Dabadie, Aurélie Comte, Julie Rebeuh, Pierre Poinsot, Emilie Chaillou, Haude Clouzeau, Aurélie Sabard, Béatrice Dubern, Stéphanie Willot   +12 more
wiley   +1 more source