Results 121 to 130 of about 78,101 (219)
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang +19 more
wiley +1 more source
Background/Objectives: The thermal stability and degradation kinetics of β-lactam antibiotics are critical for understanding their behavior under processing and storage conditions.
Ovidiu Ghirlea +9 more
doaj +1 more source
The methanolic extract of Cinnamomum verum exhibited antibacterial and antibiofilm activities, enhanced the efficacy of conventional antibiotics against multidrug‐resistant bacteria, and showed favorable interactions with key bacterial targets in molecular docking analyses, supporting its potential as a natural antimicrobial adjuvant for combating ...
Hayet Edziri +11 more
wiley +1 more source
ABSTRACT A 67‐year‐old man with decades of untreated sickle cell disease developed septic shock with multiorgan failure, splenic infarction, and marrow fibrosis; his genotype could not be confirmed. He recovered with intensive supportive care, with hydroxyurea initiated for long‐term disease modification, illustrating catastrophic infection‐triggered ...
Sara Shahidi, Gisha Mohan
wiley +1 more source
Yusuf YAKUPOĞULLARI +4 more
doaj +1 more source
Vasopressor‐Associated Limb Ischemia Resulting in Quadruple Amputation in Suspected Septic Shock
ABSTRACT Vasopressor‐associated limb ischemia (VALI) is a rare but devastating complication of vasopressor therapy in septic shock. This case shows catastrophic four‐limb amputation in a 26‐year‐old obese male with suspected septic shock. This case illustrates the complex interplay between prolonged high‐dose vasopressor therapy, morbid obesity, and ...
Muni Rubens +8 more
wiley +1 more source
ABSTRACT Robot‐assisted transanal minimally invasive surgery (TAMIS) is a safe and effective platform for the local excision of early rectal lesions. While postoperative complications such as bleeding or contained perforation are recognized, rapidly progressive retroperitoneal sepsis remains an exceedingly rare occurrence.
Jonathan Tiong +4 more
wiley +1 more source
ABSTRACT A 42‐year‐old male amateur football player presented with a 17‐day history of progressive groin pain, primarily on the right, radiating to the perineum, associated with limitation of hip motion. Because of proximal weakness and elevated inflammatory markers, polymyositis and an infectious process were initially suspected.
Sousan Kolahi +4 more
wiley +1 more source
In a multicenter, randomized, open comparison of meropenem to ceftazidime as empiric treatment of severe acute infections, 185 children (1 mo-15 years old, mean 65.4 mo) were enrolled. Meropenem (20 mg/kg t.i.d.
P. Marchisio, N. Principi
core +2 more sources
Abstract Accurate drug concentration measurement is essential for precision pharmacotherapy, but conventional therapeutic drug monitoring (TDM) requires venous sampling, increasing patient burden, and potentially limiting participation in TDM and model‐informed precision dosing (MIPD).
Hari Prabhath Tummala +5 more
wiley +1 more source

