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The Menopausal Transition

Obstetrics and Gynecology Clinics of North America, 2017
A clear understanding of the physiology of the menopausal transition, clinical symptoms, and physical changes is essential for individualized patient management, maximizing benefits and minimizing risks for the present and the future. Menopause, defined by amenorrhea for 12 consecutive months, is determined retrospectively and represents a permanent ...
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The menopausal transition

The American Journal of Medicine, 2005
Reproductive aging in women is related to the depletion of a fixed number of germ cells within the ovary. Prenatally, almost 50% of the maximal follicle pool is lost. Thereafter, atresia slows until women reach their early 40s, when total remaining follicle numbers reach a critical threshold.
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Ovarian ageing and the menopausal transition

Best Practice & Research Clinical Obstetrics & Gynaecology, 2002
The underlying cause of the menopausal transition is a dwindling supply of FSH-responsive follicles available for ovulation. Additional factors may include dysregulation of existing follicles and concurrent follicle and oocyte deficits that may be strictly anatomic or consequences of the hormonal milieu.
Gregory, Zapantis, Nanette, Santoro
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Menopause transition: Physiology and symptoms

Best Practice & Research Clinical Obstetrics & Gynaecology, 2022
With life expectancy for women on the rise, most women will experience menopausal transition and spend a significant number of years of their life in the menopausal phase. Menopausal transition involves a myriad of physical, endocrine, and psychological changes which are influenced by ethnic, psychological, and socio-cultural factors.
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Menopausal transition and psychological development

Menopause, 2003
To study women's psychological development during menopause and to examine the relationship between women's appraisal of menopause and symptom reporting.A population-based sample of 130 healthy women was assessed annually for 5 consecutive years using semistructured interviews, a menopausal symptom rating scale, and the Symptom Checklist-90 rating ...
H, Busch   +3 more
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The Menopausal Transition: Guidelines for Researchers

Health Education, 1989
We believe that the menopausal transition can be eased for women if they have information about normal changes they can anticipate. Until now, research on the subject of menopause has been fragmented and flawed, in large part because an "oppositional approach" to the study of menopause has pitted biology against culture and has slowed progress toward a
Mansfield, Phyliss Kernoff   +2 more
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Defining the menopausal transition

The American Journal of Medicine, 2005
Menopause signifies the permanent cessation of ovarian function and the end of a woman's reproductive potential. A universal experience in women's aging, it is the culmination of some 50 years of reproductive aging--a process that unfolds as a continuum from birth through ovarian senescence to the menopausal transition and the postmenopause.
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The menopausal transition: characteristics and management

Best Practice & Research Clinical Endocrinology & Metabolism, 2003
The menopausal transition is a complex period in a woman's life, reflecting ovarian ageing and concomitant hormonal changes, in addition to social and metabolic changes. These changes, in turn, influence the signs and symptoms common to this period. Symptoms which are influenced by the hormonal fluctuations occurring during the menopausal transition ...
Gregory, Zapantis, Nanette, Santoro
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Migraine, hormones and the menopausal transition

Climacteric, 2018
Migraine is a common, disabling and incapacitating headache disorder that may be triggered by many factors, such as hormones especially during the perimenopausal period, where large alterations in estradiol levels can occur. The evidence implies that hormonal fluctuations are one of the important triggers of migraine.
M A, Hipolito Rodrigues   +3 more
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Depressive disorders and the menopause transition

Maturitas, 2012
Depressive disorders and symptoms are common among middle-aged women. The effects of hormones on depression remain unclear. This review aims to clarify the nature of depressive disorders during the menopause transition as well as their links with climacteric syndrome, sexuality, cardiovascular risk and cognitive function.The recent literature on ...
Plácido, Llaneza   +4 more
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