Results 61 to 70 of about 10,401 (200)

A Case of Eosinophilic Gastroenteritis Remission Achieved Steroid-Free With Mepolizumab

Gastro Hep Advances, 2022
Eosinophilic gastroenteritis is an eosinophilic inflammatory disease that responds well to steroids but often relapses upon their discontinuation, necessitating maintenance treatment.
Yuki Hirata, Takahiko Nakamura, Kazuhide Higuchi   +2 more
doaj   +1 more source

Update on Biological Therapeutics for Asthma [PDF]

, 2010
: Asthma poses a significant burden on patients, families, health care providers, and the medical system. While efforts to standardize care through guidelines have expanded, difficulty in managing severe asthma has encouraged research about its ...
Bruce S. Bochner, Marisha L. Cook
core   +1 more source

Straight to Phase III: Model‐Informed Approach Speeds Depemokimab Clinical Development in Interleukin‐5‐Driven Diseases

Clinical Pharmacology &Therapeutics, EarlyView.
Straight to Phase III: Model‐informed approach speeds depemokimab clinical development in interleukin‐5‐driven diseases. IL‐5, a key mediator of type 2 inflammation, underlies various diseases, including severe asthma, CRSwNP, EGPA, and HES. Reduction in blood eosinophil count (BEC), a biomarker of IL‐5 activity, is commonly used to evaluate the ...
Chiara Zecchin, Stein Schalkwijk, Isabelle J. Pouliquen, Alienor Berges, Nicholas Bird, Richard Follows, Daren Austin   +6 more
wiley   +1 more source

Beyond eosinophils: A proteomic dissection of remodeling and inflammation in suspected eosinophilic esophagitis

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Eosinophilic esophagitis (EoE) is characterized by eosinophilic inflammation and epithelial remodeling. However, current biomarkers focus predominantly on eosinophilia, overlooking basal cell hyperplasia (BCH), a histologic feature that may persist despite treatment.
Adi Eindor‐Abarbanel, Nimrod Moss‐ Ophir, Netanel Agajany, Daniel L. Cohen, Vered Richter, Haim Shirin, Efrat Broide, Tzippora Shalem   +7 more
wiley   +1 more source

Mepolizumab reduces exacerbations in patients with severe eosinophilic asthma, irrespective of body weight/body mass index: meta-analysis of MENSA and MUSCA

Respiratory Research, 2019
Background We assessed the efficacy of the licensed mepolizumab dose (100 mg subcutaneously [SC]) in patients with severe eosinophilic asthma according to body weight/body mass index (BMI).
Frank C. Albers, Alberto Papi, Camille Taillé, Daniel J. Bratton, Eric S. Bradford, Steven W. Yancey, Namhee Kwon   +6 more
doaj   +1 more source

Impact of Early Versus Delayed Functional Endoscopic Sinus Surgery for Chronic Rhinosinusitis With Nasal Polyps

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Previous studies have suggested a benefit to early functional endoscopic sinus surgery (FESS) for chronic rhinosinusitis (CRS). With the approval of T2 biologics for CRS with nasal polyps (CRSwNP), it is important to re‐evaluate FESS timing in relation to T2 biologic utilization.
Radhika Duggal, Trisha Shang, David R. Hoying, David Kaelber, Mohamad R. Chaaban   +4 more
wiley   +1 more source

Genetic basis for personalized medicine in asthma [PDF]

, 2012
There is heterogeneity in patient responses to current asthma medications. Significant progress has been made identifying genetic polymorphisms that influence the efficacy and potential for adverse effects to asthma drugs, including; β2-adrenergic ...
Asano, Barnes, Basu, Bleecker, Bleecker, Choudhry, Corren, Currie, Drazen, Drysdale, Duan, Duroudier, Ferreira, Finotto, Gaston, Gudbjartsson, Haldar, Hall, Hammad, Hawkins, Hawkins, Hayakawa, Himes, Holloway, Ian Sayers, Israel, Jin, Kang, Kearley, Kim, Klotsman, Koster, Lee, Lee, Lima, Lima, Litonjua, Liu, Maarsingh, Malmstrom, Mastalerz, Meurs, Michael Portelli, Moffatt, Moffatt, Moore, Mougey, Obeidat, Ober, Oshikawa, Panebra, Panebra, Pascual, Prefontaine, Reihsaus, Risma, Sampson, Savenije, Sayers, Sayers, Slager, Sleiman, Stevens, Tantisira, Tantisira, Tantisira, Tantisira, Torgerson, Trian, Tse, Vonk, Wechsler, Wenzel, Whalen, Whelan, Ye, York   +76 more
core   +2 more sources

Association of autoimmune diseases with biologic agents targeting type 2 immunity: An observational study using a claims database

Rheumatology &Autoimmunity, EarlyView.
This observational study assessed the association between anti‐type 2 biologic agents and the occurrence of autoimmune diseases using a large real‐world claims database. Anti‐IL‐5 and anti‐IgE therapies were associated with an increased occurrence of autoimmune diseases, including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE ...
Shoichiro Inokuchi
wiley   +1 more source

Personalized medicine with biologics for severe type 2 asthma : current status and future prospects [PDF]

, 2017
Asthma affects more than 300 million people worldwide and poses a large socioeconomic burden, particularly in the 5% to 10% of severe asthmatics. So far, each entry of new biologics in clinical trials has led to high expectations for treating all severe ...
Blanchetot, Christophe, Brusselle, Guy, de Haard, Hans, Godar, Marie, Lambrecht, Bart   +4 more
core   +3 more sources

Integrative Analysis of Plasma Proteome and Genome Reveals Novel Drug Targets for Chronic Rhinosinusitis and Nasal Polyps

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) and nasal polyps (NP) are chronic inflammatory conditions with unsatisfactory treatment outcomes due to frequent recurrence of refractory disease. Identifying new therapeutic targets is essential. Methods We conducted a proteome‐wide Mendelian randomization (MR) analysis by integrating genome‐wide ...
En Zhou, Shi Luo, Yu Xiao, Bin Liu, Xu‐Ping Xiao   +4 more
wiley   +1 more source