Results 91 to 100 of about 232 (109)
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Casein Nanoparticles as Oral Delivery Carriers of Mequindox for the Improved Bioavailability
Colloids and Surfaces B: Biointerfaces, 2020Mequindox (Meq) is a promising broad-spectrum antibacterial agent, but the clinical application of Meq has been hampered by its low oral bioavailability. Casein (Cas) can bind to a variety of poorly water-soluble drugs to improve their water solubility through a micellar solubilization mechanism. Here, a low-cost and convenient method was introduced to
Xiaoxia Liang, Ling Zhao, Ju-Chun Lin
exaly +3 more sources
Genotoxicity Evaluation of Mequindox in Different Short-Term Tests
Food and Chemical Toxicology, 2013Quinoxaline-1,4-dioxides (QdNOs) are the potent heterocyclic N-oxides with interesting biological properties such as antibacterial, anticandida, antitubercular, anticancer and antiprotozoal activities. Here, we tested and compared the mequindox (MEQ) for mutagenic abilities in a battery of different short term tests according to OECD guidelines.
Awais Ihsan +2 more
exaly +3 more sources
Pharmacokinetics of Mequindox and Its Metabolites in Swine
Agricultural Sciences in China, 2011Abstract The present study was carried out to investigate the pharmacokinetics of mequindox (MEQ), a new synthetic quinoxaline 1,4-dioxide derivative and its two main metabolites M1 [2-isoethanol mequinoox], M2 [2-isoethanol 1-desoxymequindox] in healthy swine.
Qi Shan, Fan Yang
exaly +2 more sources
The Metabolism of Carbadox, Olaquindox, Mequindox, Quinocetone and Cyadox: An Overview
Medicinal Chemistry, 2013The aim of this article is to get an overview of the metabolism of quinoxaline 1,4-di-N-oxides (QdNOs) used in food animals. The derivatives of QdNOs (carbadox, olaquindox, mequindox, quinocetone, and cyadox) are the potent synthetic antimicrobial agents that are used for improving the feed efficiency and controlling dysentery in food-producing animals.
Zhao-Ying, Liu, Zhi-Liang, Sun
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Solubility and Dissolution Thermodynamic Properties of Mequindox in Binary Solvent Mixtures
Journal of Molecular Liquids, 2020Abstract The solubility of Mequindox(MEQ) in two kinds of binary mixtures(acetone+isopropanol; N-propanol+N-butanol) with different ratio was determined by shake flask method through UV–Vis spectrophotometer over the temperature from 293.15 to 323.15 K at atmospheric pressure(p = .1 MPa).
Hualin Fu, Haibo Dou, Zhixiang Yuan
exaly +2 more sources
Mequindox Resistance and in Vitro Efficacy in Animal-Derived Escherichia coli Strains
Veterinary Microbiology, 2015This study investigated the in vitro efficacy of mequindox against enteropathogenic Escherichia coli (EPEC), and characterized the oqxAB genes as the main mequindox resistance determinant in E. coli strains of animal origin. A total of 1123 E.
Yang Wang, Congming Wu
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Pharmacokinetics of Mequindox and Its Metabolites in Rats After Intravenous and Oral Administration
Research in Veterinary Science, 2012Pharmacokinetics of mequindox (MEQ) and its metabolites were determined in rats after intravenous (i.v.) and oral (p.o.) administration of MEQ at a single dose of 10 mg kg(-1) bodyweight. After both administrations, MEQ and five of its metabolites were quantified, except M4, whereas M1 and M2 were the predominant ones. The areas under the concentration-
Qi Shan, Fan Yang, Huanzhong Ding
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Cytotoxicity of Mequindox and Its Metabolites in HepG2 Cells in Vitro and Murine Hepatocytes in Vivo
Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 2016Mequindox, a quinoxaline 1,4-dioxide, is widely used as a feed additive in the Chinese livestock industry because of its effective antibacterial properties. Many recent studies have found that mequindox is rapidly metabolized to numerous metabolites following administration to animals.
Xue Feiqun, Quan Wang, Yingchun Liu
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Mequindox Induces Apoptosis, DNA Damage, and Carcinogenicity in Wistar Rats
Food and Chemical Toxicology, 2019Mequindox (MEQ) is a synthetic antibacterial agent. Recent studies showed that MEQ and its primary metabolites exhibit strong genotoxicity to mammalian cells, and MEQ induced carcinogenicity in mice. These findings suggest that chronic exposure to MEQ could lead to an increased risk of cancer later in life.
Changqin Gu, Zonghui Yuan, Xu Wang
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Dynamic changes in metabolic profiles of rats subchronically exposed to mequindox
Molecular BioSystems, 2014Abstract Mequindox is widely used as an antibacterial veterinary drug and a feeding additive for farm animals in China. Although its toxicity has been widely studied, little is known regarding the metabolic effects of subchronic exposure to mequindox, which is vital for the health of meat producing livestock.
Limiao, Jiang +5 more
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