Results 41 to 50 of about 15,719 (229)

Clinical Outcomes and Treatment Strategies of Adult Transplant‐Associated Thrombotic Microangiopathy: External Validation of Harmonizing Definitions and High‐Risk Criteria

American Journal of Hematology, Volume 100, Issue 5, Page 830-839, May 2025.
ABSTRACT Transplant‐associated thrombotic microangiopathy (TA‐TMA) is an endothelial dysfunction syndrome observed after allogeneic hematopoietic cell transplant (alloHCT). Our aim was to externally validate the impact of high‐risk features on the clinical outcomes of adult patients meeting the updated TA‐TMA harmonizing criteria. Between 2005 and 2022,
Aldo A. Acosta‐Medina, Meera Sridharan, Ronald S. Go, Ann M. Moyer, Nelson Leung, Maria Alice V. Willrich, Robert Wolf, Rabee Kassis, Almothana Manasrah, Mira A. Kohorst, Urshila Durani, Aasiya Matin, Mehrdad Hefazi, Saad J. Kenderian, Abhishek A. Mangaonkar, Mithun V. Shah, Mark R. Litzow, William J. Hogan, David Dingli, Hassan B. Alkhateeb   +19 more
wiley   +1 more source

Meningococcal vaccine. From capsular polysaccharides of microbes to proteases

RUDN Journal of Medicine, 2012
Microbial capsular polysaccharides for many years provided a highly practical public health vaccines for preventing meningococcal, pneumococcal and Haemophilus influenza infection, and typhoid fever.
A P Alliluyev, I V Anokhina, L D Rumsh, E E Melnikov, O V Kotelnikova, E A Sitnikova, E J Drozzina, L S Zhigis, E J Yagudayeva, O A Razgulyaeva, V S Zueva, L V Kozlov, A E Avakov   +12 more
doaj  

Fatal meningococcal meningitis in a HIV-infected patient caused by serogroup C Neisseria meningitidis belonging to the non-hypervirulent clonal complex ST-60 (cc60)

Brazilian Journal of Infectious Diseases
Meningococcal strains belonging to clonal complex cc60 are not associated with hypervirulent lineages and were never reported as causing disease in Latin American countries.
Claudia Ferreira de Andrade, Denise Cotrim da Cunha, Veronica Cavalcanti, Ivano de Filippis   +3 more
doaj   +1 more source

The human host defense peptide LL-37 interacts with Neisseria meningitidis capsular polysaccharides and inhibits inflammatory mediators release. [PDF]

PLoS ONE, 2010
Capsular polysaccharides (CPS) are a major virulence factor in meningococcal infections and form the basis for serogroup designation and protective vaccines.
Susu M Zughaier, Pavel Svoboda, Jan Pohl, David S Stephens, William M Shafer   +4 more
doaj   +1 more source

Beta‐Lactam Antibiotics Promote Extracellular Vesicle Production of Staphylococcus aureus Through ROS‐Mediated Lipid Metabolic Reprogramming

Journal of Extracellular Vesicles, Volume 14, Issue 5, May 2025.
ABSTRACT Bacterial extracellular vesicles (EVs) are natural reservoirs of biological active substances. They exhibit promising application in developing bioproducts such as vaccine, drug‐delivery system and anticancer agent. However, the low yield of naturally secreted EVs during bacterial growth is a bottleneck factor that restricts EV applications ...
Xiaonan Huang, Zhen Hu, Weilong Shang, Juan Chen, Qiwen Hu, Yumin Zhou, Ruolan Ding, Jing Yin, Mengyang Li, He Liu, Jianxiong Dou, Huagang Peng, Yifan Rao, Lu Liu, Yuting Wang, Li Tan, Yuhua Yang, Jianghong Wu, Chuan Xiao, Yi Yang, Xiancai Rao   +20 more
wiley   +1 more source

The Meningococcal Cysteine Transport System Plays a Crucial Role in Neisseria meningitidis Survival in Human Brain Microvascular Endothelial Cells

mBio, 2018
While Neisseria meningitidis typically exists in an asymptomatic nasopharyngeal carriage state, it may cause potentially lethal diseases in humans, such as septicemia or meningitis, by invading deeper sites in the body. Since the nutrient compositions of
Hideyuki Takahashi, Haruo Watanabe, Kwang Sik Kim, Shigeyuki Yokoyama, Tatsuo Yanagisawa   +4 more
doaj   +1 more source

Development of a Recombinant Outer Membrane Vesicles (OMVs)‐Based Vaccine Against Helicobacter pylori Infection in Mice

Journal of Extracellular Vesicles, Volume 14, Issue 5, May 2025.
This study innovatively modified the structure of LPS for the recombinant H. pylori OMV vaccine, and utilised the vector advantage of OMVs to deliver the H. pylori main antigen proteins UreB, VacA and CagA to exert the synergistic effect of the vaccine, providing a new strategy for the design of H.
Qiong Liu, Biaoxian Li, Jinrong Ma, Xiao Lei, Junpeng Ma, Yanyan Da, Zhiyong Zhou, Jiaqi Tao, Xinyi Ren, Ting Zeng, Zhiting Xie, Haiyan Lin, Zihui Jin, Yi Wan, Liang Zhang, Donglin Lai, Yaping Guo, Jing Li, Yinpan Shang, Lu Shen, Ziwei Tao, Tian Gong, Chengsheng Zhang   +22 more
wiley   +1 more source

Increased incidence of Neisseria meningitidis infections in Nuevo León, Mexico

Salud Pública de México, 2020
[Not available]
María Teresa Ramírez-Elizondo, Elvira Garza-González, Gabriela Echániz-Aviles, Samantha Flores-Treviño, María Noemí Carnalla-Barajas, Adrián Camacho-Ortiz   +5 more
doaj   +1 more source

Meningococcal Carriage in ‘Men Having Sex With Men’ With Pharyngeal Gonorrhoea

Frontiers in Cellular and Infection Microbiology, 2022
We assessed the characteristics of Neisseria meningitidis pharyngeal carriage in a cohort of ‘men having sex with men’, including patients with pharyngeal Neisseria gonorrhoeae infection.
Sara Morselli, Valeria Gaspari, Alessia Cantiani, Melissa Salvo, Claudio Foschi, Tiziana Lazzarotto, Antonella Marangoni   +6 more
doaj   +1 more source

Childhood Vaccine Hesitancy as an Interaction‐Based Phenomenon

Sociology of Health &Illness, Volume 47, Issue 4, May 2025.
ABSTRACT The paper discusses the role of the interaction between parents and healthcare professionals in overcoming or heightening childhood vaccine hesitancy. Childhood vaccine hesitancy is seen as a set of attitudes and behaviours—that is, dispositions—that are highly dependent on how trust and vulnerability intersect during vaccination appointments.
Alice Scavarda, Mario Cardano, Luigi Gariglio   +2 more
wiley   +1 more source