Results 51 to 60 of about 33,075 (171)

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

The FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath, Subhoja Chakraborty, Sampa Biswas   +2 more
wiley   +1 more source

Plasmodium chabaudi Merozoites Obtained through a Simpler Method Do Not Survive in Classically Activated Macrophages

Microorganisms
Malaria is caused by apicomplexan parasites of the Plasmodium genus. Plasmodium chabaudi is an excellent animal model for the study of human malaria caused by P. falciparum.
Pedro Souto Rodrigues, Milena de Farias Azeredo, Natália de Souza Almeida, Gisela Garcia Cabral Galaxe de Almeida, João Luiz Mendes Wanderley, Sergio Henrique Seabra, Renato Augusto DaMatta   +6 more
doaj   +1 more source

A novel merozoite surface antigen of Plasmodium falciparum (MSP-3) identified by cellular-antibody cooperative mechanism antigenicity and biological activity of antibodies

Memorias do Instituto Oswaldo Cruz, 1994
We report the identification of a 48kDa antigen targeted by antibodies which inhibit Plasmodium falciparum in vitro growth by cooperation with blood monocytes in an ADCI assay correlated to the naturally acquired protection.
Claude Oeuvray, Hasnaa Bouharoun-Tayoun, Heléne Grass-Masse, Jean Paul Iepers, Laurence Ralamboranto, André Tartar, Pierre Druilhe   +6 more
doaj   +1 more source

Antibodies targeting the PfRH1 binding domain inhibit invasion of Plasmodium falciparum merozoites. [PDF]

PLoS Pathogens, 2008
Invasion by the malaria merozoite depends on recognition of specific erythrocyte surface receptors by parasite ligands. Plasmodium falciparum uses multiple ligands, including at least two gene families, reticulocyte binding protein homologues (RBLs) and ...
Xiaohong Gao, Kim Pin Yeo, Siqi Sharon Aw, Claudia Kuss, Jayasree K Iyer, Saraswathy Genesan, Ravikumar Rajamanonmani, Julien Lescar, Zbynek Bozdech, Peter R Preiser   +9 more
doaj   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

A novel malaria vaccine candidate antigen expressed in Tetrahymena thermophila [PDF]

, 2014
Development of effective malaria vaccines is hampered by the problem of producing correctly folded Plasmodium proteins for use as vaccine components.
David R. Cavanagh, Hartmann Marcus W. W., Eleni-Muus Janna, Graeme J M Cowan, Ingo Aldag, Hartmann, Marcus W W, Samuel, Kay, Aldag Ingo, Samuel Kay, Alison M Creasey, Bockau, Ulrike, Cavanagh, David R, Alison M. Creasey, Creasey Alison M., Eleni-Muus, Janna, Cavanagh David R., Graeme J. M. Cowan, Cowan, Graeme J M; id_orcid, Ulrike Bockau, David R Cavanagh, Creasey, Alison M, Kay Samuel, Cowan Graeme J. M., Aldag, Ingo, Janna Eleni-Muus, Marcus W. W. Hartmann, Marcus W W Hartmann, Bockau Ulrike   +27 more
core   +2 more sources

Plasmodium falciparum Blood Stage Antimalarial Vaccines: An Analysis of Ongoing Clinical Trials and New Perspectives Related to Synthetic Vaccines

Frontiers in Microbiology, 2019
Plasmodium falciparum malaria is a disease causing high morbidity and mortality rates worldwide, mainly in sub-Saharan Africa. Candidates have been identified for vaccines targeting the parasite’s blood stage; this stage is important in the development ...
David Ricardo Salamanca, David Ricardo Salamanca, David Ricardo Salamanca, Marcela Gómez, Marcela Gómez, Marcela Gómez, Anny Camargo, Anny Camargo, Anny Camargo, Laura Cuy-Chaparro, Laura Cuy-Chaparro, Laura Cuy-Chaparro, Jessica Molina-Franky, Jessica Molina-Franky, Jessica Molina-Franky, César Reyes, César Reyes, Manuel Alfonso Patarroyo, Manuel Alfonso Patarroyo, Manuel Elkin Patarroyo, Manuel Elkin Patarroyo   +20 more
doaj   +1 more source

Characterization of Sec14 Domain–Containing Proteins in the Malaria Parasite Plasmodium falciparum

Molecular Microbiology, EarlyView.
During asexual blood‐stage development, P. falciparum Sec14 proteins display distinct localizations suggesting specialized roles in lipid exchange. PfSec14‐1 initially localizes to the nucleus before moving to the ER and Golgi alongside PfSec14‐4 during schizogony.
Florian Lauruol, Dominik Šťastný, J. Pedro Fernandez‐Murray, Christopher R. McMaster, Peter Griač, Dave Richard   +5 more
wiley   +1 more source

Differential patterns of human immunoglobulin G subclass responses to distinct regions of a single protein, the merozoite surface protein 1 of Plasmodium falciparum [PDF]

, 2001
Comparisons of immunoglobulin G (IgG) subclass responses to the major polymorphic region and to a conserved region of MSP-1 in three cohorts of African villagers exposed to Plasmodium falciparum revealed that responses to Block 2 are predominantly IgG3 ...
David R. Cavanagh, Cavanagh, D R, Cavanagh, DR, Ibrahim M. Elhassan, Elhassan, I M, Jana S. McBride, Theander, TG, Kevin Marsh, McBride, JS, Elhassan, A, Hviid, L, Khalil, E A T G, Ahmed Elhassan, Thor G. Theander, Cavanagh, David, Arnot, DE, Marsh, K, David E. Arnot, E. At Tahir G. Khalil, Khalil, EA, McBride, J S, Arnot, D E, Elhassan, IM, Theander, T G, Marsh, Kevin, Lars Hviid, Dobano, C, Carlota Dobaño, Khalil, E A   +28 more
core   +1 more source

A heparin-binding protein of Plasmodium berghei is associated with merozoite invasion of erythrocytes

Parasites & Vectors, 2023
Background Malaria caused by Plasmodium species is a prominent public health concern worldwide, and the infection of a malarial parasite is transmitted to humans through the saliva of female Anopheles mosquitoes.
Junying Gao, Ning Jiang, Yiwei Zhang, Ran Chen, Ying Feng, Xiaoyu Sang, Qijun Chen   +6 more
doaj   +1 more source