Results 91 to 100 of about 8,451 (198)

Correlation of Local Nasal Biomarkers and Olfactory Dysfunction in Chronic Rhinosinusitis: A Systematic Review and Meta‐Analysis

International Forum of Allergy &Rhinology, Volume 16, Issue 9, Page 1012-1023, September 2026.
ABSTRACT Background To systematically evaluate the local biomarkers correlated with olfactory dysfunction (OD) in chronic rhinosinusitis (CRS). Methods A systematic review was conducted in CINAHL, Cochrane Library, PubMed, and Scopus from inception to July 2025.
David Kayekjian, Neeti Gandra, Shaun A. Nguyen, Shaina W. Twardus, Rodney J. Schlosser   +4 more
wiley   +1 more source

Mepolizumab treatment in patients with severe eosinophilic asthma. [PDF]

, 2014
BACKGROUND: Some patients with severe asthma have frequent exacerbations associated with persistent eosinophilic inflammation despite continuous treatment with high-dose inhaled glucocorticoids with or without oral glucocorticoids.
Pavord, Ian D., Oliver N. Keene, Yancey, Steven W., Brusselle, Guy G., Liu, MC, Chanez, P, Liu, Mark C, Brusselle, GG, Humbert, M, FitzGerald, J. Mark, Hector G. Ortega, FitzGerald, J Mark, Ian D. Pavord, Pavord, ID, Marc Humbert, Katz, LE, Chanez, Pascal, Steven W. Yancey, Katz, Lynn E, J. Mark FitzGerald, Yancey, Steven W, Mark C. Liu, Guy G. Brusselle, Chetta, Alfredo, Humbert, Marc, Keene, ON, Lynn E. Katz, FitzGerald, JM, Ortega, Hector G., Keene, Oliver N., Keene, Oliver N, Ortega, HG, Pascal Chanez, CANONICA, GIORGIO, CHETTA, Alfredo Antonio, Ortega, Hector G, Liu, Mark C., Brusselle, Guy, Chetta, A, Brusselle, Guy G, Pavord, Ian D, Katz, Lynn E., Yancey, SW   +42 more
core   +1 more source

Artificial Intelligence Resources for the Screening of Titles and Abstracts in Systematic Reviews: A Scoping Review

Cochrane Evidence Synthesis and Methods, Volume 4, Issue 5, September 2026.
ABSTRACT Introduction Artificial intelligence (AI) is a branch of technology enabling machines to emulate complex human skills; it can also entail problem‐solving using bioinspired methods. It is used for automating systematic literature reviews (SLR), that is, defining a clinical question, locating relevant literature, preliminary screening, study ...
Ana M. Barragán, Sara Elena Ortiz Bonett, Eliana‐Isabel Rodríguez‐Grande, Alvaro David Orjuela‐Cañón, Oscar J. Perdomo, Guillermo Sánchez‐Vanegas   +5 more
wiley   +1 more source

Patient profiles and clinical utility of mepolizumab in severe eosinophilic asthma [PDF]

, 2017
Pranabashis Haldar Respiratory Biomedical Research Unit, Glenfield Hospital, University of Leicester, Leicester, UK Abstract: Mepolizumab (Nucala®) is an effective and specific anti-eosinophil molecular therapy that has recently been approved as add ...
Pranabashis Haldar, Pranabashis Haldar (615722), Haldar P   +2 more
core   +1 more source

Efficacy of mepolizumab and omalizumab combination therapy in uncontrolled asthma

, 2023
ObjectiveResults of biological therapies are often encouraging for severe asthma who are phenotyped as Type 2 inflammation. Unfortunately, some patients do not achieve the desired responses.
Fuat Erel, Mustafa Çolak, Aktepe Sezgin, Esma Nur, Esma Nur Aktepe Sezgin, Bilun Gemicioğlu, Özge Çağlayan, Çolak, Mustafa, Sarıoğlu, Nurhan, Mehmet Emin Sezgin, Yumrukuz Şenel, Merve, Merve Yumrukuz Şenel, Çoban, Hikmet, Sezgin, Mehmet Emin, Nurhan Sarıoğlu, Çağlayan, Özge, Erel, Fuat, Gemicioğlu, BİLUN, Hikmet Çoban   +17 more
core   +1 more source

Phenotypic Clusters of Severe Asthma and Response to Dupilumab in Real‐World Practice

Clinical and Translational Allergy, Volume 16, Issue 9, September 2026.
ABSTRACT Background Severe asthma is a heterogeneous disease with variable clinical and inflammatory profiles that may influence responses to biological therapies. Identifying phenotypic clusters may help optimize patient selection and treatment outcomes.
Daria S. Fomina, Sergey V. Fedosenko, Аnton А. Chernov, Elena N. Bobrikova, Оlga А. Mukhina, Marina S. Lebedkina, Alexander V. Karaulov, Asel Yu. Nurtazina, Mariana A. Lysenko, Harald Renz   +9 more
wiley   +1 more source

Ratio of plasma IL-13/TNF- ∝ and CXCL10/CCL17 predicts mepolizumab and omalizumab response in asthma better than eosinophil count or immunoglobulin E level

Scientific Reports
To date, most studies to identify biomarkers associated with response to the anti-interleukin 5 agent, mepolizumab, and to the anti-immunoglobulin E agent, omalizumab have focused on clinically available biomarkers, such as the peripheral blood ...
Ayobami Akenroye, Tanawin Nopsopon, Jonathan J. Hacker, Tanya M. Laidlaw   +3 more
doaj   +1 more source

Real-World Effectiveness of Mepolizumab in Patients with Severe Asthma: An Examination of Exacerbations and Costs

Journal of Asthma and Allergy, 2020
Jean-Pierre Llanos,1 Hector Ortega,1 Michael Bogart,2 Elizabeth R Packnett,3 Janna Manjelievskaia,3 Christopher F Bell,2 Beth Hahn2 1Respiratory, US Medical Affairs, GSK, Research Triangle Park, NC, USA; 2US Value Evidence and Outcomes, US Medical ...
Llanos JP, Ortega H, Bogart M, Packnett ER, Manjelievskaia J, Bell CF, Hahn B   +6 more
doaj  

Recurrent Asthma Exacerbations Secondary to Gastric Stenosis After Gastric Band Slippage: Case Report and Literature Review

Respirology Case Reports, Volume 14, Issue 9, September 2026.
We present a patient with long‐standing severe Type 2 asthma complicated by recurrent exacerbations of an infective nature that was ultimately found to be associated with gastric band slippage causing gastric stenosis and delayed gastric emptying. Exacerbations ceased after surgical intervention and removal of the band.
Gerardo Arwi, Adriana Avram, Philip Bardin   +2 more
wiley   +1 more source

The Effect of Mepolizumab on Blood Eosinophil Subtype Distribution and Granule Protein Gene Expression in Severe Eosinophilic Asthma [PDF]

Airidas Rimkunas,1 Andrius Januskevicius,1 Egle Vasyle,1 Jolita Palacionyte,2 Virginija Kalinauskaite-Zukauske,2 Skaidrius Miliauskas,2 Kestutis Malakauskas1,2 1Laboratory of Pulmonology, Department of Pulmonology, Lithuanian University of Health ...
Palacionyte J, Rimkunas A, Vasyle E, Malakauskas K, Miliauskas S, Kalinauskaite-Zukauske V, Januskevicius A   +6 more
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