Results 81 to 90 of about 232 (109)
Study of transport, tissue distribution, depletion, and hepatotoxicity of Cyadox, a quinoxaline-1,4-dioxide derivative. [PDF]
Front PharmacolTao Z +5 more
europepmc +1 more source
Resistance in gram-negative bacilli: the emergence of RND efflux pumps. [PDF]
Future MicrobiolAgreles MAA +5 more
europepmc +1 more source
Systems Responses of Rats to Mequindox Revealed by Metabolic and Transcriptomic Profiling
Journal of Proteome Research, 2012 Mequindox is used as an antibiotic drug in livestock; however, its toxicity remains largely unclear. Previously, we investigated metabolic responses of mice to mequindox exposure. In order to evaluate dependences of animal species in response to mequindox insult, we present the metabolic consequences of mequindox exposure in a rat model, by employing ...
Fuhua Hao, Yulan Wang, Huiru Tang
exaly +4 more sources
Catalytic Characteristics of CYP3A22-Dependent Mequindox Detoxification
Catalysis Communications, 2011 Abstract The anti-bacterial agent mequindox is widely used as an animal feed additive in China. Its potential effect on host cells, however, remains largely unknown. Here, we report that pig CYP3A22 represents an important metabolic enzyme in mequindox catalysis.
Yiqun Deng, Michael Huen
exaly +5 more sources
Mequindox Induced Cellular DNA Damage via Generation of Reactive Oxygen Species
Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 2012 Mequindox, a quinoxaline-N-dioxide derivative that possesses antibacterial properties, has been widely used as a feed additive in the stockbreeding industry in China. While recent pharmacological studies have uncovered potential hazardous effects of mequindox, exactly how mequindox induces pathological changes and the cellular responses associated with
Yiqun Deng, Michael Huen
exaly +6 more sources
Dynamic Metabolic Response of Mice to Acute Mequindox Exposure
Journal of Proteome Research, 2011 Mequindox is used as a veterinary antibiotic drug. As part of systematic investigations into mequindox as a veterinary medicine and its subsequent applications in food safety, we conducted the investigation to assess the metabolic response of mice to mequindox using metabonomics, which combines NMR metabolic profiles of biofluids or tissues and pattern
Yulan Wang, Huiru Tang, Xiu-Ju Zhao
exaly +4 more sources
Acute and Subchronic Toxicological Evaluation of Mequindox in Wistar Rats
Regulatory Toxicology and Pharmacology, 2010 We studied an acute and subchronic oral toxicity of Mequindox (MEQ), a quinoxaline 1,4-dioxide antimicrobial promoter, in Wistar rats according to OECD guidelines. For acute toxicity study, single doses of MEQ at 175, 550 and 2000 mg/kg b.w. were administered to rats by oral gavage. The calculated LD(50) was 550 mg/kg b.w.
Xian-Ju Huang +2 more
exaly +4 more sources
Research in Veterinary Science, 2012 Pharmacokinetics of mequindox and one of its major metabolites (M) was determined in chickens after intravenous (i.v.), intramuscular (i.m.) and oral administration of mequindox at a single dose of 10 (i.v. and i.m.) or 20 mg/kg b.w. (oral). Plasma concentration profiles were analyzed by a non-compartmental pharmacokinetic method.
Fan Yang, Huanzhong Ding, Zhenling Zeng
exaly +4 more sources
Journal of Agricultural and Food Chemistry, 2016 This research described a sensitive and rapid UPLC-MS/MS method for the determination of mequindox and its six major metabolites in chicken muscle, chicken liver, swine muscle, and swine liver. Among the metabolites, carbonyl reduction-1,4-bisdesoxy-mequindox is novel.
Yanshen Li, Yanli You
exaly +4 more sources