Results 11 to 20 of about 2,618,764 (254)
Frontiers in Behavioral Neuroscience, 2022 In preclinical psychiatry research, animals are central to modeling and understanding biological mechanisms of behavior and psychiatric disorders. We here present the first multimodal severity assessment of a genetically modified rat strain used in ...
Anne Stephanie Mallien +15 more
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Genome wide association study identifies four loci for early onset schizophrenia
Translational Psychiatry, 2021 Early onset schizophrenia (EOS, defined as first onset of schizophrenia before age 18) is a rare form of schizophrenia (SCZ). Though genome-wide association studies (GWASs) have identified multiple risk variants for SCZ, most of the cases included in ...
Suqin Guo +8 more
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BMC Medicine, 2021 Background Over 200 schizophrenia risk loci have been identified by genome-wide association studies (GWASs). However, the majority of risk loci were identified in populations of European ancestry (EUR), potentially missing important biological insights ...
Jiewei Liu +11 more
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Bidirectional genetic overlap between bipolar disorder and intelligence
BMC Medicine, 2022 Background Bipolar disorder (BD) is a highly heritable psychiatric illness exhibiting substantial correlation with intelligence. Methods To investigate the shared genetic signatures between BD and intelligence, we utilized the summary statistics from ...
Meng-Yuan Shang +8 more
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Transcriptome-wide association study identifies new susceptibility genes and pathways for depression
Translational Psychiatry, 2021 Depression is the most prevalent mental disorder with substantial morbidity and mortality. Although genome-wide association studies (GWASs) have identified multiple risk variants for depression, due to the complicated gene regulatory mechanisms and ...
Xiaoyan Li +7 more
doaj +1 more source
The schizophrenia-associated missense variant rs13107325 regulates dendritic spine density
Translational Psychiatry, 2022 The missense variant rs13107325 (C/T, p.Ala391Thr) in SLC39A8 consistently showed robust association with schizophrenia in recent genome-wide association studies (GWASs), suggesting the potential pathogenicity of this non-synonymous risk variant ...
Shiwu Li +15 more
doaj +1 more source
Robot Models of Mental Disorders [PDF]
, 2017 Alongside technological tools to support wellbeing and treatment of mental disorders, models of these disorders can also be invaluable tools to understand, support and improve these conditions.
Cañamero, Lola, Lewis, Matthew
core +2 more sources
Understanding inter-organizational decision coordination [PDF]
, 2010 This article develops a theoretical framework to investigate the interaction and coordination of decision-making processes in a supply chain with multiple and inter-dependent suppliers and customers.
Acur, Nuran +2 more
core +1 more source
Consensus Emerging from the Bottom-up: the Role of Cognitive Variables in Opinion Dynamics [PDF]
, 2015 The study of opinions $-$ e.g., their formation and change, and their effects on our society $-$ by means of theoretical and numerical models has been one of the main goals of sociophysics until now, but it is one of the defining topics addressed by ...
Conte, Rosaria +2 more
core +3 more sources
Perinatal Hypoxia and Ischemia in Animal Models of Schizophrenia
Frontiers in Psychiatry, 2018 Intrauterine or perinatal complications constitute a major risk for psychiatric diseases. Infants who suffered from hypoxia–ischemia (HI) are at twofold risk to develop schizophrenia in later life.
Dimitri Hefter +5 more
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