Results 81 to 90 of about 33,075 (171)

Sequence diversity and evolutionary dynamics of the dimorphic antigen merozoite surface protein-6 and other Msp genes of Plasmodium falciparum.

, 2009
Immune evasion by Plasmodium falciparum is favored by extensive allelic diversity of surface antigens. Some of them, most notably the vaccine-candidate merozoite surface protein (MSP)-1, exhibit a poorly understood pattern of allelic dimorphism, in which
Roy, Scott W, Weedall, Gareth D, WEEDALL, Gareth D., SILVA, Rogerio L. da, POLLEY, Spencer D., Polley, Spencer D, ROY, Scott W., da Silva, Rogério L, Ferreira, Marcelo U, FERREIRA, Marcelo U.   +9 more
core   +1 more source

Hit‐To‐Lead Optimization of a Pyridylpiperazine Class Against Malaria: Pharmacokinetic Profile and In Vivo Efficacy of Optimized Compounds

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Chemical optimization of a novel pyridylpiperazine class yields two promising antimalarial candidates with an exceptional balance of metabolic stability and solubility. These optimized leads significantly protect mice from cerebral malaria, reducing parasitic load by up to 91.7%.
Douglas Davison da Silva Oliveira, Duarte Eduardo Pereira, Rafael Consolin Chelucci, Simone Michelan, Júlia Maria Fernandes Pituba, Adriano D. Andricopulo, Leonardo L. G. Ferreira, Neide Maria Silva, Celso de Oliveira Rezende Júnior   +8 more
wiley   +1 more source

Plug for the parasitophorous duct: a solution of two conundra

Malaria Journal, 2020
Background We present two conundra in the biology of intraerythrocytic malaria parasite: how an apparent open parasitophorous duct provide direct access of only a select set of serum proteins to the parasitophorous vacuole, and how proteases mediate ...
Prapon Wilairat, Saranya Auparakkitanon
doaj   +1 more source

Challenging the Clinical Paradigm of Hepatozoon canis: A Primary Pathogen Causing Clinically Significant Disease at Low Parasitaemia and a Chronic Inflammatory State

Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.
Hepatozoon canis causes significant clinical disease even at low parasitaemia and induces chronic subclinical anaemia and inflammation in dogs. Lack of tick control is the main modifiable risk factor. Molecular diagnosis is far more sensitive than microscopy, challenging the traditional view that disease severity depends solely on parasite burden ...
Somayeh Bahrami, Zahra Mashayekhi, Seyedeh Misagh Jalali, Mohammad Khosravi, Mohammad Rajabloo   +4 more
wiley   +1 more source

Protein Homeostasis and Mitochondrial Quality Control in Neurodegeneration

WIREs Mechanisms of Disease, Volume 18, Issue 4, July/August 2026.
Quality control pathways form an integrated proteostasis–mitochondrial quality control axis that maintains mitochondrial and cellular homeostasis. Failure of this coordinated network drives neuronal decline and contributes to neurodegeneration. ABSTRACT Quality control (QC) processes include a network of cellular pathways that prevent the accumulation ...
Rosa Di Lorenzo, Rola S. Zeidan, Riccardo Calvani, Vito Pesce, Emanuele Marzetti, Anna Picca   +5 more
wiley   +1 more source

Naturally acquired IgG responses to Plasmodium falciparum do not target the conserved termini of the malaria vaccine candidate Merozoite Surface Protein 2

Frontiers in Immunology
IntroductionMalaria remains a significant burden, and a fully protective vaccine against Plasmodium falciparum is critical for reducing morbidity and mortality.
Julia Zerebinski, Julia Zerebinski, Lucille Margerie, Lucille Margerie, Nan Sophia Han, Nan Sophia Han, Maximilian Moll, Matias Ritvos, Matias Ritvos, Peter Jahnmatz, Niklas Ahlborg, Billy Ngasala, Ingegerd Rooth, Ronald Sjöberg, Christopher Sundling, Christopher Sundling, Victor Yman, Victor Yman, Victor Yman, Anna Färnert, Anna Färnert, David Fernando Plaza, David Fernando Plaza   +22 more
doaj   +1 more source

Single‐Cell Transcriptomics and Development of Gametocyte‐Specific Molecular Markers for Avian Malaria Parasites

Molecular Ecology Resources, Volume 26, Issue 5, July 2026.
ABSTRACT Avian malaria, caused by Plasmodium parasites, poses a significant threat to bird populations worldwide, particularly in vulnerable island ecosystems. Yet, progress in understanding avian malaria transmission dynamics has been hampered by the lack of molecular tools to quantify and sex the transmissible stages of the parasite: the male and ...
A. Berthomieu, I. Rizos, J. W. Bagnoli, S. Gandon, A. M. Talman, A. Rivero   +5 more
wiley   +1 more source

The Babesia bovis merozoite surface antigen 1 hypervariable region induces surface-reactive antibodies that block merozoite invasion [PDF]

, 2006
A hypervariable region (HVR) previously identified in the carboxy-terminal one-third of the Babesia bovis variable merozoite surface antigen family was more extensively analyzed in merozoite surface antigen 1 (MSA-1) from 16 strains and isolates. The MSA-
Berens, Shawn J, Brown, Wendy C, LeRoith, Tanya, Norimine, Junzo, McElwain, Terry F, Hines, Stephen A, Brayton, Kelly A   +6 more
core   +1 more source

Lack of avidity maturation of merozoite antigen-specific antibodies with increasing exposure to Plasmodium falciparum amongst children and adults exposed to endemic malaria in Kenya.

PLoS ONE, 2012
BackgroundAlthough antibodies are critical for immunity to malaria, their functional attributes that determine protection remain unclear. We tested for associations between antibody avidities to Plasmodium falciparum (Pf) antigens and age, asymptomatic ...
Frances Ibison, Ally Olotu, Daniel M Muema, Jedida Mwacharo, Eric Ohuma, Domtila Kimani, Kevin Marsh, Philip Bejon, Francis M Ndungu   +8 more
doaj   +1 more source

Malaria: Endless Fascination with Merozoite Release [PDF]

, 2005
The erythrocytic asexual reproduction cycle of Plasmodium falciparum, the most lethal malaria parasite in humans, starts with the invasion of a red blood cell by a merozoite and ends with the release of up to 32 new copies of itself in about 48 hours.
Lew, Virgilio L.
core   +1 more source