Results 81 to 90 of about 91,384 (218)

Complement factor H contributes to mortality in humans and mice with bacterial meningitis

Journal of Neuroinflammation, 2019
Background The complement system is a vital component of the inflammatory response occurring during bacterial meningitis. Blocking the complement system was shown to improve the outcome of experimental pneumococcal meningitis. Complement factor H (FH) is
E. Soemirien Kasanmoentalib, Mercedes Valls Serón, Joo Yeon Engelen-Lee, Michael W. Tanck, Richard B. Pouw, Gerard van Mierlo, Diana Wouters, Matthew C. Pickering, Arie van der Ende, Taco W. Kuijpers, Matthijs C. Brouwer, Diederik van de Beek   +11 more
doaj   +1 more source

National, regional, and state-level burden of Streptococcus pneumoniae and Haemophilus influenzae type b disease in children in India: modelled estimates for 2000–15

The Lancet Global Health, 2019
Summary: Background: India accounts for a disproportionate burden of global childhood illnesses. To inform policies and measure progress towards achieving child health targets, we estimated the annual national and state-specific childhood mortality and ...
Brian Wahl, PhD, Apoorva Sharan, ScM, Maria Deloria Knoll, PhD, Rajesh Kumar, ProfMD, Li Liu, PhD, Yue Chu, MSPH, David A McAllister, MD, Harish Nair, ProfPhD, Harry Campbell, ProfMD, Igor Rudan, ProfMD, Usha Ram, ProfPhD, Molly Sauer, MPH, Anita Shet, MD, Robert Black, ProfMD, Mathuram Santosham, ProfMD, Katherine L O'Brien, ProfMD, Narendra K Arora, ProfMD   +16 more
doaj   +1 more source

Trends in Meningitis Burden and Projections to 2040: A Secondary Analysis of the Global Burden of Disease Study 2023

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Meningitis remains a global health challenge, characterized by substantial regional and etiologic disparities. This study aimed to analyze recent trends, forecast future burden, and examine the influence of development status on meningitis outcomes.
Mehdi Azizmohammad Looha, Ali Saberi Shahrbabaki, Fatemeh Masaebi, Mahmoud Zamani, Farid Zayeri   +4 more
wiley   +1 more source

Pneumococcal meningitis in children and adults before and after implementation of PCV13 into national pediatric immunization program: A cohort study in Taiwan

Journal of Infection and Public Health
Background: Streptococcus pneumoniae remains a leading cause of bacterial meningitis worldwide. Although pneumococcal conjugate vaccines (PCVs) have markedly reduced vaccine serotypes (VTs) invasive pneumococcal disease, the emergence of non-vaccine ...
Ching-Min Tang, Hsin-Chieh Li, Lin-Hui Su, Jainn-Jim Lin, Shao-Hsuan Hsia, Oi-Wa Chan, En-Pei Lee, Kuang-Lin Lin, Cheng-Hsun Chiu   +8 more
doaj   +1 more source

Perceptions of measles, pneumonia, and meningitis vaccines among caregivers in Shanghai, China, and the health belief model: a cross-sectional study

BMC Pediatrics, 2017
Background In China, the measles vaccine is offered for free whereas the pneumococcal vaccine is a for-fee vaccine. This difference has the potential to influence how caregivers evaluate whether a vaccine is important or necessary for their child, but it
Abram L. Wagner, Matthew L. Boulton, Xiaodong Sun, Bhramar Mukherjee, Zhuoying Huang, Irene A. Harmsen, Jia Ren, Brian J. Zikmund-Fisher   +7 more
doaj   +1 more source

Adjuvant glycerol is not beneficial in experimental pneumococcal meningitis [PDF]

, 2010
Bacterial meningitis in children causes high rates of mortality and morbidity. In a recent clinical trial, oral glycerol significantly reduced severe neurological sequelae in paediatric meningitis caused by Haemophilus influenzae type b, and a tendency ...
Grandgirard, Denis, Blaser, Cornelia, Klein, Matthias, Wittwer, Matthias, Weigand, Michael, Leib, Stephen L., Peltola, Heikki, Koedel, Uwe   +7 more
core   +2 more sources

Progranulin Plays a Protective Role in Pneumococcal Meningitis by Inhibiting Pyroptosis

Immunity, Inflammation and Disease
Objective Pneumococcal meningitis is a serious infectious disease with a high mortality rate and a global presence, and survivors have different degrees of neurological sequelae as a consequence of the host response to the infection.
Jingyao Wang, Lihua Kang, Wenlong Xu, Jiangming Xiao, Yajun Min, Sijie Li, Changlong Zhou, Yibing Yin, Xuemei Zhang, Qun Zhang   +9 more
doaj   +1 more source

Tuberculous meningitis: new tools and new approaches required [version 1; peer review: not peer reviewed] [PDF]

, 2019
Tuberculous meningitis is the most severe form of tuberculosis and causes widespread mortality and morbidity. Understanding of the epidemiology and pathogenesis is incomplete, and the optimal diagnosis and treatment are poorly defined.
Thwaites, Guy, International Tuberculous Meningitis Research Consortium, Seddon, James   +2 more
core   +1 more source

The impact of childhood pneumococcal vaccination on hospital admissions in England: a whole population observational study

BMC Infectious Diseases, 2019
Background Pneumococcal infections are major causes of morbidity and mortality worldwide. We use routine hospital admissions data and time-series modelling analysis to estimate the impact of the seven and thirteen valent pneumococcal conjugate vaccines ...
Tinevimbo Shiri, Noel D. McCarthy, Stavros Petrou   +2 more
doaj   +1 more source

Extracellular calcium reduction strongly increases the lytic capacity of pneumolysin from streptococcus pneumoniae in brain tissue [PDF]

, 2011
Background. Streptococcus pneumoniae causes serious diseases such as pneumonia and meningitis. Its major pathogenic factor is the cholesterol-dependent cytolysin pneumolysin, which produces lytic pores at high concentrations.
Elke Maier, Fortsch, C., Mitchell, T.J., Benz, Roland, Ma, Jiangtao, Christina Förtsch, Sabrina Hupp, Jiangtao Ma, Timothy J. Mitchell, Iliev, A. I., Maier, Elke, Förtsch, Christina, Maier, E., Hupp, Sabrina, Asparouh I. Iliev, Hupp, S., Mitchell, Timothy J, Roland Benz, Wippel, C., Benz, R., Ma, J., Wippel, Carolin, Iliev, Asparouh I, Carolin Wippel   +23 more
core   +1 more source