Results 71 to 80 of about 4,816,387 (353)

Exploring Comorbidity Within Mental Disorders Among a Danish National Population

JAMA psychiatry, 2019
Importance Individuals with mental disorders often develop comorbidity over time. Past studies of comorbidity have often restricted analyses to a subset of disorders and few studies have provided absolute risks of later comorbidity.
O. Plana-Ripoll, C. Pedersen, Y. Holtz, M. Benros, S. Dalsgaard, P. de Jonge, C. Fan, L. Degenhardt, Andrea Ganna, A. Greve, J. Gunn, K. Iburg, L. Kessing, Brian K. Lee, C. Lim, O. Mors, M. Nordentoft, Anders Prior, A. Roest, S. Saha, A. Schork, James G. Scott, K. Scott, T. Stedman, H. Sørensen, T. Werge, H. Whiteford, T. Laursen, E. Agerbo, R. Kessler, P. Mortensen, J. Mcgrath   +31 more
semanticscholar   +1 more source

Timing and Predictive Value of Clinical Conditions Preceding Multiple Sclerosis in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Multiple sclerosis (MS) patients often experience a higher incidence of clinical conditions before diagnosis, suggesting a prodromal phase. However, their predictive value and temporal trajectories remain underexplored. We investigated these aspects using the large UK Biobank's population‐based cohort, which provided clinical ...
Andrea Nova, Teresa Fazia, Giovanni Di Caprio, Davide Gentilini, Luisa Bernardinelli, Roberto Bergamaschi   +5 more
wiley   +1 more source

The Chinese version of the immediate mood scaler (IMS): a study evaluating its validity, reliability, and responsiveness in patients with MDD in China

BMC Psychiatry
Background It is important to timely capture the fluctuation of the symptoms related to major depressive disorder (MDD). However, most conventionally used assessment tools for MDD symptoms are not designed for real-time assessment.
Xiongying Chen, Zizhao Feng, Nanxi Li, Le Xiao, Xu Chen, Xuequan Zhu   +5 more
doaj   +1 more source

Altered Cerebro-Cerebellar Functional Connectivity Associated With Working Memory Decline After Sleep Deprivation

Journal of Integrative Neuroscience
Background: It has been demonstrated that the cerebellum plays a critical role not only in motor function but also in cognitive function.
Ziyao Wu, Sitong Feng, Sisi Zheng, Linrui Dong, Hongxiao Jia, Yanzhe Ning   +5 more
doaj   +1 more source

Digital Activity Markers in Chronic Inflammatory Demyelinating Polyneuropathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the utility of smartwatch and smartphone‐based activity metrics for assessing disease severity and quality of life in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). Methods In the electronic monitoring of disease activity in patients with CIDP (EMDA‐CIDP) trial, we performed a prospective ...
Lars Masanneck, Jan Voth, Noëmi Gmahl, Konstantin Jendretzky, Niklas Huntemann, Noah M. Werner, Linea Schmidt, Menekse Oeztuerk, Paula Quint, Christina B. Schroeter, Hans Peter Hartung, Thomas Skripuletz, Gerd Meyer zu Hörste, Tobias Ruck, Sven G. Meuth, Marc Pawlitzki   +15 more
wiley   +1 more source

Clinical characteristics of 217 Chinese cases with depersonalization/derealization disorder

BMC Psychiatry
Depersonalization/derealization disorder (DPD) is a prevalent yet inadequately understood clinical condition characterized by a recurrent or persistent sense of unreality.
Mingkang Song, Sisi Zheng, Nan Song, Hong Zhu, Yuan Jia, Zhiqing Dai, Xinzi Liu, Ziyao Wu, Yuhang Duan, Zhiyuan Huang, Jindong Chen, Hongxiao Jia   +11 more
doaj   +1 more source

Prevalence, severity, and unmet need for treatment of mental disorders in the World Health Organization World Mental Health Surveys.

Journal of the American Medical Association (JAMA), 2004
CONTEXT Little is known about the extent or severity of untreated mental disorders, especially in less-developed countries. OBJECTIVE To estimate prevalence, severity, and treatment of Diagnostic and Statistical Manual of Mental Disorders, Fourth ...
K. Demyttenaere, R. Bruffaerts, J. Posada-Villa, I. Gasquet, V. Kovess, J. Lépine, M. Angermeyer, S. Bernert, G. de Girolamo, P. Morosini, G. Polidori, T. Kikkawa, N. Kawakami, Y. Ono, T. Takeshima, H. Uda, E. Karam, J. Fayyad, A. Karam, Z. Mneimneh, M. Medina-Mora, G. Borges, C. Lara, R. de Graaf, J. Ormel, O. Gureje, Yu-cun Shen, Yueqin Huang, Mingyuan Zhang, J. Alonso, J. Haro, G. Vilagut, E. Bromet, S. Gluzman, Charles P M Webb, R. Kessler, K. Merikangas, J. Anthony, M. Von Korff, Philip S. Wang, T. Brugha, S. Aguilar-Gaxiola, Sing Lee, S. Heeringa, B. Pennell, A. Zaslavsky, T. Ustun, S. Chatterji   +47 more
semanticscholar   +1 more source

Cognitive Resilience in Apolipoprotein ε4 Carrier Women Predicted by Neuron‐Derived Extracellular Vesicles

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Apolipoprotein (APOE) ε4 allele is the strongest genetic risk factor for late‐onset Alzheimer's disease (AD); however, many ε4 carriers remain cognitively intact into old age. Leveraging plasma neuron‐derived extracellular vesicles (NDEVs), we sought to identify biomarkers of cognitive resilience and their interplay with APOE ...
Apostolos Manolopoulos, Maja Mustapic, Carlos Nogueras‐Ortiz, Francheska Delgado‐Peraza, Krishna A. Pucha, Pamela J. Yao, Joseph Blommer, Michael P. Vreones, William York, De' Larrian Knight, Stephen R. Rapp, Aladdin H. Shadyab, JoAnn E. Manson, Ramon Casanova, Robert B. Wallace, Luigi Ferrucci, Susan M. Resnick, Dimitrios Kapogiannis   +17 more
wiley   +1 more source

LC–MS/MS quantification of 20(S)-protopanaxadiol in complex biological matrices for bioanalytical method validation and pharmacokinetic analysis

Scientific Reports
20(S)-Protopanaxadiol (PPD) is a saponin derivative of ginsenoside, with more potent biological and pharmacological activities than Rg3 and Rh2. The lack of ionizable centers leads to low mass spectrometry reactions and internal cleavage of three ...
Pengfei Li, Shanshan Liu, Hongyan Zhuang, Mengxi niu, Fei Pan, Nan Wang, Sha Sha, Qian Wang, Jing Wang   +8 more
doaj   +1 more source

Effects of Pharmacologic and Nonpharmacologic Interventions for the Management of Sleep Problems in People With Fibromyalgia: Systematic Review and Network Meta‐Analysis of Randomized Controlled Trials

Arthritis Care &Research, EarlyView.
Objective Fibromyalgia is a chronic condition characterized by widespread musculoskeletal pain and fatigue. Almost everyone with fibromyalgia has sleep problems. We aimed to evaluate the effectiveness and safety of current interventions for the management of fibromyalgia‐related sleep problems.
Jemma Hudson, Mari Imamura, Clare Robertson, Daniel Whibley, Lorna Aucott, Katie Gillies, Paul Manson, Debra Dulake, Abhishek Abhishek, Nicole K. Y. Tang, Gary J. Macfarlane, Miriam Brazzelli   +11 more
wiley   +1 more source