Results 101 to 109 of about 232 (109)
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Journal of Separation Science, 2012
A rapid liquid chromatography tandem mass spectrometric method was developed for the simultaneous determination of mequindox and its five metabolites (2‐isoethanol mequindox, 2‐isoethanol 1‐desoxymequindox, 1‐desoxymequindox, 1,4‐bisdesoxymequindox, and 2‐isoethanol bisdesoxymequindox) in porcine muscle, liver, and kidney, fulfilling confirmation ...
Binghu Fang +2 more
exaly +3 more sources
A rapid liquid chromatography tandem mass spectrometric method was developed for the simultaneous determination of mequindox and its five metabolites (2‐isoethanol mequindox, 2‐isoethanol 1‐desoxymequindox, 1‐desoxymequindox, 1,4‐bisdesoxymequindox, and 2‐isoethanol bisdesoxymequindox) in porcine muscle, liver, and kidney, fulfilling confirmation ...
Binghu Fang +2 more
exaly +3 more sources
Analytical Letters, 2012
Drug metabolism studies in vitro were carried out inexpensively and readily to serve as an adequate mechanism to characterize drug metabolites, elucidate their pathways, and make suggestions for further testing in vivo. In this work, the comparative metabolism of mequindox (MEQ) was investigated in vitro by incubation with chicken liver microsomes ...
Shupeng Yang +2 more
exaly +2 more sources
Drug metabolism studies in vitro were carried out inexpensively and readily to serve as an adequate mechanism to characterize drug metabolites, elucidate their pathways, and make suggestions for further testing in vivo. In this work, the comparative metabolism of mequindox (MEQ) was investigated in vitro by incubation with chicken liver microsomes ...
Shupeng Yang +2 more
exaly +2 more sources
Food Chemistry, 2014
This report presents a UPLC-MS/MS method for determination of mequindox (MEQ), quinocetone (QCT) and their 11 metabolites in chicken and pork samples. Following extraction process with acetonitrile-ethyl acetate, acidulation, and re-extraction with ethyl acetate in turn, target analytes were further purified using C18 solid phase extraction (SPE ...
Shupeng Yang, Ross C Beier, Yanshen Li
exaly +3 more sources
This report presents a UPLC-MS/MS method for determination of mequindox (MEQ), quinocetone (QCT) and their 11 metabolites in chicken and pork samples. Following extraction process with acetonitrile-ethyl acetate, acidulation, and re-extraction with ethyl acetate in turn, target analytes were further purified using C18 solid phase extraction (SPE ...
Shupeng Yang, Ross C Beier, Yanshen Li
exaly +3 more sources
Toxicology Letters, 2009
Mequindox (MEQ) is a synthetic quinoxaline 1,4-dioxides (QdNOs) derivative which can effectively improve growth and feed efficiency in animals. This study was to investigate the dose-dependent long-term toxicity in the adrenal of male rats exposed to 180 days of MEQ feed.
Xian-Ju Huang +2 more
exaly +3 more sources
Mequindox (MEQ) is a synthetic quinoxaline 1,4-dioxides (QdNOs) derivative which can effectively improve growth and feed efficiency in animals. This study was to investigate the dose-dependent long-term toxicity in the adrenal of male rats exposed to 180 days of MEQ feed.
Xian-Ju Huang +2 more
exaly +3 more sources
Carbonyl Reduction of Mequindox by Chicken and Porcine Cytosol and Cloned Carbonyl Reductase 1
Drug Metabolism and Disposition, 2012Mequindox (MEQ) is a novel synthetic quinoxaline 1,4-dioxides derivative, which is widely used as a veterinary drug and animal feed additive. However, the metabolic mechanism of MEQ is rarely reported. The N-oxide reduction mechanism of MEQ was reported in our previous work.
Xianqing, Tang +6 more
openaire +2 more sources
Analysis of mequindox and its two metabolites in swine liver by UPLC-MS/MS
Analytical Methods, 2012A new ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method was developed for the determination of mequindox (MEQ) and its two metabolites (1-desoxymequindox and 1, 4-bisdesoxymequindox, 1-DMEQ and BDMEQ) in swine liver. This method was validated on the basis of Commission Decision 2002/657/EC.
Kaili Liu +6 more
openaire +1 more source
Journal of Chromatography B, 2012
Mequindox (MEQ), 3-methyl-2-quinoxalinacetyl-1,4-dioxide, is widely used in Chinese veterinary medicine as an antimicrobial and feed additive. Its toxicities have been reported to be closely related to its metabolism. To understand more clearly the metabolic pathways of MEQ, its metabolism in chickens was studied using liquid chromatography coupled ...
Qi, Shan +7 more
openaire +2 more sources
Mequindox (MEQ), 3-methyl-2-quinoxalinacetyl-1,4-dioxide, is widely used in Chinese veterinary medicine as an antimicrobial and feed additive. Its toxicities have been reported to be closely related to its metabolism. To understand more clearly the metabolic pathways of MEQ, its metabolism in chickens was studied using liquid chromatography coupled ...
Qi, Shan +7 more
openaire +2 more sources