Measuring young adult appeal for menthol and non-menthol cigarettes: protocol of a clinical trial using both laboratory and intensive longitudinal methods (PRISM) [PDF]
BMJ Open, 2022 Introduction Although the Food and Drug Administration banned other characterising flavours in cigarettes, menthol cigarettes are still available to consumers.
Michael Smith +11 more
doaj +2 more sources
Ca2+-independent cytotoxicity of menthol in the A549 lung cancer cell line [PDF]
Current Research in ToxicologyMenthol evokes cooling sensations by activating the transient receptor potential melastatin 8 (TRPM8) channel, resulting in relaxing, anti-inflammatory, and analgesic effects when administered through inhalation and topical application.
Kenji Takahashi, Toshio Ohta
doaj +2 more sources
Menthol stereoisomers exhibit different effects on α4β2 nAChR upregulation and dopamine neuron spontaneous firing [PDF]
, 2018 Menthol contributes to poor cessation rates among smokers, in part because menthol enhances nicotine reward and reinforcement. Mentholated tobacco products contain (−)-menthol and (+)-menthol, in varying proportions.
Chu, Betty W. +8 more
core +5 more sources
Molecular mechanisms underlying menthol binding and activation of TRPM8 ion channel
Nature Communications, 2020 Menthol in mints elicits a coolness sensation by selective activation of TRPM8 ion channel. Here authors dock menthol to TRPM8 and systematically validate their menthol binding models with thermodynamic mutant cycle analysis in functional tests, and shed
Xiaoying Chen, Han Wen, Wenjun Zheng
exaly +2 more sources
A TRP Channel that Senses Cold Stimuli and Menthol [PDF]
Cell, 2002 Aziz Moqrich +2 more
exaly +2 more sources
Exclusive and dual menthol/non-menthol cigarette use with ENDS among adults, 2013–2019
Preventive Medicine Reports, 2021 This study examines patterns of use for menthol/non-menthol cigarettes and Electronic Nicotine Delivery Systems (ENDS) from 2013 to 2019 among U.S. adults.
Bukola Usidame +7 more
doaj +1 more source
Impact of a reduced nicotine standard on young adult appeal for menthol and non-menthol cigarettes
BMJ Open, 2022 Introduction The Food and Drug Administration (FDA) announced its intention to reduce the nicotine content in cigarettes as a strategy to promote cessation and reduce smoking-related harm.
Michael Smith +11 more
doaj +1 more source
Preventive Medicine Reports, 2023 The US Food and Drug Administration is considering banning menthol cigarettes, which could result in some people who smoke menthol cigarettes switching to other tobacco products (OTPs).
Rachel L. Denlinger-Apte +7 more
doaj +1 more source
Menthol binding and inhibition of α7-nicotinic acetylcholine receptors. [PDF]
PLoS ONE, 2013 Menthol is a common compound in pharmaceutical and commercial products and a popular additive to cigarettes. The molecular targets of menthol remain poorly defined.
Abrar Ashoor +11 more
doaj +1 more source
Frontiers in Pharmacology, 2022 This secondary analysis sought to determine if plasma menthol glucuronide (MG) concentrations predict changes in three outcomes, subjective drug effects, urges to smoke, and heart rate, following concurrent inhaled menthol and intravenous nicotine.
Ralitza Gueorguieva +11 more
doaj +1 more source