Results 41 to 50 of about 33,075 (171)

Naturally acquired antibodies from Beninese infants promote Plasmodium falciparum merozoite-phagocytosis by human blood leukocytes: implications for control of asymptomatic malaria infections

Malaria Journal, 2022
Background Immunoglobulin G (IgG) antibodies are thought to play important roles in the protection against Plasmodium falciparum (P. falciparum) malaria.
Abdou Khadre Dit Jadir Fall, Ikhlaq Hussain Kana, Célia Dechavanne, Asier Garcia-Senosiain, Evelyne Guitard, Jacqueline Milet, Achille Massougbodji, André Garcia, Jean-Michel Dugoujon, Florence Migot-Nabias, Michael Theisen, David Courtin   +11 more
doaj   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Acquisition of antibody isotypes against Plasmodium falciparum blood stage antigens in a birth cohort. [PDF]

, 2010
Information on the period during which infants lose their maternally derived antibodies to malaria and begin to acquire naturally their own immune responses against parasite antigens is crucial for understanding when malaria vaccines may be best ...
Duah, NO, D. J. C. MILES, Conway, DJ, N. O. DUAH, Whittle, HC, H. C. WHITTLE, D. J. CONWAY, Miles, DJC   +7 more
core   +1 more source

Contrasting population structures of the genes encoding ten leading vaccine-candidate antigens of the human malaria parasite, Plasmodium falciparum. [PDF]

PLoS ONE, 2009
The extensive diversity of Plasmodium falciparum antigens is a major obstacle to a broadly effective malaria vaccine but population genetics has rarely been used to guide vaccine design.
Alyssa E Barry, Lee Schultz, Caroline O Buckee, John C Reeder   +3 more
doaj   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Cohort study of the association of antibody levels to AMA1, MSP119, MSP3 and GLURP with protection from clinical malaria in Ghanaian children. [PDF]

, 2008
BACKGROUND: Antigen-specific antibody-mediated immune responses play an important role in natural protection against clinical malaria, but conflicting estimates of this association have emerged from immuno-epidemiological studies in different ...
Remarque Ed, Aikins, Anastasia, Chilengi Roma, Roma Chilengi, Kwadwo Asamoah Kusi, Aikins Anastasia, Yaa Difie Osei, Dodoo, Daniel, Lamptey, Helena, Ed Remarque, Paul Milligan, Akanmori, Bartholomew Dicky, Samuel Bosomprah, Osei Yaa Difie, Chilengi, Roma, Milligan Paul, Kusi Kwadwo, Bosomprah Samuel, Theisen, Michael, Daniel Dodoo, Milligan, Paul, Kusi, Kwadwo Asamoah, Anastasia Aikins, Remarque, Ed, Helena Lamptey, Akanmori Bartholomew, Theisen Michael, Lamptey Helena, Dodoo Daniel, Bosomprah, Samuel, Osei, Yaa Difie, Michael Theisen, Bartholomew Dicky Akanmori   +32 more
core   +1 more source

Expression of the MSPDBL2 antigen in a discrete subset of Plasmodium falciparum schizonts is regulated by GDV1 but may not be linked to sexual commitment

mBio
The Plasmodium falciparum merozoite surface protein MSPDBL2 is a polymorphic antigen targeted by acquired immune responses, and normally expressed in only a minority of mature schizonts.
Aline Freville, Lindsay B. Stewart, Kevin K. A. Tetteh, Moritz Treeck, Alfred Cortes, Till S. Voss, Sarah J. Tarr, David A. Baker, David J. Conway   +8 more
doaj   +1 more source

Aspects of immunity for the AMA-1 family of molecules in humans and non-human primates malarias

Memorias do Instituto Oswaldo Cruz, 1994
The apical membrane antigen (AMA-1) family of malaria merozoite proteins is characterised by a high degree of inter-species conservation. Evidence that the protein (PK66/AMA-1) from the simian parasite Plasmodium knowlesi was protective in rhesus monkeys
A. W. Thomas, D. Narum, A. P. Waters, J. F. Trape, C. Rogier, A. Gonçalves, V. Rosario, P. Druilhe, G. H. Mitchell, D. Dennis   +9 more
doaj   +1 more source

Parasites at the Summit: Unexpected Geographic Distribution of the Blood Parasite Lineage Found in the Endangered Giant Lizard of Tenerife

Integrative Zoology, EarlyView.
We combined microscopic screening and molecular phylogenetic analyses to characterize blood parasites infecting Gallotia intermedia from the coastal cliffs of Montaña de Guaza and to place these infections in a broader biogeographic context. We detected apicomplexan parasites of the genus Karyolysus infecting 53.6% of G.
Rodrigo Megía‐Palma, Gonzalo Albaladejo‐Robles, Gemma Palomar, Javier Martínez, Anamarija Žagar, Alejandro Escánez‐Pérez, Miguel A. Carretero, Wiesław Babik, Santiago Merino   +8 more
wiley   +1 more source

Humoral and cell-mediated immunity to MSP3 peptides in adults immunized with MSP3 in malaria endemic area, Burkina Faso. [PDF]

, 2009
We performed a single-blind, randomized phase 1 trial of the long synthetic peptide (LSP) of merozoite surface protein-3 (MSP3) in adults living in Burkina Faso.
A. B. TIONO, O. LEROY, Sirima, SB, Cousens, S, A. GANSANE, Diarra, A, Gansane, A, Soulama, I, Nebie, I, Konate, AT, A. OUEDRAOGO, I. SOULAMA, A. DIARRA, Leroy, O, I. NEBIE, A. T. KONATE, Tiono, AB, Ouedraogo, A, S. COUSENS, S. B. SIRIMA   +19 more
core   +1 more source