IgG antibody responses to Plasmodium falciparum merozoite antigens in Kenyan children have a short half-life. [PDF]
, 2007 BACKGROUND: Data suggest that antibody responses to malaria parasites merozoite antigens are generally short-lived and this has implications for serological studies and malaria vaccine designs.
Conway, David J +15 more
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Boosting antibody responses to Plasmodium falciparum merozoite antigens in children with highly seasonal exposure to infection. [PDF]
, 2010 Longitudinal cohort studies are important to describe the dynamics of naturally acquired antibody response profiles to defined Plasmodium falciparum malaria antigens relative to clinical malaria episodes.
M. PINDER +7 more
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Differences in affinity of monoclonal and naturally acquired polyclonal antibodies against Plasmodium falciparum merozoite antigens [PDF]
, 2015 Malaria is a major global cause of deaths and a vaccine is urgently needed.; We have employed the P. falciparum merozoite antigens MSP2-3D7/FC27 and AMA1, used them in ELISA, and coupled them in different ways using surface plasmon resonance (SPR) and ...
Stanisic, Danielle +41 more
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Antibodies to the N-terminal block 2 of Plasmodium falciparum merozoite surface protein 1 are associated with protection against clinical malaria. [PDF]
, 2004 This longitudinal prospective study shows that antibodies to the N-terminal block 2 region of the Plasmodium falciparum merozoite surface protein 1 (MSP-1) are associated with protection against clinical malaria in an area of stable but seasonal malaria ...
Conway, David J +31 more
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Functional Comparison of Blood-Stage Plasmodium falciparum Malaria Vaccine Candidate Antigens
Frontiers in Immunology, 2019 The malaria genome encodes over 5,000 proteins and many of these have also been proposed to be potential vaccine candidates, although few of these have been tested clinically.
Joseph J. Illingworth +17 more
doaj +1 more source
Breadth and magnitude of antibody responses to multiple Plasmodium falciparum merozoite antigens are associated with protection from clinical malaria. [PDF]
, 2008 Individuals living in areas where malaria is endemic are repeatedly exposed to many different malaria parasite antigens. Studies on naturally acquired antibody-mediated immunity to clinical malaria have largely focused on the presence of responses to ...
Mackinnon, Margaret J +60 more
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Frontiers in Immunology, 2018 Passive transfer studies in humans clearly demonstrated the protective role of IgG antibodies against malaria. Identifying the precise parasite antigens that mediate immunity is essential for vaccine design, but has proved difficult.
Gathoni Kamuyu +38 more
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Functional and immunological analysis of the different domains of "Plasmodium falciparum" merozoite surface protein 2 (MSP2) [PDF]
, 2005 Malaria caused by Plasmodium falciparum is still a major health problem in many tropical countries infecting 500 million people leading to 1 to 2 millions of deaths annually.
Flück, Christian
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Naturally Acquired Humoral Immunity Against Plasmodium falciparum Malaria
Frontiers in Immunology, 2020 Malaria remains a significant contributor to the global burden of disease, with around 40% of the world’s population at risk of Plasmodium infections. The development of an effective vaccine against the malaria parasite would mark a breakthrough in the ...
S. Jake Gonzales +5 more
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Plasmodium falciparum merozoite surface protein 2: epitope mapping and fine specificity of human antibody response against non-polymorphic domains [PDF]
, 2014 Two long synthetic peptides representing the dimorphic and constant C-terminal domains of the two allelic families of Plasmodium falciparum merozoite surface proteins 2 are considered promising malaria vaccine candidates.
Kajava, Andrey V. +15 more
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