Results 41 to 50 of about 28,776 (182)

A novel merozoite surface antigen of Plasmodium falciparum (MSP-3) identified by cellular-antibody cooperative mechanism antigenicity and biological activity of antibodies

Memorias do Instituto Oswaldo Cruz, 1994
We report the identification of a 48kDa antigen targeted by antibodies which inhibit Plasmodium falciparum in vitro growth by cooperation with blood monocytes in an ADCI assay correlated to the naturally acquired protection.
Claude Oeuvray, Hasnaa Bouharoun-Tayoun, Heléne Grass-Masse, Jean Paul Iepers, Laurence Ralamboranto, André Tartar, Pierre Druilhe   +6 more
doaj   +1 more source

Antibodies targeting the PfRH1 binding domain inhibit invasion of Plasmodium falciparum merozoites. [PDF]

PLoS Pathogens, 2008
Invasion by the malaria merozoite depends on recognition of specific erythrocyte surface receptors by parasite ligands. Plasmodium falciparum uses multiple ligands, including at least two gene families, reticulocyte binding protein homologues (RBLs) and ...
Xiaohong Gao, Kim Pin Yeo, Siqi Sharon Aw, Claudia Kuss, Jayasree K Iyer, Saraswathy Genesan, Ravikumar Rajamanonmani, Julien Lescar, Zbynek Bozdech, Peter R Preiser   +9 more
doaj   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, Volume 46, Issue 6, Page 1477-1498, November 2026.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Plasmodium falciparum Blood Stage Antimalarial Vaccines: An Analysis of Ongoing Clinical Trials and New Perspectives Related to Synthetic Vaccines

Frontiers in Microbiology, 2019
Plasmodium falciparum malaria is a disease causing high morbidity and mortality rates worldwide, mainly in sub-Saharan Africa. Candidates have been identified for vaccines targeting the parasite’s blood stage; this stage is important in the development ...
David Ricardo Salamanca, David Ricardo Salamanca, David Ricardo Salamanca, Marcela Gómez, Marcela Gómez, Marcela Gómez, Anny Camargo, Anny Camargo, Anny Camargo, Laura Cuy-Chaparro, Laura Cuy-Chaparro, Laura Cuy-Chaparro, Jessica Molina-Franky, Jessica Molina-Franky, Jessica Molina-Franky, César Reyes, César Reyes, Manuel Alfonso Patarroyo, Manuel Alfonso Patarroyo, Manuel Elkin Patarroyo, Manuel Elkin Patarroyo   +20 more
doaj   +1 more source

A heparin-binding protein of Plasmodium berghei is associated with merozoite invasion of erythrocytes

Parasites & Vectors, 2023
Background Malaria caused by Plasmodium species is a prominent public health concern worldwide, and the infection of a malarial parasite is transmitted to humans through the saliva of female Anopheles mosquitoes.
Junying Gao, Ning Jiang, Yiwei Zhang, Ran Chen, Ying Feng, Xiaoyu Sang, Qijun Chen   +6 more
doaj   +1 more source

Autoantibodies to Extracellular Erythrocyte Band 3 Epitopes Are Associated With Anemia in Plasmodium vivax Infection

American Journal of Hematology, Volume 101, Issue 10, Page 2592-2604, October 2026.
ABSTRACT Plasmodium vivax‐associated anemia is a multifactorial clinical outcome, in which the destruction of uninfected red blood cells (uRBCs) plays a major role in disease development and severity. Here, we identified autoantibody targets within the extracellular loops of Band 3 (B3), a major erythrocyte transmembrane protein.
Aline Marzano‐Miranda, Vanessa G. Fraga, Cor Jésus F. Fontes, Simone Ladeia‐Andrade, Marcelo U. Ferreira, Daniella C. Bartholomeu, Érika M. Braga   +6 more
wiley   +1 more source

Relationship between malaria incidence and IgG levels to Plasmodium falciparum merozoite antigens in Malian children: impact of hemoglobins S and C. [PDF]

PLoS ONE, 2013
Heterozygous hemoglobin (Hb) AS (sickle-cell trait) and HbAC are hypothesized to protect against Plasmodium falciparum malaria in part by enhancing naturally-acquired immunity to this disease.
Kazutoyo Miura, Mahamadou Diakite, Ababacar Diouf, Saibou Doumbia, Drissa Konate, Abdoul S Keita, Samuel E Moretz, Gregory Tullo, Hong Zhou, Tatiana M Lopera-Mesa, Jennifer M Anderson, Rick M Fairhurst, Carole A Long   +12 more
doaj   +1 more source

Characterization of Sec14 Domain–Containing Proteins in the Malaria Parasite Plasmodium falciparum

Molecular Microbiology, Volume 126, Issue 4, Page 412-432, October 2026.
During asexual blood‐stage development, P. falciparum Sec14 proteins display distinct localizations suggesting specialized roles in lipid exchange. PfSec14‐1 initially localizes to the nucleus before moving to the ER and Golgi alongside PfSec14‐4 during schizogony.
Florian Lauruol, Dominik Šťastný, J. Pedro Fernandez‐Murray, Christopher R. McMaster, Peter Griač, Dave Richard   +5 more
wiley   +1 more source

Peptide‐Enabled Nanoplatforms for Malaria and Leishmaniasis: From Intracellular Targeting to Translational Diagnostic Perspectives

ChemMedChem, Volume 21, Issue 18, 28 September 2026.
Peptide‐enabled nanoplatforms offer multifunctional strategies for the treatment and diagnosis of malaria and leishmaniasis. Liposomal, polymeric, and metallic nanocarriers, together with cell‐penetrating peptides and parasite‐derived mimotopes, can improve targeted drug delivery, stability, bioavailability, and intracellular localization.
Christian S. Carnero Canales, Ana Clara Lunardi Yagi, Túlio Custódio Reis, Jessica Ingrid Cazorla, Jade Rojas Villar, Marcia A. Graminha, Roxana Yesenia Pastrana Alta, Fernando Rogério Pavan   +7 more
wiley   +1 more source

Clinical Case and Follow‐Up of Babesia banethi Infection in a Red Fox

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
A naturally occurring Babesia banethi infection in a sick red fox was followed up for more than one year through cytology, haematobiochemical profiles and molecular analyses. Imidocarb treatment resulted in temporary clinical improvement and later relapse, whereas atovaquone/proguanil combined with azithromycin led to clinical recovery and parasite ...
Mariaelisa Carbonara, Michela Prioletti, Antonio Camarda, Stefano Castellana, Giuseppe Menga, Giovanna Girardi, Gad Baneth, Domenico Otranto   +7 more
wiley   +1 more source