Results 11 to 20 of about 28,776 (182)
Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future [PDF]
Medicinal Research Reviews, Volume 46, Issue 6, Page 1574-1602, November 2026.ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley +2 more sources
An abundant merozoite surface protein of Plasmodium falciparum modulates susceptibility to inhibitory antibodies [PDF]
eLifeMalaria merozoite surface proteins (MSPs) are thought to have important roles in red blood cell (RBC) invasion and their exposure on the parasite surface makes them attractive vaccine candidates.
Isabelle G Henshall +10 more
doaj +2 more sources
Physiology of invasive Plasmodium merozoites [PDF]
Frontiers in Cellular and Infection MicrobiologyMalaria, a life-threatening disease caused by Plasmodium parasites, relies on a specialized stage, the merozoite to invade red blood cells and multiply in the bloodstream.
Mansoor A Siddiqui
doaj +2 more sources
Proliferating toward sex: characterization of cell division of Toxoplasma gondii’s pre-sexual stages [PDF]
mBioToxoplasmosis is a disease of worldwide distribution, causing high morbidity and mortality in humans, as well as heavily impacting animal health and the economy.
Florencia Sena +2 more
doaj +2 more sources
The Plasmodium berghei merozoite protein PbGAC is critically involved in erythrocyte binding during invasion [PDF]
Parasites & VectorsBackground The invasion of Plasmodium merozoites into host erythrocytes is initiated through specific ligand–receptor interactions. This interaction results in subsequent invasion events, facilitated by the formation of a moving junction via AMA-1 and ...
Junying Gao +6 more
doaj +2 more sources
Gliding motility of Plasmodium merozoites [PDF]
Proceedings of the National Academy of Sciences, 2020 Significance Plasmodium malaria parasites use a unique substrate-dependent locomotion, termed gliding motility, to migrate through tissues and invade cells. Previously, it was thought that the small labile invasive stages that invade erythrocytes, merozoites, use this motility solely to ...
Kazuhide Yahata +8 more
openaire +3 more sources
Frontiers in Microbiology, 2021 We review the role of signaling pathways in regulation of the key processes of merozoite egress and red blood cell invasion by Plasmodium falciparum and, in particular, the importance of the second messengers, cAMP and Ca2+, and cyclic nucleotide ...
Edwin Lasonder +11 more
doaj +1 more source
eLife, 2017 The most lethal form of malaria in humans is caused by Plasmodium falciparum. These parasites invade erythrocytes, a complex process involving multiple ligand-receptor interactions.
Xavier Sisquella +12 more
doaj +1 more source
Comparisons of the Sexual Cycles for the Coccidian Parasites Eimeria and Toxoplasma
Frontiers in Cellular and Infection Microbiology, 2020 Toxoplasma gondii and Eimeria spp. are widely prevalent Coccidian parasites that undergo sexual reproduction during their life cycle. T. gondii can infect any warm-blooded animal in its asexual cycle; however, its sexual cycle is restricted to felines ...
Bruno Martorelli Di Genova +1 more
doaj +1 more source
Functional Comparison of Blood-Stage Plasmodium falciparum Malaria Vaccine Candidate Antigens
Frontiers in Immunology, 2019 The malaria genome encodes over 5,000 proteins and many of these have also been proposed to be potential vaccine candidates, although few of these have been tested clinically.
Joseph J. Illingworth +17 more
doaj +1 more source