Results 21 to 30 of about 28,776 (182)
Frontiers in Immunology, 2018 Passive transfer studies in humans clearly demonstrated the protective role of IgG antibodies against malaria. Identifying the precise parasite antigens that mediate immunity is essential for vaccine design, but has proved difficult.
Gathoni Kamuyu +38 more
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Naturally Acquired Humoral Immunity Against Plasmodium falciparum Malaria
Frontiers in Immunology, 2020 Malaria remains a significant contributor to the global burden of disease, with around 40% of the world’s population at risk of Plasmodium infections. The development of an effective vaccine against the malaria parasite would mark a breakthrough in the ...
S. Jake Gonzales +5 more
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Expression and Localization Profiles of Rhoptry Proteins in Plasmodium berghei Sporozoites
Frontiers in Cellular and Infection Microbiology, 2019 In the Plasmodium lifecycle two infectious stages of parasites, merozoites, and sporozoites, efficiently infect mammalian host cells, erythrocytes, and hepatocytes, respectively.
Naohito Tokunaga +7 more
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Nature Communications, 2023 Plasmodium falciparum causes the most severe form of malaria in humans. The protozoan parasite develops within erythrocytes to mature schizonts, that contain more than 16 merozoites, which egress and invade fresh erythrocytes.
Tony Triglia +5 more
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Merozoite Proteins Discovered by qRT-PCR-Based Transcriptome Screening of Plasmodium falciparum
Frontiers in Cellular and Infection Microbiology, 2021 The development of malaria vaccines and medicines depends on the discovery of novel malaria protein targets, but the functions of more than 40% of P. falciparum genes remain unknown. Asexual parasites are the critical stage that leads to serious clinical
Nan Hou +8 more
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The malaria merozoite, forty years on
Parasitology, 2009 SUMMARYThe invasive blood stage of malaria parasites, merozoites, are complex entities specialized for the capture and entry of red blood cells. Their potential for vaccination and other anti-malaria strategies have attracted much research attention over the last 40 years, and there is now a considerable body of data relating to their biology.
Bannister, L. H., Mitchell, G. H.
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Plasmodium falciparum GAP40 Plays an Essential Role in Merozoite Invasion and Gametocytogenesis
Microbiology Spectrum, 2023 Cyclic invasion of red blood cells (RBCs) by Plasmodium merozoites is associated with the symptoms and pathology of malaria. Merozoite invasion is powered actively and rapidly by a parasite actomyosin motor called the glideosome.
Lu He +11 more
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SURGE complex of Plasmodium falciparum in the rhoptry-neck (SURFIN4.2-RON4-GLURP) contributes to merozoite invasion. [PDF]
PLoS ONE, 2018 Plasmodium falciparum invasion into red blood cells (RBCs) is a complex process engaging proteins on the merozoite surface and those contained and sequentially released from the apical organelles (micronemes and rhoptries). Fundamental to invasion is the
Maria Del Pilar Quintana +10 more
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Temporal gene expression during asexual development of the apicomplexan Sarcocystis neurona
mSphereAsexual replication in the apicomplexan Sarcocystis neurona involves two main developmental stages: the motile extracellular merozoite and the sessile intracellular schizont.
Sriveny Dangoudoubiyam +8 more
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Efficient measurement of opsonising antibodies to Plasmodium falciparum merozoites. [PDF]
PLoS ONE, 2012 Antibodies targeting merozoites are important in protection from malaria. Therefore, merozoite surface proteins are attractive vaccine candidates. There is a need for robust functional assays to investigate mechanisms of acquired immunity and vaccine ...
Danika L Hill +6 more
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