Results 111 to 120 of about 8,451 (198)

Update on Pediatric asthma management: Recent advances

Pediatric Allergy and Immunology, Volume 37, Issue 9, September 2026.
Pathophysiology of asthma: an opportunity for personalized targeted therapeutics. Abstract Asthma remains the commonest chronic pediatric respiratory disease and a major cause of childhood morbidity worldwide. Recent advances in pediatric asthma management shift the focus from symptom relief alone towards early control of airway inflammation ...
Nitin Dhochak, Polly F. M. Robinson, Sejal Saglani   +2 more
wiley   +1 more source

Real-world impact of mepolizumab on pediatric and adolescent patients with severe asthma

Journal of Allergy and Clinical Immunology: Global
Background: Real-world evidence on the effectiveness of mepolizumab in children and adolescents with severe asthma (SA) is limited. Objective: We sought to evaluate mepolizumab’s impact on the clinical and health care resource utilization (HCRU) burden ...
Michelle L. Hernandez, MD, Tom Corbridge, MD, François Laliberté, MA, Malena Mahendran, MSc, Annalise Hilts, BA, Kaixin Zhang, MSc, Arijita Deb, PhD   +6 more
doaj   +1 more source

Revisiting CD8+ T Cells in Allergy: The Emerging Role of Tc2 Cells

Scandinavian Journal of Immunology, Volume 104, Issue 3, September 2026.
Tc2 CD8+ T cells in Type 2 inflammation: induction, tissue adaptation, metabolic programming, and therapeutic implications. Both naïve CD8+ T cells and pre‐committed Tc1 CD8+ T cells can be directed towards a Tc2 phenotype, characterised by secretion of the Type 2 cytokines IL‐4, IL‐5, IL‐9 and IL‐13, which in turn drive eosinophil recruitment, goblet ...
Sabrina de Souza Ferreira, Christopher Andrew Tibbitt   +1 more
wiley   +1 more source

Mepolizumab [PDF]

Reactions Weekly, 2020
openaire   +2 more sources

Differential Effects of Benralizumab and Mepolizumab on Pro‐Resolving Mediators

Allergy, Volume 81, Issue 9, Page 3377-3383, September 2026.
Jaime Bernaola, José Antonio Cañas, Álvaro Arranz‐Fragua, José Manuel Rodrigo‐Muñoz, Daniel Rodríguez‐González, Antonio Serrano‐Santiago, Gema Guillén‐Sánchez, Alma Martínez Fernández, Marcela Valverde‐Monge, Diana Betancor, Erwin Javier Pinillos‐Robles, Claudia Rodríguez‐Busto, María Jesús Rodríguez‐Nieto, Joaquín Sastre, Victoria del Pozo   +14 more
wiley   +1 more source

Improved long-term prognosis of eosinophilic granulomatosis with polyangiitis: retrospective analysis of 87 patients after biologic therapy introduction in Japan

Scientific Reports
Five-year survival in eosinophilic granulomatosis with polyangiitis (EGPA) exceeds 90%, but long-term prognosis is poor. We examined prognosis in 87 Japanese EGPA patients, seen between April 2018 and December 2024, after mepolizumab introduction ...
Yuga Yamashita, Nami Masumoto, Sachiko Takaoka, Takuya Nakashima, Kaho Matsunaga, Yuka Kodama, Kosuke Terada, Hinako Masumitsu, Atsushi Miyasaka, Tatsuya Muraoka, Takeshi Kaneko, Naomi Tsurikisawa   +11 more
doaj   +1 more source

Real-World Reductions in Oral Corticosteroid Use in the USA Following Mepolizumab Therapy for Severe Asthma

Journal of Asthma and Allergy, 2020
Jared Silver,1 Michael Bogart,1 Elizabeth Packnett,2 Juan Wu,2 Donna McMorrow,2 Beth Hahn1 1US Medical Affairs, GSK, Research Triangle Park, NC, USA; 2Life Sciences, IBM Watson Health, Bethesda, MD, USACorrespondence: Beth Hahn Email beth.a.hahn@gsk ...
Silver J, Bogart M, Packnett E, Wu J, McMorrow D, Hahn B   +5 more
doaj  

Serum Eosinophil‐Derived Neurotoxin (EDN) as a Biomarker for Treatment Response in Atopic Dermatitis

Clinical &Experimental Allergy, Volume 56, Issue 9, Page 1084-1086, September 2026.
J. I. Olydam, S. Sengkerij, S. Veenbergen, D. J. Hijnen   +3 more
wiley   +1 more source

Mepolizumab for the management of chronic rhinosinusitis with nasal polyps across the United States: A retrospective study

Journal of Allergy and Clinical Immunology: Global
Background: Retrospective data are limited on the effectiveness of mepolizumab treatment that is reflective of real-world practice in patients with chronic rhinosinusitis with nasal polyps (CRSwNP).
Juan Carlos Cardet, MD, MPH, Jared Silver, MD, Martin Maldonado-Puebla, MD, François Laliberté, MA, Chi Gao, PhD, Ramya Ramasubramanian, PhD, Annalise Hilts, BA, Kaixin Zhang, MSc, Jeremiah Hwee, PhD, Waseem Ahmed, MBA, Amy G. Edgecomb, PharmD, MPH   +10 more
doaj   +1 more source

A real-world study to evaluate effectiveness of mepolizumab in treating severe asthma in Taiwan (REMIT)

Therapeutic Advances in Respiratory Disease
Background: REMIT is the first real-world study of mepolizumab effectiveness in patients with severe asthma (SA) in Taiwan. Objectives: The primary objective evaluated changes in clinically significant exacerbations (CSEs; defined as use of oral ...
Shih-Lung Cheng, Shu-Min Lin, Chung-Kan Peng, Ming-Cheng Chan, Sheng-Yeh Shen, Ping-Hung Kuo, Chien-Hao Lai, Chou-Chin Lan, Chung-Yu Chen, Ching-Hsiung Lin, Kuang-Ming Liao, Po-Hao Feng, Jiin-Torng Wu, Yu-Feng Wei, Xiaomeng Xu, Rafael Alfonso-Cristancho, Tina Lai, Aldo Navarro, Dominique Milea, Diahn-Warng Perng   +19 more
doaj   +1 more source