Results 171 to 178 of about 4,546 (178)

MeRIP-seq

2022
MeRIP-seq of B16 ...
openaire   +1 more source

Detecting differentially methylated mRNA from MeRIP-Seq with likelihood ratio test

2014 IEEE Global Conference on Signal and Information Processing (GlobalSIP), 2014
The study of mRNA methylation is an emerging research field greatly fueled by recent advancement in high throughput sequencing technology. We propose here a binomial likelihood ratio test ("bltest") aiming at detecting differentially methylated mRNA with MeRIP-Seq data, "bltest" models the read counts of each RNA methylation site in IP and input ...
Lin Zhang, Jia Meng, Hui Liu, Xiaodong Cui, Shao-Wu Zhang, null Yidong Chen, null Yufei Huang   +6 more
openaire   +1 more source

Modeling of replicates variances for detecting RNA methylation site in MERIP-SEQ data

2015 IEEE China Summit and International Conference on Signal and Information Processing (ChinaSIP), 2015
The recent advent of the state-of-art high throughput sequencing technology, known as Methylated RNA immunoprecipitation (IP) sequencing (MeRIP-Seq), provided the biologists the first global view of epigenetic modifications on the transcriptome at a high resolution.
Xiaodong Cui, Jia Meng, Shaowu Zhang, Yufei Huang   +3 more
openaire   +1 more source

MeRIP-seq/scRNA-seq Code

These are the codes for MeRIP-seq/scRNA-seq analysis used in the paper titled "METTL3-Driven RNA Modifications: A Key Mechanism and Potential Therapeutic Target in Pancreatic Acinar Cell Carcinoma in Mice". The relevant GEO accession numbers are as follows: GSE305529, GSE305530.
Tatekawa, Shotaro, Hara, Tomoaki, Meng, Sikun, Sato, Tetsuya, Ishii, Hideshi   +4 more
openaire   +1 more source

MeRIP-Seq for Identifying Stress-Responsive Transcriptome-Wide m6A Profiles in Plants

Recent advancements in detection and mapping methods have enabled researchers to uncover the biological importance of RNA chemical modifications, which play a vital role in post-transcriptional gene regulation. Although numerous types of RNA modifications have been identified in higher eukaryotes, only a few have been extensively studied for their ...
Ganesan, Govindan, Ramanjulu, Sunkar
openaire   +2 more sources

m6A modification profiles of the CHO cells with differential recombinant protein expression using MeRIP-seq/RNA-seq

International Journal of Biological Macromolecules
Chinese hamster ovary (CHO) cells remain the primary host system for recombinant therapeutic protein production. Enhancing transgene expression efficiency while maintaining stable production persists as a key challenge in CHO cell engineering. While N6-methyladenosine (m6A) modification - the most abundant RNA methylation - regulates RNA stability and ...
Wen, Wang, Hai-Tong, Wang, Yang, Guo, Qi, Zhao, Jiang-Tao, Lu, Zhao-Ming, Cui, Xi, Zhang, Le-Le, Qiu, Xiao-Yin, Wang, Tian-Yun, Wang, Yan-Long, Jia   +10 more
openaire   +2 more sources

MeRIP-seq data analysis and validation reveal the regulatory role of m6A modified circRNAs in the apoptosis of secondary hair follicle cells in Inner Mongolia cashmere goats

Comparative Biochemistry and Physiology Part D: Genomics and Proteomics
As a widely epigenetic modification, m6A (N6-methyladenosine, m6A) can regulate the degradation, translation, and other biological functions of circRNAs through dynamic reversible processes. It plays an important role in regulating the life activities of biological organisms, particularly in cell differentiation, apoptosis, embryonic development ...
Ru, Zhang, Jiayue, Liang, Zhaomin, Liu, Jiale, Chang, Junjie, Zhang, Zhanxiong, Zhang, Rui, Li, Wei, Zhao, Yongyuan, Deng, Hongmei, Xiao   +9 more
openaire   +2 more sources

Exploring the transcriptomic and m6a landscape of human chromosome 17 in breast cancer: A combined RNA-seq and MeRIP-Seq analysis

Theoretical and Natural Science
Abstract. N6-methyladenosine (m6A), recognized as the most prevalent post-transcriptional modification in organisms, has been substantiated to exert a significant influence on the genetic mechanisms underlying breast cancer. To delve deeper into the disparities in expression, modification, and interactions between mRNA and m6A in breast cancer (BC), we
openaire   +1 more source