Results 61 to 70 of about 28,776 (182)

Life Course Malaria Exposure and SARS‐CoV‐2 Seroepidemiology in Ugandan Adolescents: A Longitudinal Study Nested in a Birth Cohort

Tropical Medicine &International Health, Volume 31, Issue 8, Page 1012-1027, August 2026.
ABSTRACT Background COVID‐19 has had major global health impacts, yet reported morbidity and mortality have been lower in Africa despite serological evidence of widespread infection. Malaria has been proposed as a potential modifier of susceptibility to and outcomes of SARS‐CoV‐2 infection.
Ludoviko Zirimenya, Doreen Nayebare, Claire Baine, Jacent Nassuuna, Milly Namutebi, Christopher Zziwa, Denis Nsubuga, Fred Kiwudhu, Florence Akello, Josephine Tumusiime, Gloria Oduru, Grace Kabami, Hellen Akurut, Rachel Nakyesige, Agnes Natukunda, Anne Wajja, Lawrence Lubyayi, Simon Kimuda, Gyaviira Nkurunungi, Jennifer Serwanga, Katie J. Doores, Emily L. Webb, Alison M. Elliott   +22 more
wiley   +1 more source

Plug for the parasitophorous duct: a solution of two conundra

Malaria Journal, 2020
Background We present two conundra in the biology of intraerythrocytic malaria parasite: how an apparent open parasitophorous duct provide direct access of only a select set of serum proteins to the parasitophorous vacuole, and how proteases mediate ...
Prapon Wilairat, Saranya Auparakkitanon
doaj   +1 more source

Hit‐To‐Lead Optimization of a Pyridylpiperazine Class Against Malaria: Pharmacokinetic Profile and In Vivo Efficacy of Optimized Compounds

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Chemical optimization of a novel pyridylpiperazine class yields two promising antimalarial candidates with an exceptional balance of metabolic stability and solubility. These optimized leads significantly protect mice from cerebral malaria, reducing parasitic load by up to 91.7%.
Douglas Davison da Silva Oliveira, Duarte Eduardo Pereira, Rafael Consolin Chelucci, Simone Michelan, Júlia Maria Fernandes Pituba, Adriano D. Andricopulo, Leonardo L. G. Ferreira, Neide Maria Silva, Celso de Oliveira Rezende Júnior   +8 more
wiley   +1 more source

Challenging the Clinical Paradigm of Hepatozoon canis: A Primary Pathogen Causing Clinically Significant Disease at Low Parasitaemia and a Chronic Inflammatory State

Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.
Hepatozoon canis causes significant clinical disease even at low parasitaemia and induces chronic subclinical anaemia and inflammation in dogs. Lack of tick control is the main modifiable risk factor. Molecular diagnosis is far more sensitive than microscopy, challenging the traditional view that disease severity depends solely on parasite burden ...
Somayeh Bahrami, Zahra Mashayekhi, Seyedeh Misagh Jalali, Mohammad Khosravi, Mohammad Rajabloo   +4 more
wiley   +1 more source

Naturally acquired IgG responses to Plasmodium falciparum do not target the conserved termini of the malaria vaccine candidate Merozoite Surface Protein 2

Frontiers in Immunology
IntroductionMalaria remains a significant burden, and a fully protective vaccine against Plasmodium falciparum is critical for reducing morbidity and mortality.
Julia Zerebinski, Julia Zerebinski, Lucille Margerie, Lucille Margerie, Nan Sophia Han, Nan Sophia Han, Maximilian Moll, Matias Ritvos, Matias Ritvos, Peter Jahnmatz, Niklas Ahlborg, Billy Ngasala, Ingegerd Rooth, Ronald Sjöberg, Christopher Sundling, Christopher Sundling, Victor Yman, Victor Yman, Victor Yman, Anna Färnert, Anna Färnert, David Fernando Plaza, David Fernando Plaza   +22 more
doaj   +1 more source

Protein Homeostasis and Mitochondrial Quality Control in Neurodegeneration

WIREs Mechanisms of Disease, Volume 18, Issue 4, July/August 2026.
Quality control pathways form an integrated proteostasis–mitochondrial quality control axis that maintains mitochondrial and cellular homeostasis. Failure of this coordinated network drives neuronal decline and contributes to neurodegeneration. ABSTRACT Quality control (QC) processes include a network of cellular pathways that prevent the accumulation ...
Rosa Di Lorenzo, Rola S. Zeidan, Riccardo Calvani, Vito Pesce, Emanuele Marzetti, Anna Picca   +5 more
wiley   +1 more source

Lack of avidity maturation of merozoite antigen-specific antibodies with increasing exposure to Plasmodium falciparum amongst children and adults exposed to endemic malaria in Kenya.

PLoS ONE, 2012
BackgroundAlthough antibodies are critical for immunity to malaria, their functional attributes that determine protection remain unclear. We tested for associations between antibody avidities to Plasmodium falciparum (Pf) antigens and age, asymptomatic ...
Frances Ibison, Ally Olotu, Daniel M Muema, Jedida Mwacharo, Eric Ohuma, Domtila Kimani, Kevin Marsh, Philip Bejon, Francis M Ndungu   +8 more
doaj   +1 more source

Malaria: Endless Fascination with Merozoite Release [PDF]

Current Biology, 2005
The erythrocytic asexual reproduction cycle of Plasmodium falciparum, the most lethal malaria parasite in humans, starts with the invasion of a red blood cell by a merozoite and ends with the release of up to 32 new copies of itself in about 48 hours. A new study reveals that merozoite release is an explosive event ensuring the dispersal of these non ...
openaire   +2 more sources

A simple, ex vivo phagocytosis assay of Plasmodium vivax merozoites by flow cytometry

Memorias do Instituto Oswaldo Cruz
As phagocytosis is the first line of defense against malaria, we developed a phagocytosis assay with Plasmodium vivax (P. vivax) merozoites that can be applied to evaluate vaccine candidates. Briefly, after leukocyte removal with loosely packed cellulose
Elizangela Farias, Fhabiane Bezerra, Djane Clarys Baia-da-Silva, Yury Oliveira Chaves, Tatiana Bacry Cardoza, Maria Edilene Martins de Almeida, Lucas Barbosa Oliveira, Pritesh Lalwani, Patrícia Puccinelli Orlandi, Marcus Vinicius Guimaraes Lacerda, Stefanie Costa Pinto Lopes, Paulo Afonso Nogueira   +11 more
doaj   +1 more source

Ultrastructure of the Babesia divergens free merozoite

Ticks and Tick-borne Diseases, 2016
The invasive form of the apicomplexan parasite Babesia divergens, the free merozoite, invades the erythrocytes of host vertebrates, leading to significant pathology. Although invasion is an active process critical for parasite survival, it is not yet entirely understood.
María, Del Carmen Terrón, Fernando, González-Camacho, Luis Miguel, González, Daniel, Luque, Estrella, Montero   +4 more
openaire   +2 more sources