Selective Action of Mercaptoethylamines on Melanocytes in Mammalian Skin
Experiments with various topically applied compounds have demonstrated that 2-mercaptoethylamine HCI (MEA) and N(2-mercaptoethyl)-dimethylamine HCI (MEDA) are very potent agents that cause depigmentation in treated areas only. When applied to the skin of black guinea pigs, they inhibited melanogenesis, acted selectively on melanocytes, decreased ...
Edgar Frenk
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Skin Depigmenting Agents: Where Do We Stand? [PDF]
Skin hyperpigmentary disorders are frequent and psychologically disturbing conditions for patients. Skin depigmenting agents have been widely used for the treatment of such disorders. The most efficacious depigmenting agents, such as hydroquinone and the
Kasraee, Behrooz
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Protection Against Radiation Lethality: Effect of -Mercaptoethylamine.
Summary and ConclusionsSome 32% of the Swiss albino and 67% of the CF1 male mice injected intraperitoneally with β-mercaptoethylamine (i.e., cysteinamine) prior to a lethal exposure of 700 r whole body x-irradiation survived the 30-day observation period. Some 97% of these are still alive 60 days after irradiation.
R, RUGH, S C, WANG
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Studies on Oxygen Poisoning: Protective Effect of -Mercaptoethylamine
ConclusionsMice exposed to 6 atmospheres of oxygen are protected and their survival prolonged 70% by previous intraperitoneal injection of 3.33 mg of β-mercaptoethylamine per 20 g body weight.
R, GERSCHMAN +4 more
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Osteolathyrogenic Action of Mercaptoethylamine and of Cystamine.
SummaryThe osteolathyrogenic action of β-mercaptoethylamine (cysteamine), when fed to rats as the hydrochloride, was confirmed. Cystamine was found to have similar properties. Gross and microscopic skeletal changes were similar to those produced by osteolathyrogenic nitriles.
W, DASLER, R V, MILLISER
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Some Central Nervous System Actions of Beta-Mercaptoethylamine
Summary1. MEA synergizes with pentyl-enetetrazole to produce death in mice when it is injected simultaneously with it, or at 15, 30, 60, or 120 minutes preceding it. Thus, MEA has a stimulant action which comes on rapidly after intraperitoneal injection and endures for at least 2 hours. 2.
A J, East +5 more
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The Coordination Chemistry of Some Sulphur-Nitrogen Ligands
Some nickel(II) and copper(II) complexes of 2-(benzylthio)ethylamine have been isolated and characterised with respect to infrared and electronic spectra. With nickel(II) only the bis salts were obtained and they were all paramagnetic.
Galyer, Allen Lee
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Computing Network of Diseases and Pharmacological Entities through the Integration of Distributed Literature Mining and Ontology Mapping [PDF]
The proliferation of -omics (such as, Genomics, Proteomics) and -ology (such as, System Biology, Cell Biology, Pharmacology) have spawned new frontiers of research in drug discovery and personalized medicine.
Faisal, Fazle Elahi
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Investigations of the Active Site of Microsomal Leucine Aminopeptidase by Probing with Ethylenediamine Derivatives [PDF]
The active site of porcine microsomal aminopeptidase was probed by studying the inhibition of the enzyme using derivatives of ethylenediamine and diaminopropionic acid.
Chan, Lincoln
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POLY(ESTERTHIOETHERAMINES), A NEW FAMILY OF TERTIARY AMINO POLYMERS
The aim of this letter is to report some preliminary results on the synthesis of a new family of tertiary amino polymers, poly(esterthioetheramines), as part of a wider research work on synthetic polymers containing the aminic function in the main chain.
E. Ranucci, P. Ferruti
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