Results 201 to 210 of about 19,895 (301)

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Mentalization in Asylum Seekers with Post-Traumatic Stress Disorder. [PDF]

Int J Environ Res Public Health
Aragona M, Cavallo M, Ferrari F, Laurendi G, Nicolella G.   +4 more
europepmc   +1 more source

Bioinspired Hierarchical Architecture with Water Transport Channels for Strong Adhesion at the Sweating Interface

Advanced Science, EarlyView.
To address adhesion failure in sweaty epidermal electronics, this study proposes a cross‐species, multi‐scale biomimetic interface. By modeling staged wet adhesion, it integrates self‐regulating liquid bridges with directional drainage. This design ensures stable, high‐performance flexible sensing in complex physiological environments, offering a ...
Jieliang Zhao, Yu Xiang, Heng Wang, Huiqing Xu, Zhong Liu, Lulu Liang, Fengwen Jiang, Xuemei Chen, Wenzhong Wang, Chenqing Liu, Guodong Liu, Shaoze Yan, Xu Hou   +12 more
wiley   +1 more source

A transdiagnostic mentalization-based parenting intervention versus care as usual for parents with mental disorders in adult mental health services in Denmark: protocol for a randomized clinical trial. [PDF]

Trials
Hestbaek E, Væver MS, Juul S, Sørensen P, Sleed M, Simonsen S.   +5 more
europepmc   +1 more source

Endometrial Epithelial Lactate Deficiency Drives CD8+ T‐Cells Dysregulation in Unexplained Recurrent Implantation Failure

Advanced Science, EarlyView.
Unexplained recurrent implantation failure (RIF) represents a significant clinical challenge. Our results demonstrate that reduced lactate production in the RIF endometrium impairs the suppression of cytotoxic CD8+ T‑cells, allowing their proliferation and thereby disrupting the local immune balance essential for successful embryo implantation.
Yuanlin He, Kang Ke, Qingxia Meng, Yichun Guan, Jichun Tan, Hong Lv, Boxian Huang, Chan Tian, Qinyan Zou, Mingxing An, Yao Gao, Jingjing Chen, Xiaoyu Wei, Xi Wang, Hongxia Ma, Yuan Lin, Feiyang Diao, Yayun Gu, Zhibin Hu   +18 more
wiley   +1 more source

Effectiveness of mentalization-based therapy and dialectical behavior therapy for cluster B personality disorders: a naturalistic study of service utilization and treatment dropout. [PDF]

Front Psychiatry
Yin P, Poirier S, Allary A, Pérusse F, David P, Lahaie FS, Cailhol L.   +6 more
europepmc   +1 more source

The Care of the Soul and Treatments for Sufferers of Borderline Personality Disorder [PDF]

, 2014
Calvert-Koyzis, Nancy
core   +1 more source

Stable Diffusion Models Reveal a Persisting Human–AI Gap in Visual Creativity

Advanced Science, EarlyView.
This study examines visual creativity in humans and generative AI using the TCIA framework. Human artists outperform AI overall, yet structured human guidance substantially improves AI outputs and evaluations. Findings reveal that alignment with human creativity depends critically on contextual framing, highlighting both the promise and current ...
Silvia Rondini, Claudia Alvarez‐Martin, Paula Angermair‐Barkai, Olivier Penacchio, Marc Paz, Matthew Pelowski, Dan Dediu, Antoni Rodriguez‐Fornells, Xim Cerda‐Company   +8 more
wiley   +1 more source

Validation of the Mentalization Scale (MentS) in francophone control and clinical samples. [PDF]

PLoS One
Descartes F, Besch V, Bouteloup M, Nicastro R, Pham E, Rüfenacht E, Perroud NA, Debbané M.   +7 more
europepmc   +1 more source

Ethical Precision in Nanoscale Brain Interfacing

Advanced Science, EarlyView.
As brain interfaces approach the nanoscale, precision no longer only measures—it knows, predicts, and potentially reshapes the mind. This work argues that traditional ethics fails under such conditions and proposes a shift toward continuous, operation‐based governance using the recovery–discovery framework to track, constrain, and responsibly steer ...
Guilherme Wood
wiley   +1 more source