Results 91 to 100 of about 4,040 (201)

α‐Triazolylboronic Acids: A Novel Scaffold to Target FLT3 in AML

ChemMedChem, Volume 20, Issue 1, January 2, 2025.
Boronic acids represent an intriguing and unexplored class of compounds in the context of acute myeloid leukemia (AML), and they are only scantly reported as inhibitors of protein kinases. The screening of an in‐house library of boronic compounds identified α‐triazolylboronic acids as a novel chemotype for targeting FLT3 in AML. Selected compounds show
Maria Luisa Introvigne, Lorenza Destro, Luca Mologni, Valentina Crippa, Paolo Zardi, Francesco Fini, Fabio Prati, Emilia Caselli, Alfonso Zambon   +8 more
wiley   +1 more source

Cefiderocol‐Resistant Elizabethkingia anophelis Bacteremia Following WATCHMAN Implantation: A Case Report and Review of the Literature

Case Reports in Infectious Diseases, Volume 2025, Issue 1, 2025.
Elizabethkingia anophelis is an emerging pathogen associated with nosocomial and community outbreaks. Treatment of infection caused by E. anophelis is not well‐defined given its extensive drug resistance profile, and infection carries a poor prognosis. E.
Anna DeFrank, Michael Bosco, Sigridh Muñoz Gómez, Amit Dhaliwal, Priya Gusain   +4 more
wiley   +1 more source

Meropenem-Vaborbactam versus Ceftazidime-Avibactam for Treatment of Carbapenem-Resistant Enterobacteriaceae Infections

Antimicrobial Agents and Chemotherapy, 2020
The comparative efficacy of ceftazidime-avibactam and meropenem-vaborbactam for treatment of carbapenem-resistant Enterobacteriaceae (CRE) infections remains unknown. This was a multicenter, retrospective cohort study of adults with CRE infections who received ceftazidime-avibactam or meropenem-vaborbactam for ≥72 ...
Renee, Ackley, Danya, Roshdy, Jacqueline, Meredith, Sarah, Minor, William E, Anderson, Gerald A, Capraro, Christopher, Polk   +6 more
openaire   +3 more sources

A Case of Nocardia kroppenstedtii Infection Successfully Treated With a Multidisciplinary Approach

Case Reports in Infectious Diseases, Volume 2025, Issue 1, 2025.
Nocardia species constitute a diverse group of microorganisms classified as aerobic actinomyces. Among these species, many have been implicated as causative agents of severe human infections, particularly in immunocompromised patients, affecting lungs, skin, and nervous system.
Francesco Foglia, Annalisa Ambrosino, Giuseppe Greco, Annalisa Chianese, Carla Zannella, Francesca Cinone, Alfonso Reginelli, Diego Sandro Giordano, Giovanni Tortorella, Maria Teresa Laieta, Anna De Filippis, Massimiliano Galdiero, Rita Greco, Emiliana Finamore, Rajib Chowdhury   +14 more
wiley   +1 more source

Carbapenem‐Resistant Klebsiella pneumoniae Isolated From a Patient in a Midwestern U.S. Hospital With a History of Indian Travel: Therapeutic Strategies and Clinical Outcomes

Case Reports in Infectious Diseases, Volume 2025, Issue 1, 2025.
Carbapenemases have had increasing prevalence within the United States and worldwide. Here, we present a case of carbapenem‐resistant Klebsiella pneumoniae (CRKP) which is unique due to the rarity of multiple mechanisms of resistance within the Klebsiella pneumoniae harboring New Delhi metallo‐β‐lactamases (NDM), oxacillinase‐48 (OXA‐48)‐like, and ...
Christopher Phan, Kristen Tsai, Christian M. Gill, Robin Chamberland, Christian Hendrix, Rong Hou, Dawei Cui   +6 more
wiley   +1 more source

Antimicrobial susceptibility of enterobacterales causing bloodstream infection in United States medical centres: comparison of aztreonam-avibactam with beta-lactams active against carbapenem-resistant enterobacterales

BMC Infectious Diseases
Background Bloodstream infection (BSI) is associated with poor outcomes especially when effective antimicrobial therapy and control of infection source are delayed.
Helio S. Sader, John H. Kimbrough, Rodrigo E. Mendes, Mariana Castanheira   +3 more
doaj   +1 more source

In Vitro Activity of “Old” and “New” Antimicrobials against the Klebsiella pneumoniae Complex

Antibiotics
The Klebsiella pneumoniae complex is a commonly isolated bacteria in human infections. These opportunistic pathogens pose a serious threat to public health due to their potential transmission to the human population.
Alicja Sękowska
doaj   +1 more source

Spotlight commentary: Treatment of multidrug‐resistant Gram‐negative infections in the era of growing antimicrobial resistance

British Journal of Clinical Pharmacology, Volume 91, Issue 9, Page 2485-2489, September 2025.
Luka Bielen, Andro Vujević, Luka Csenar
wiley   +1 more source

Cockroaches as Reservoirs, Vectors, and Potential Sentinels of Multidrug‐Resistant Bacteria in Ugandan Communities: A Retrospective Analysis

Global Health, Epidemiology and Genomics, Volume 2025, Issue 1, 2025.
Background: Cockroaches could play a role in the transmission dynamics of antimicrobial‐resistant bacteria (ARB) at variable interfaces in Ugandan communities, acting as both reservoirs and vectors. This study investigated the burden and diversity of ARB carried by cockroaches in human settlements in Uganda, so as to understand their role in the spread
Steven Kakooza, Paul Ssajjakambwe, Rebecca Nalubega, Betty Namazi, Aisha Nantume, Geoffrey Ssentamu, Esther Nabatta, David Nalumenya, Mariam Wanyana, Damien F. N. Munyiirwa, Dorcus Namuyinda, Sayaka Tsuchida, Kazunari Ushida, John Baligwamunsi Kaneene, Omar Enzo Santangelo   +14 more
wiley   +1 more source

Revisiting the Metallo‐β‐Lactamase–Mediated Antibiotic Resistance: Exploring Novel Mechanisms and Therapeutic Strategies

International Journal of Microbiology, Volume 2025, Issue 1, 2025.
β‐Lactam resistance is one of the major health concerns today, primarily due to enzymes called β‐lactamases. Metallo‐β‐lactamases (MβLs) can cleave a wide range of β‐lactam antibiotics, including carbapenems. These enzymes require zinc (Zn) ions to function and can be inhibited by conventional β‐lactamase inhibitors.
Jahanvi Saini, Silvi Gautam, Divakar Sharma, Ankit Khanduri, Divya Venugopal, Guilherme Dilarri   +5 more
wiley   +1 more source