Results 91 to 100 of about 33,075 (171)

Duration of naturally acquired antibody responses to blood-stage Plasmodium falciparum is age dependent and antigen specific.

, 2008
Naturally acquired antibody responses provide partial protection from clinical malaria, and blood-stage parasite vaccines under development aim to prime such responses. To investigate the determinants of antibody response longevity, immunoglobulin G (IgG)
Conway, David J, Samuel Dunyo, Tetteh, Kevin KA, Dunyo, Samuel, Lanar, David E, Akpogheneta, Onome J, Margaret Pinder, Duah, Nancy O, Pinder, Margaret, David E. Lanar, David J. Conway, Onome J. Akpogheneta, Nancy O. Duah, Kevin K. A. Tetteh   +13 more
core   +1 more source

A simple, ex vivo phagocytosis assay of Plasmodium vivax merozoites by flow cytometry

Memorias do Instituto Oswaldo Cruz
As phagocytosis is the first line of defense against malaria, we developed a phagocytosis assay with Plasmodium vivax (P. vivax) merozoites that can be applied to evaluate vaccine candidates. Briefly, after leukocyte removal with loosely packed cellulose
Elizangela Farias, Fhabiane Bezerra, Djane Clarys Baia-da-Silva, Yury Oliveira Chaves, Tatiana Bacry Cardoza, Maria Edilene Martins de Almeida, Lucas Barbosa Oliveira, Pritesh Lalwani, Patrícia Puccinelli Orlandi, Marcus Vinicius Guimaraes Lacerda, Stefanie Costa Pinto Lopes, Paulo Afonso Nogueira   +11 more
doaj   +1 more source

Merozoite-specific IgG according to clinical category.

, 2018
Levels (AU) of IgG specific for PfRH5 (A), CyRPA (B), Pf113 (C), EBA175 (D), GLURP-R0 (E) and GLURP-R2 (F) in plasma of individual children according to clinical category: SM (severe P. falciparum malaria), UM (uncomplicated P.
Nicholas Opoku (3542828), Frederica D. Partey (5352998), Sarah E. Silk (5353001), Margaret Kweku (259290), Michael F. Ofori (134417), Lea Barfod (134402), Gordon A. Awandare (247587), Edem W. Sarbah (5353004), Lars Hviid (75521), Simon J. Draper (124426), Filip C. Castberg (5353007)   +10 more
core   +1 more source

The effects of dyslipidaemia and cholesterol modulation on erythrocyte susceptibility to malaria parasite infection

Malaria Journal, 2019
Background Malaria disease commences when blood-stage parasites, called merozoites, invade human erythrocytes. Whilst the process of invasion is traditionally seen as being entirely merozoite-driven, emerging data suggests erythrocyte biophysical ...
Marion Koch, Jaimini Cegla, Ben Jones, Yuning Lu, Ziad Mallat, Andrew M. Blagborough, Fiona Angrisano, Jake Baum   +7 more
doaj   +1 more source

Profiling the antibody immune response against blood stage malaria vaccine candidates.

, 2007
BACKGROUND: The complexity and diversity of the antibody immune response to the antigen repertoire of a pathogen has long been appreciated. Although it has been recognized that the detection of antibodies against multiple antigens dramatically improves ...
Crisanti, Andrea, Mangia, Elena, Conway, David J, Riley, Eleanor M, Li, Qiuxiang, Holder, Anthony A, Corran, Patrick H, Tetteh, Kevin KA, Bacarese-Hamilton, Tito, Polley, Spencer D, Gaunt, Michael W, Gray, Julian C   +11 more
core   +1 more source

Strain variation of Babesia bovis merozoite surface-exposed epitopes

, 1991
Babesia bovis merozoites are exposed to antibodies during the extraerythrocytic phase, and surface polypeptides bearing exposed epitopes are possible immunogens.
Palmer, G H, Perryman, L E, Jasmer, D P, Reduker, D R, Shkap, V, Pipano, E, Goff, W L, McElwain, T F, McGuire, T C, Davis, W C   +9 more
core   +1 more source

PbPL is involved in merozoite release.

, 2015
HepG2 cells were infected with wild-type (WT), PbPL-knockout (KO2) and complemented PbPL-KO (CMP2) sporozoites. The percentage of attached hepatocytes containing schizont (S), cytomere (C) and merozoite (M) stage parasites was determined at 54 and 65 hpi.
Marco Schaffner (704678), Shahid M. Khan (190458), Volker T. Heussler (238787), Chris J. Janse (12383), Paul-Christian Burda (394976), Matthias A. Roelli (704677)   +5 more
core   +1 more source

Application of optical tweezer technology reveals that PfEBA and PfRH ligands, not PfMSP1, play a central role in Plasmodium falciparum merozoite-erythrocyte attachment.

PLoS Pathogens
Malaria pathogenesis and parasite multiplication depend on the ability of Plasmodium merozoites to invade human erythrocytes. Invasion is a complex multi-step process involving multiple parasite proteins which can differ between species and has been most
Emma Kals, Morten Kals, Rebecca A Lees, Viola Introini, Alison Kemp, Eleanor Silvester, Christine R Collins, Trishant Umrekar, Jurij Kotar, Pietro Cicuta, Julian C Rayner   +10 more
doaj   +1 more source

Basigin mediation of  Plasmodium falciparum red blood cell invasion does not require its transmembrane domain or interaction with monocarboxylate transporter 1.

PLoS Pathogens
Plasmodium falciparum invasion of the red blood cell is reliant upon the essential interaction of PfRh5 with the host receptor protein basigin. Basigin exists as part of one or more multiprotein complexes, most notably through interaction with the ...
Nadine R King, Catarina Martins Freire, Jawida Touhami, Marc Sitbon, Ashley M Toye, Timothy J Satchwell   +5 more
doaj   +1 more source

Proteome analysis reveals a large merozoite surface protein-1 associated complex on the Plasmodium falciparum merozoite surface

, 2010
Plasmodium merozoite surface protein-1 (MSP-1) is an essential antigen for the merozoite invasion of erythrocytes. A key challenge to the development of an effective malaria vaccine that can block the erythrocyte invasion is to establish the molecular ...
Korde, Reshma, Malhotra, Pawan, Asif Mohmmed, Kanodia, Shivani, Reddy, Vanga S., Dhawan, Shikha, Singh, Shivani, Vanga S. Reddy, Chauhan, Virander S., Grover, Amit, Ranjan, Ravi, Kumar, Saravanan, Virander S. Chauhan, Monika Chugh, Saravanan Kumar, Shikha Dhawan, Ravi Ranjan, Pawan Malhotra, Hossain, Manzar J., Reshma Korde, Amit Grover, Mohmmed, Asif, Shivani Kanodia, Shivani Singh, Chugh, Monika, Manzar J. Hossain   +25 more
core   +1 more source